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Autor
Adli, Mazda 1 Akiyama, Kazufumi 1 Akula, Nirmala 1 Alda, Martin 1 Amare, Azmeraw T 1 Ardau, Raffaella 1 Arias, Bárbara 1 Aubry, Jean-Michel 1 Backlund, Lena 1 Barrau, Caroline 1 Bauer, Michael 1 Baune, Bernhard T 1 Bellivier, Frank 1 Benabarre, Antonio 1 Bengesser, Susanne 1 Bhattacharjee, Abesh Kumar 1 Biernacka, Joanna M 1 Birner, Armin 1 Boukouaci, Wahid 1 Brichant-Petitjean, Clara 1
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Pracoviště
AP HP Hôpital Henri Mondor Départemen... 1 Biometric Psychiatric Genetics Resear... 1 Bipolar Center Wiener Neustadt Medica... 1 Bipolar Disorder Program Institute of... 1 Center for Molecular Medicine Karolin... 1 Centre Investigation Clinique CIC Hen... 1 Centre for Human Genetics University ... 1 Centro de Investigación Biomédica en ... 1 Centro de Investigación Biomédica en ... 1 Departament de Genètica Microbiologia... 1 Department of Adult Psychiatry Poznan... 1 Department of Biological Psychiatry a... 1 Department of Biomedical Sciences Uni... 1 Department of Clinical Neurosciences ... 1 Department of Genetic Epidemiology in... 1 Department of Health Sciences Researc... 1 Department of Medical Epidemiology an... 1 Department of Mental Health Johns Hop... 1 Department of Molecular Medicine and ... 1 Department of Neurobiology Care Scien... 1
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Autor
Adli, Mazda 1 Akiyama, Kazufumi 1 Akula, Nirmala 1 Alda, Martin 1 Amare, Azmeraw T 1 Ardau, Raffaella 1 Arias, Bárbara 1 Aubry, Jean-Michel 1 Backlund, Lena 1 Barrau, Caroline 1 Bauer, Michael 1 Baune, Bernhard T 1 Bellivier, Frank 1 Benabarre, Antonio 1 Bengesser, Susanne 1 Bhattacharjee, Abesh Kumar 1 Biernacka, Joanna M 1 Birner, Armin 1 Boukouaci, Wahid 1 Brichant-Petitjean, Clara 1
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Pracoviště
AP HP Hôpital Henri Mondor Départemen... 1 Biometric Psychiatric Genetics Resear... 1 Bipolar Center Wiener Neustadt Medica... 1 Bipolar Disorder Program Institute of... 1 Center for Molecular Medicine Karolin... 1 Centre Investigation Clinique CIC Hen... 1 Centre for Human Genetics University ... 1 Centro de Investigación Biomédica en ... 1 Centro de Investigación Biomédica en ... 1 Departament de Genètica Microbiologia... 1 Department of Adult Psychiatry Poznan... 1 Department of Biological Psychiatry a... 1 Department of Biomedical Sciences Uni... 1 Department of Clinical Neurosciences ... 1 Department of Genetic Epidemiology in... 1 Department of Health Sciences Researc... 1 Department of Medical Epidemiology an... 1 Department of Mental Health Johns Hop... 1 Department of Molecular Medicine and ... 1 Department of Neurobiology Care Scien... 1
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- Le Clerc, Sigrid
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Lombardi, Laura
Autor Lombardi, Laura AP-HP, Hôpital Henri Mondor, Département Médico-Universitaire de Psychiatrie et D'Addictologie (DMU IMPACT), Fédération Hospitalo-Universitaire de Médecine de Précision (FHU ADAPT), 94010, Créteil, France INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie Translationnelle, Université Paris Est Créteil, 94010, Créteil, France Fondation FondaMental, Créteil, France
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Baune, Bernhard T
Autor Baune, Bernhard T Department of Psychiatry, University of Münster, Münster, Germany Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Australia The Florey Institute of Neuroscience and Mental Health, The University of Melbourne Parkville, Parkville, VIC, Australia
- Amare, Azmeraw T
- Schubert, Klaus Oliver
- Hou, Liping
- Clark, Scott R
- Papiol, Sergi
- Cearns, Micah
- Heilbronner, Urs
Free Medical Journals od 2011
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PubMed Central od 2011
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ROAD: Directory of Open Access Scholarly Resources od 2011
PubMed
34497278
DOI
10.1038/s41598-021-97140-7
Knihovny.cz E-zdroje
Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. We found our best signal for amino-acid variants belonging to the HLA-DRB1*11:01 classical allele, associated with a better response to Li (p < 1 × 10-3; FDR < 0.09 in the recessive model). Alanine or Leucine at position 74 of the HLA-DRB1 heavy chain was associated with a good response while Arginine or Glutamic acid with a poor response. As these variants have been implicated in common inflammatory/autoimmune processes, our findings strongly suggest that HLA-mediated low inflammatory background may contribute to the efficient response to Li in BD patients, while an inflammatory status overriding Li anti-inflammatory properties would favor a weak response.
- MeSH
- alely MeSH
- bipolární porucha farmakoterapie genetika MeSH
- dospělí MeSH
- farmakogenetika MeSH
- frekvence genu MeSH
- genetická predispozice k nemoci * MeSH
- genetická variace MeSH
- genotyp MeSH
- haplotypy MeSH
- HLA-DQ beta řetězec genetika MeSH
- HLA-DRB1 řetězec genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- lithium terapeutické užití MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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