The intensity of antibody responses and level of protection against challenge infection induced by Actinobacillus pleuropneumoniae (APP) were compared in piglets vaccinated intramuscularly with different vaccination doses of a subunit vaccine. Secondary antibody responses to APP exotoxins induced by the intradermally administered diluted vaccines did not differ from those induced by undiluted vaccines administered either intradermally or intramuscularly. The level of protection measured by the clinical course of challenge infection to the extent of lung lesions was significantly higher in animals vaccinated with a three-time diluted vaccine in comparison with animals that were administered intramuscularly or intradermally with the most concentrated or the most diluted vaccines.

• MeSH
• Actinobacillus pleuropneumoniae imunologie   patogenita   MeSH
• bakteriální vakcíny aplikace a dávkování   imunologie   MeSH
• imunologická odpověď na dávku MeSH
• infekce bakteriemi rodu Actinobacillus imunologie   mikrobiologie   patologie   prevence a kontrola   MeSH
• injekce intradermální MeSH
• nemoci prasat imunologie   mikrobiologie   patologie   prevence a kontrola   MeSH
• plíce mikrobiologie   patologie   MeSH
• prasata MeSH
• protilátky bakteriální krev   MeSH
• výsledek terapie MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• práce podpořená grantem MeSH
• srovnávací studie MeSH