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CHU de Dijon EA 4184 University of Bu... 1 CNAM Université Paris 13) 93017 Paris... 1 Cancer Prevention Institute of Califo... 1 Centre Léon Bérard UMR CNRS 5239 Univ... 1 City of Hope National Medical Center ... 1 Clarient Pathology Services Aliso Vie... 1 Department of Human Genetics and Dise... 1 Genome Quebec Montreal Canada H3A 0G1 1 German Cancer Research Centre D 69120... 1 IDIBELL Institut Català d'Oncologia 8... 1 INRA 1 INSERM U557 (UMR Inserm 1 Icahn School of Medicine at Mount Sin... 1 Institute of Occupational Health Univ... 1 International Agency for Research on ... 1 Karolinska Institutet and Karolinska ... 1 MD Anderson Cancer Center University ... 1 MRC University of Glasgow Centre for ... 1 Masaryk Memorial Cancer Institute 656... 1 Mayo Clinic Rochester Minnesota 55905... 1
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CHU de Dijon EA 4184 University of Bu... 1 CNAM Université Paris 13) 93017 Paris... 1 Cancer Prevention Institute of Califo... 1 Centre Léon Bérard UMR CNRS 5239 Univ... 1 City of Hope National Medical Center ... 1 Clarient Pathology Services Aliso Vie... 1 Department of Human Genetics and Dise... 1 Genome Quebec Montreal Canada H3A 0G1 1 German Cancer Research Centre D 69120... 1 IDIBELL Institut Català d'Oncologia 8... 1 INRA 1 INSERM U557 (UMR Inserm 1 Icahn School of Medicine at Mount Sin... 1 Institute of Occupational Health Univ... 1 International Agency for Research on ... 1 Karolinska Institutet and Karolinska ... 1 MD Anderson Cancer Center University ... 1 MRC University of Glasgow Centre for ... 1 Masaryk Memorial Cancer Institute 656... 1 Mayo Clinic Rochester Minnesota 55905... 1
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Nature Open Access od 2010-12-01
PubMed Central od 2012
Europe PubMed Central od 2012
ProQuest Central od 2010-01-01
Medline Complete (EBSCOhost) od 2012-11-01
Health & Medicine (ProQuest) od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources od 2010
PubMed
24920014
DOI
10.1038/ncomms4856
Knihovny.cz E-zdroje
Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI) = 0.76-0.86, P(combined) = 3.5 × 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.
- MeSH
- celogenomová asociační studie MeSH
- dospělí MeSH
- genetická predispozice k nemoci * MeSH
- genetická variace MeSH
- Hodgkinova nemoc genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- lidské chromozomy, pár 19 genetika MeSH
- mladiství MeSH
- mladý dospělý MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- transkripční faktory bHLH genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
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