- Autor
-
Pracoviště
Department of Chemistry University of... 1 Department of Chemistry University of... 1 Department of Molecular Sciences Macq... 1 ISIS Neutron and Muon Source Rutherfo... 1 Institute of Organic Chemistry and Bi... 1 Manchester Institute of Biotechnology... 1 School of Chemistry University of Bri... 1 School of Chemistry University of Sou... 1 School of Science RMIT University GPO... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Autor
-
Pracoviště
Department of Chemistry University of... 1 Department of Chemistry University of... 1 Department of Molecular Sciences Macq... 1 ISIS Neutron and Muon Source Rutherfo... 1 Institute of Organic Chemistry and Bi... 1 Manchester Institute of Biotechnology... 1 School of Chemistry University of Bri... 1 School of Chemistry University of Sou... 1 School of Science RMIT University GPO... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
NLK
Medline Complete (EBSCOhost)
od 2012-06-18 do Před 1 rokem
PubMed
33411956
DOI
10.1002/cbic.202000834
Knihovny.cz E-zdroje
The increase in resistant bacterial strains necessitates the identification of new antimicrobial molecules. Antimicrobial peptides (AMPs) are an attractive option because of evidence that bacteria cannot easily develop resistance to AMPs. The peptaibols, a class of naturally occurring AMPs, have shown particular promise as antimicrobial drugs, but their development has been hindered by their mechanism of action not being clearly understood. To explore how peptaibols might interact with membranes, circular dichroism, vibrational circular dichroism, linear dichroism, Raman spectroscopy, Raman optical activity, neutron reflectivity and molecular dynamics simulations have been used to study a small library of peptaibol mimics, the Aib-rich peptides. All the peptides studied quickly partitioned and oriented in membranes, and we found evidence of chiral interactions between the phospholipids and membrane-embedded peptides. The protocols presented in this paper open new ground by showing how chiro-optical spectroscopies can throw light on the mechanism of action of AMPs.
- MeSH
- cirkulární dichroismus MeSH
- fosfatidylcholiny chemie MeSH
- kationické antimikrobiální peptidy chemie metabolismus MeSH
- lipidové dvojvrstvy chemie metabolismus MeSH
- peptaiboly chemie metabolismus MeSH
- simulace molekulární dynamiky * MeSH
- stereoizomerie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.