BACKGROUND: Diabetic nephropathy (DN) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Several lines of evidence implicate the endothelin (ET) system in the pathophysiology of DN. The aim of the present study was to analyze if genetic polymorphisms of the ET-1 (EDN1) gene affect susceptibility to DN in Caucasians with T2DM. MATERIALS AND METHODS: The study population consisted of 651 Caucasian subjects with T2DM of more than 10 years' duration: 276 patients with DN (cases) and 375 patients without evidence of DN (controls). Polymorphisms in ET-1 (EDN1) gene, rs5370, rs1476046, and rs3087459, were studied. RESULTS: Genotype distributions of the studied polymorphisms showed no significant difference between cases and controls. CONCLUSIONS: We provide evidence that the rs5370, rs1476046, and rs3087459 polymorphisms of EDN1 gene are not risk factors for DN in Caucasians with T2DM.
- MeSH
- běloši genetika MeSH
- diabetes mellitus 2. typu etnologie genetika patofyziologie MeSH
- diabetické nefropatie etnologie genetika patofyziologie MeSH
- dospělí MeSH
- endotelin-1 genetika MeSH
- genetická predispozice k nemoci epidemiologie MeSH
- hodnocení rizik MeSH
- lidé středního věku MeSH
- lidé MeSH
- polymorfismus genetický * MeSH
- průřezové studie MeSH
- referenční hodnoty MeSH
- retrospektivní studie MeSH
- senzitivita a specificita MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
