Morphine alkaloids and some of its derivatives (morphine, codeine, thebaine, oripavine, hydrocodone, and oxycodone) were subjected to fermentations with six fungal strains. The alkaloids were transformed to a variety of products via biological oxidations, reductions, and oxidative demethylations. The strain Cunninghamella echinulata proved to be the most effective for demethylations of all of the above compounds, except for morphine. The time profile of the conversion of 3-[14CH3]thebaine to 3-[14CH3]northebaine by C. echinulata cultures was also determined.

• MeSH
• biotransformace MeSH
• Cunninghamella metabolismus   růst a vývoj   MeSH
• financování organizované MeSH
• kultivační média MeSH
• opiové alkaloidy chemická syntéza   MeSH