Human DHRS7 (SDR34C1) is one of insufficiently described enzymes of the short-chain dehydrogenase/reductase superfamily. The members of this superfamily often play an important pato/physiological role in the human body, participating in the metabolism of diverse substrates (e.g. retinoids, steroids, xenobiotics). A systematic approach to the identification of novel, physiological substrates of DHRS7 based on a combination of homology modeling, structure-based virtual screening and experimental evaluation has been used. Three novel substrates of DHRS7 (dihydrotestosterone, benzil and 4,4'-dimetylbenzil) have been described.

• MeSH
• dihydrotestosteron metabolismus   MeSH
• fenylglyoxal analogy a deriváty   metabolismus   MeSH
• konformace proteinů MeSH
• lidé MeSH
• oxidoreduktasy chemie   metabolismus   MeSH
• simulace molekulového dockingu MeSH
• vazba proteinů MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH