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Autor
Agostinis, Patrizia 1 Apetoh, Lionel 1 Baert, Thais 1 Birge, Raymond B 1 Bravo-San Pedro, José Manuel 1 Breckpot, Karine 1 Brough, David 1 Chaurio, Ricardo 1 Cirone, Mara 1 Coosemans, An 1 Coulie, Pierre G 1 De Ruysscher, Dirk 1 Dini, Luciana 1 Dudek-Peric, Aleksandra M 1 Faggioni, Alberto 1 Fucikova, Jitka 1 Gaipl, Udo S 1 Galluzzi, Lorenzo 1 Garg, Abhishek D 1 Golab, Jakub 1
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Pracoviště
BioTechMed Graz Graz Austria 1 Biotherapy and Vaccine Unit Institut ... 1 Cancer Gene Therapy Group Transplanta... 1 Cell Death Research and Therapy Labor... 1 Center of Clinical Investigations in ... 1 Centre Georges François Leclerc Dijon... 1 Centre de Recherche du Centre Hospita... 1 Department of Biological and Environm... 1 Department of Biomedical Molecular Bi... 1 Department of Ecological and Biologic... 1 Department of Experimental Medicine S... 1 Department of Gynaecology and Obstetr... 1 Department of Immunology 2nd Faculty ... 1 Department of Immunology Medical Univ... 1 Department of Internal Medicine 3 Rhe... 1 Department of Medical Oncology Univer... 1 Department of Microbiology Biochemist... 1 Department of Oncology University of ... 1 Department of Paediatric Haematology ... 1 Department of Radiation Oncology Klin... 1
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Autor
Agostinis, Patrizia 1 Apetoh, Lionel 1 Baert, Thais 1 Birge, Raymond B 1 Bravo-San Pedro, José Manuel 1 Breckpot, Karine 1 Brough, David 1 Chaurio, Ricardo 1 Cirone, Mara 1 Coosemans, An 1 Coulie, Pierre G 1 De Ruysscher, Dirk 1 Dini, Luciana 1 Dudek-Peric, Aleksandra M 1 Faggioni, Alberto 1 Fucikova, Jitka 1 Gaipl, Udo S 1 Galluzzi, Lorenzo 1 Garg, Abhishek D 1 Golab, Jakub 1
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Pracoviště
BioTechMed Graz Graz Austria 1 Biotherapy and Vaccine Unit Institut ... 1 Cancer Gene Therapy Group Transplanta... 1 Cell Death Research and Therapy Labor... 1 Center of Clinical Investigations in ... 1 Centre Georges François Leclerc Dijon... 1 Centre de Recherche du Centre Hospita... 1 Department of Biological and Environm... 1 Department of Biomedical Molecular Bi... 1 Department of Ecological and Biologic... 1 Department of Experimental Medicine S... 1 Department of Gynaecology and Obstetr... 1 Department of Immunology 2nd Faculty ... 1 Department of Immunology Medical Univ... 1 Department of Internal Medicine 3 Rhe... 1 Department of Medical Oncology Univer... 1 Department of Microbiology Biochemist... 1 Department of Oncology University of ... 1 Department of Paediatric Haematology ... 1 Department of Radiation Oncology Klin... 1
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- Garg, Abhishek D
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Galluzzi, Lorenzo
Autor Galluzzi, Lorenzo Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers , Paris , France U1138, INSERM , Paris , France Université Paris Descartes, Sorbonne Paris Cité , Paris , France Université Pierre et Marie Curie , Paris , France Gustave Roussy Comprehensive Cancer Institute , Villejuif , France
- Apetoh, Lionel
- Baert, Thais
- Birge, Raymond B
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Bravo-San Pedro, José Manuel
Autor Bravo-San Pedro, José Manuel Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers , Paris , France U1138, INSERM , Paris , France Université Paris Descartes, Sorbonne Paris Cité , Paris , France Université Pierre et Marie Curie , Paris , France Gustave Roussy Comprehensive Cancer Institute , Villejuif , France
- Breckpot, Karine
- Brough, David
- Chaurio, Ricardo
- Cirone, Mara
Free Medical Journals od 2010
PubMed Central od 2010
Europe PubMed Central od 2010
Open Access Digital Library od 2010-01-01
Open Access Digital Library od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources od 2010
PubMed
26635802
DOI
10.3389/fimmu.2015.00588
Knihovny.cz E-zdroje
The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.