• Publikační typ
• časopisecké články MeSH
• tisková chyba MeSH

Vga(A) protein variants confer different levels of resistance to lincosamides, streptogramin A, and pleuromutilins (LSAP) by displacing antibiotics from the ribosome. Here, we show that expression of vga(A) variants from Staphylococcus haemolyticus is regulated by cis-regulatory RNA in response to the LSAP antibiotics by the mechanism of ribosome-mediated attenuation. The specificity of induction depends on Vga(A)-mediated resistance rather than on the sequence of the riboregulator. Fine tuning between Vga(A) activity and its expression in response to the antibiotics may contribute to the selection of more potent Vga(A) variants because newly acquired mutation can be immediately phenotypically manifested.

• MeSH
• antibakteriální látky farmakologie   MeSH
• bakteriální proteiny genetika   MeSH
• linkosamidy MeSH
• makrolidy MeSH
• mnohočetná bakteriální léková rezistence * MeSH
• ribozomy genetika   MeSH
• streptogramin A * MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH