The intestine is a unique immune environment that must respond to infectious organisms but remain tolerant to commensal microbes and food antigens. However, the molecular mechanisms that regulate immune cell function in the intestine remain unclear. Here we identify the POK/ZBTB family transcription factor hypermethylated in cancer 1 (HIC1, ZBTB29) as a central component of immunity and inflammation in the intestine. HIC1 is specifically expressed in immune cells in the intestinal lamina propria (LP) in the steady state and mice with a T-cell-specific deletion of HIC1 have reduced numbers of T cells in the LP. HIC1 expression is regulated by the Vitamin A metabolite retinoic acid, as mice raised on a Vitamin A-deficient diet lack HIC1-positive cells in the intestine. HIC1-deficient T cells overproduce IL-17A in vitro and in vivo, and fail to induce intestinal inflammation, identifying a critical role for HIC1 in the regulation of T-cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions.

• MeSH
• homeostáza MeSH
• imunita MeSH
• interleukin-17 metabolismus   MeSH
• kultivované buňky MeSH
• myši transgenní MeSH
• myši MeSH
• regulace genové exprese MeSH
• represorové proteiny metabolismus   MeSH
• sliznice fyziologie   MeSH
• střeva fyziologie   MeSH
• T-lymfocyty fyziologie   MeSH
• transkripční faktory Krüppel-like genetika   metabolismus   MeSH
• tretinoin metabolismus   MeSH
• zánět imunologie   MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH