A lot of hope for high-risk cancers is being pinned on immunotherapy but the evidence in children is lacking due to the rarity and limited efficacy of single-agent approaches. Here, we aim to assess the effectiveness of multimodal therapy comprising a personalized dendritic cell (DC) vaccine in children with relapsed and/or high-risk solid tumors using the N-of-1 approach in real-world scenario. A total of 160 evaluable events occurred in 48 patients during the 4-year follow-up. Overall survival of the cohort was 7.03 years. Disease control after vaccination was achieved in 53.8% patients. Comparative survival analysis showed the beneficial effect of DC vaccine beyond 2 years from initial diagnosis (HR = 0.53, P = .048) or in patients with disease control (HR = 0.16, P = .00053). A trend for synergistic effect with metronomic cyclophosphamide and/or vinblastine was indicated (HR = 0.60 P = .225). A strong synergistic effect was found for immune check-point inhibitors (ICIs) after priming with the DC vaccine (HR = 0.40, P = .0047). In conclusion, the personalized DC vaccine was an effective component in the multimodal individualized treatment. Personalized DC vaccine was effective in less burdened or more indolent diseases with a favorable safety profile and synergized with metronomic and/or immunomodulating agents.
- MeSH
- cyklofosfamid * terapeutické užití aplikace a dávkování MeSH
- dendritické buňky * imunologie MeSH
- dítě MeSH
- imunoterapie metody MeSH
- individualizovaná medicína * metody MeSH
- inhibitory kontrolních bodů terapeutické užití MeSH
- kojenec MeSH
- kombinovaná terapie MeSH
- lidé MeSH
- metronomické podávání léků MeSH
- mladiství MeSH
- nádory * mortalita imunologie terapie farmakoterapie MeSH
- následné studie MeSH
- předškolní dítě MeSH
- protinádorové vakcíny * aplikace a dávkování terapeutické užití MeSH
- vinblastin aplikace a dávkování terapeutické užití MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
