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Autor
Baldus, Claudia D 1 Berdel, Wolfgang E 1 Bornhäuser, Martin 1 Brümmendorf, Tim H 1 Burchert, Andreas 1 Crysandt, Martina 1 Eckardt, Jan-Niklas 1 Ehninger, Gerhard 1 Einsele, Hermann 1 Hanoun, Maher 1 Herbst, Regina 1 Hochhaus, Andreas 1 Hänel, Mathias 1 Jöhrens, Korinna 1 Kaiser, Ulrich 1 Kaufmann, Martin 1 Krause, Stefan W 1 Kroschinsky, Frank 1 Krämer, Alwin 1 Kuithan, Friederike 1
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DKMS Clinical Trials Unit Dresden Ger... 1 Department of Hematology Oncology Hem... 1 Department of Hematology Oncology and... 1 Department of Hematology Oncology and... 1 Department of Hematology Oncology and... 1 Department of Hematology University H... 1 Department of Internal Medicine 1 Uni... 1 Department of Internal Medicine 2 Jen... 1 Department of Internal Medicine 5 Par... 1 Department of Internal Medicine Hemat... 1 Department of Internal Medicine Unive... 1 Department of Medicine A University H... 1 Department of Pathology University Ho... 1 German Cancer Research Center and Med... 1 German Consortium for Translational C... 1 Medical Care Center University Hospit... 1 Medical Clinic 1 Hematology and Cellt... 1 Medical Clinic 2 St Bernward Hospital... 1 Medical Clinic 2 University Hospital ... 1 Medical Clinic 3 Chemnitz Hospital AG... 1
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Autor
Baldus, Claudia D 1 Berdel, Wolfgang E 1 Bornhäuser, Martin 1 Brümmendorf, Tim H 1 Burchert, Andreas 1 Crysandt, Martina 1 Eckardt, Jan-Niklas 1 Ehninger, Gerhard 1 Einsele, Hermann 1 Hanoun, Maher 1 Herbst, Regina 1 Hochhaus, Andreas 1 Hänel, Mathias 1 Jöhrens, Korinna 1 Kaiser, Ulrich 1 Kaufmann, Martin 1 Krause, Stefan W 1 Kroschinsky, Frank 1 Krämer, Alwin 1 Kuithan, Friederike 1
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Pracoviště
DKMS Clinical Trials Unit Dresden Ger... 1 Department of Hematology Oncology Hem... 1 Department of Hematology Oncology and... 1 Department of Hematology Oncology and... 1 Department of Hematology Oncology and... 1 Department of Hematology University H... 1 Department of Internal Medicine 1 Uni... 1 Department of Internal Medicine 2 Jen... 1 Department of Internal Medicine 5 Par... 1 Department of Internal Medicine Hemat... 1 Department of Internal Medicine Unive... 1 Department of Medicine A University H... 1 Department of Pathology University Ho... 1 German Cancer Research Center and Med... 1 German Consortium for Translational C... 1 Medical Care Center University Hospit... 1 Medical Clinic 1 Hematology and Cellt... 1 Medical Clinic 2 St Bernward Hospital... 1 Medical Clinic 2 University Hospital ... 1 Medical Clinic 3 Chemnitz Hospital AG... 1
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BioMedCentral Open Access od 2008
Directory of Open Access Journals od 2008
Free Medical Journals od 2008
PubMed Central od 2008
Europe PubMed Central od 2008
ProQuest Central od 2009-01-01
Open Access Digital Library od 2008-01-01
Open Access Digital Library od 2008-01-01
Medline Complete (EBSCOhost) od 2009-01-17
Health & Medicine (ProQuest) od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources od 2008
Springer Journals Complete - Open Access od 2008-12-01
Springer Nature OA/Free Journals od 2008-12-01
PubMed
35562747
DOI
10.1186/s13045-022-01267-7
Knihovny.cz E-zdroje
BACKGROUND: Extramedullary manifestations (EM) are rare in acute myeloid leukemia (AML) and their impact on clinical outcomes is controversially discussed. METHODS: We retrospectively analyzed a large multi-center cohort of 1583 newly diagnosed AML patients, of whom 225 (14.21%) had EM. RESULTS: AML patients with EM presented with significantly higher counts of white blood cells (p < 0.0001), peripheral blood blasts (p < 0.0001), bone marrow blasts (p = 0.019), and LDH (p < 0.0001). Regarding molecular genetics, EM AML was associated with mutations of NPM1 (OR: 1.66, p < 0.001), FLT3-ITD (OR: 1.72, p < 0.001) and PTPN11 (OR: 2.46, p < 0.001). With regard to clinical outcomes, EM AML patients were less likely to achieve complete remissions (OR: 0.62, p = 0.004), and had a higher early death rate (OR: 2.23, p = 0.003). Multivariable analysis revealed EM as an independent risk factor for reduced overall survival (hazard ratio [HR]: 1.43, p < 0.001), however, for patients who received allogeneic hematopoietic cell transplantation (HCT) survival did not differ. For patients bearing EM AML, multivariable analysis unveiled mutated TP53 and IKZF1 as independent risk factors for reduced event-free (HR: 4.45, p < 0.001, and HR: 2.05, p = 0.044, respectively) and overall survival (HR: 2.48, p = 0.026, and HR: 2.63, p = 0.008, respectively). CONCLUSION: Our analysis represents one of the largest cohorts of EM AML and establishes key molecular markers linked to EM, providing new evidence that EM is associated with adverse risk in AML and may warrant allogeneic HCT in eligible patients with EM.
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