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Autor
Bürkner, Paul-Christian 1 Casas-Mendez, Luis Fernando 1 Christozova, Kristína 1 Fišer, Karel 1 Horejsek, Jan 1 Hrušák, Kristián 1 Hyánek, Tomáš 1 Jaroš, Adam 1 Jedlička, Martin 1 Kubiska, Miroslav 1 Kubricht, Viktor 1 Leos-Barajas, Vianey 1 Mesežnikov, Grigorij 1 Mifková, Adriana 1 Modrák, Martin 1 Pokrievková, Rebeka 1 Pospíšil, Zbyšek 1 Sieger, Tomáš 1 Slisz, Tomáš 1 Suk, Daniel 1
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Pracoviště
2nd Faculty of Medicine Charles Unive... 1 3rd Faculty of Medicine Charles Unive... 1 AGEL Hospital Nový Jičín Nový Jičín C... 1 Bioinformatics Core Facility Institut... 1 Cluster of Excellence SimTech Univers... 1 Department of Bioinformatics 2nd Facu... 1 Department of Infectious Diseases and... 1 Department of Respiratory Medicine 1s... 1 Department of Statistical Sciences Un... 1 Dept of Cybernetics Faculty of Electr... 1 General University Hospital Prague Pr... 1 Hořovice Hospital Hořovice Czech Repu... 1 Kralovské Vinohrady University Hospit... 1 Military Hospital Olomouc Olomouc Cze... 1 Motol University Hospital Prague Czec... 1 Na Homolce Hospital Prague Czech Repu... 1 Thomayer University Hospital Prague C... 1 Třebíč Hospital Třebíč Czech Republic 1
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Autor
Bürkner, Paul-Christian 1 Casas-Mendez, Luis Fernando 1 Christozova, Kristína 1 Fišer, Karel 1 Horejsek, Jan 1 Hrušák, Kristián 1 Hyánek, Tomáš 1 Jaroš, Adam 1 Jedlička, Martin 1 Kubiska, Miroslav 1 Kubricht, Viktor 1 Leos-Barajas, Vianey 1 Mesežnikov, Grigorij 1 Mifková, Adriana 1 Modrák, Martin 1 Pokrievková, Rebeka 1 Pospíšil, Zbyšek 1 Sieger, Tomáš 1 Slisz, Tomáš 1 Suk, Daniel 1
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Pracoviště
2nd Faculty of Medicine Charles Unive... 1 3rd Faculty of Medicine Charles Unive... 1 AGEL Hospital Nový Jičín Nový Jičín C... 1 Bioinformatics Core Facility Institut... 1 Cluster of Excellence SimTech Univers... 1 Department of Bioinformatics 2nd Facu... 1 Department of Infectious Diseases and... 1 Department of Respiratory Medicine 1s... 1 Department of Statistical Sciences Un... 1 Dept of Cybernetics Faculty of Electr... 1 General University Hospital Prague Pr... 1 Hořovice Hospital Hořovice Czech Repu... 1 Kralovské Vinohrady University Hospit... 1 Military Hospital Olomouc Olomouc Cze... 1 Motol University Hospital Prague Czec... 1 Na Homolce Hospital Prague Czech Repu... 1 Thomayer University Hospital Prague C... 1 Třebíč Hospital Třebíč Czech Republic 1
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Free Medical Journals od 2006
Public Library of Science (PLoS) od 2006
PubMed Central od 2006
Europe PubMed Central od 2006
ProQuest Central od 2006-12-01
Open Access Digital Library od 2006-10-01
Open Access Digital Library od 2006-01-01
Open Access Digital Library od 2006-01-01
Medline Complete (EBSCOhost) od 2008-01-01
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ROAD: Directory of Open Access Scholarly Resources od 2006
PubMed
34613965
DOI
10.1371/journal.pone.0245103
Knihovny.cz E-zdroje
We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested positive for SARS-CoV-2 during the early phases of the pandemic in March-October 2020. The dataset contains baseline patient characteristics, breathing support required, pharmacological treatment received and multiple markers on daily resolution. Patients in the dataset were treated with hydroxychloroquine (N = 108), azithromycin (N = 72), favipiravir (N = 9), convalescent plasma (N = 7), dexamethasone (N = 4) and remdesivir (N = 3), often in combination. To explore association between treatments and patient outcomes we performed multiverse analysis, observing how the conclusions change between defensible choices of statistical model, predictors included in the model and other analytical degrees of freedom. Weak evidence to constrain the potential efficacy of azithromycin and favipiravir can be extracted from the data. Additionally, we performed external validation of several proposed prognostic models for Covid-19 severity showing that they mostly perform unsatisfactorily on our dataset.
- MeSH
- COVID-19 farmakoterapie epidemiologie patologie terapie MeSH
- dospělí MeSH
- hospitalizace * MeSH
- lidé středního věku MeSH
- lidé MeSH
- progrese nemoci * MeSH
- senioři MeSH
- statistické modely MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
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