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Autor
Bachy, Emmanuel 1 Bargetzi, Mario 1 Boumendil, Ariane 1 Broom, Angus 1 Caillard, Sophie 1 Crawley, Charles 1 Damaj, Gandhi 1 De Wilde, Virginie 1 Eyre, Toby A 1 Finel, Herve 1 Hilgendorf, Inken 1 Kanfer, Edward 1 Kerre, Tessa 1 Kothari, Jaimal 1 Kozák, Tomáš 1 Montoto, Silvia 1 Robinson, Stephen 1 Tholouli, Eleni 1 Trappe, Ralf Ulrich 1 Trněný, Marek 1
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Pracoviště
BMT Unit University Hospital Bristol ... 1 Department of Haemato oncology St Bar... 1 Department of Haematology Addenbrooke... 1 Department of Haematology Cancer and ... 1 Department of Haematology Charles Uni... 1 Department of Haematology Ghent Unive... 1 Department of Haematology Hammersmith... 1 Department of Haematology Hospices Ci... 1 Department of Haematology Hospital Ce... 1 Department of Haematology Jena Univer... 1 Department of Haematology Kantonsspit... 1 Department of Haematology Western Gen... 1 Department of Hematology and Oncology... 1 Department of Hematology and Oncology... 1 Department of Internal Medicine 2 Hem... 1 Erasmus Hospital Route de Lennik 808 ... 1 Lymphoma Working Party EBMT Paris France 1 Manchester Royal Infirmary Oxford Roa... 1 Nephrology Transplantation Department... 1
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Autor
Bachy, Emmanuel 1 Bargetzi, Mario 1 Boumendil, Ariane 1 Broom, Angus 1 Caillard, Sophie 1 Crawley, Charles 1 Damaj, Gandhi 1 De Wilde, Virginie 1 Eyre, Toby A 1 Finel, Herve 1 Hilgendorf, Inken 1 Kanfer, Edward 1 Kerre, Tessa 1 Kothari, Jaimal 1 Kozák, Tomáš 1 Montoto, Silvia 1 Robinson, Stephen 1 Tholouli, Eleni 1 Trappe, Ralf Ulrich 1 Trněný, Marek 1
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Pracoviště
BMT Unit University Hospital Bristol ... 1 Department of Haemato oncology St Bar... 1 Department of Haematology Addenbrooke... 1 Department of Haematology Cancer and ... 1 Department of Haematology Charles Uni... 1 Department of Haematology Ghent Unive... 1 Department of Haematology Hammersmith... 1 Department of Haematology Hospices Ci... 1 Department of Haematology Hospital Ce... 1 Department of Haematology Jena Univer... 1 Department of Haematology Kantonsspit... 1 Department of Haematology Western Gen... 1 Department of Hematology and Oncology... 1 Department of Hematology and Oncology... 1 Department of Internal Medicine 2 Hem... 1 Erasmus Hospital Route de Lennik 808 ... 1 Lymphoma Working Party EBMT Paris France 1 Manchester Royal Infirmary Oxford Roa... 1 Nephrology Transplantation Department... 1
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- Eyre, Toby A
- Caillard, Sophie
- Finel, Herve
- Boumendil, Ariane
- Kothari, Jaimal
- Zimmermann, Heiner
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Trappe, Ralf Ulrich
Autor Trappe, Ralf Ulrich Department of Hematology and Oncology, DIAKO Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany Department of Internal Medicine II: Hematology and Oncology, University Medical Centre Schleswig-Holstein, Campus Kiel, Kiel, Germany Department of Hematology and Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany
- De Wilde, Virginie
- Tholouli, Eleni
- Kanfer, Edward
Freely Accessible Science Journals od 1997 do Před 1 rokem
ProQuest Central od 2000-01-01 do Před 1 rokem
Open Access Digital Library od 1997-01-01
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
PubMed
33864020
DOI
10.1038/s41409-021-01270-5
Knihovny.cz E-zdroje
Published data describing the efficacy and safety of autologous stem-cell transplantation (autoSCT) in post-transplant lymphoproliferative disorders (PTLD) is limited to case reports. This is a retrospective analysis of 21 patients reported to the EBMT registry who received an autoSCT for PTLD post solid organ transplant (SOT). Median age at autoSCT was 47 (range: 22-71) years. The commonest SOTs were kidney (48%) and liver (24%). Commonest histologies included DLBCL-type PTLD (14/21) and plasmacytoma-like PTLD (3/21). Patients received a median of two lines of therapy (range: 1-4) pre-autoSCT. ECOG performance status pre-autoSCT was 0 in 14% and 1 in 86%. Remission status pre-autoSCT was CR 47% and PR 38%. BEAM conditioning was used in 57% and high-dose melphalan in 10%. The median follow-up post-autoSCT was 64 months for alive patients. 3-year PFS was 62% [95% confidence interval (CI) 44-87%] and 3-year OS was 61% [95% CI:43-86]. There were 12 deaths, including four related to autoSCT. 100-day non-relapse-mortality (NRM) was 14% and 1-year NRM was 24%. This study suggests that autoSCT, although feasible and with potential therapeutic activity, is associated with a high NRM, primarily driven by infectious toxicity. A multi-disciplinary approach, expert microbiological input and stringent patient selection are required to optimise outcomes.
- MeSH
- autologní transplantace MeSH
- difúzní velkobuněčný B-lymfom * MeSH
- lidé MeSH
- lokální recidiva nádoru MeSH
- lymfoproliferativní nemoci * etiologie terapie MeSH
- retrospektivní studie MeSH
- transplantace hematopoetických kmenových buněk * škodlivé účinky MeSH
- transplantace kmenových buněk MeSH
- transplantace orgánů * škodlivé účinky MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
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