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Autor: Patel, D

4 záznamů v Medvik Filtry

Článek

High-fructose diet-induced hypertriglyceridemia is associated with enhanced hepatic expression of ACAT2 in rats

Ichigo, Y
Autor Ichigo, Y Division of Life Science for Food, Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, Yanagido, Gifu, Japan
Takeshita, A
Autor Takeshita, A Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan
Hibino, M
Autor Hibino, M Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan
Nakagawa, T
Autor Nakagawa, T Division of Life Science for Food, Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, Yanagido, Gifu, Japan Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan
Hayakawa, T
Autor Hayakawa, T Division of Life Science for Food, Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, Yanagido, Gifu, Japan Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan
Patel, D
Autor Patel, D Department of Agricultural, Food and Nutritional Science, Li Ka Shing Center for Health Research Innovation, University of Alberta, Edmonton, Canada
Field, C. J
Autor Field, C. J Department of Agricultural, Food and Nutritional Science, Li Ka Shing Center for Health Research Innovation, University of Alberta, Edmonton, Canada
Shimada, M
Autor Shimada, M Division of Life Science for Food, Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, Yanagido, Gifu, Japan Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan Department of Agricultural, Food and Nutritional Science, Li Ka Shing Center for Health Research Innovation, University of Alberta, Edmonton, Canada

Physiological research. 2019 ; 68 (6) : 1021-1026. [pub] 20191025

Physiol. Res. (Print)
ISSN 1802-9973
Medvik
Zdroj

High levels of fructose induce hypertriglyceridemia, characterized by excessive levels of triglyceride-rich lipoproteins such as very low-density lipoprotein (VLDL); however, the underlying mechanisms are poorly understood. The aim of this short communication was to examine hepatic changes in the expression of genes related to cholesterol metabolism in rats with hypertriglyceridemia induced by high-fructose or high-glucose diets. Rats were fed a 65 % (w/w) glucose diet or a 65 % (w/w) fructose diet for 12 days. Serum levels of triglycerides, total cholesterol, and VLDL+LDL-cholesterol, hepatic levels of triglycerides and cholesterol, and ACAT2 expression at the gene and protein levels were significantly higher in the fructose diet group compared to the glucose diet group. The hepatic levels of Abcg5/8 were lower in the fructose group than in the glucose group. Serum high-density lipoprotein (HDL)-cholesterol and hepatic expression levels of Hmgcr, Ldlr, Acat1, Mttp, Apob, and Cyp7a1 did not differ significantly between groups. These findings suggest that high-fructose diet-induced hypertriglyceridemia is associated with increased hepatic ACAT2 expression.