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Autor
Andersson, Alma 1 Astrup, Arne 1 Bhalla, Nayanika 1 Blaak, Ellen E 1 Blüher, Matthias 1 Buggert, Marcus 1 Bäckdahl, Jesper 1 Elmastas, Merve 1 Frendo-Cumbo, Scott 1 Jalkanen, Jutta 1 Kerr, Alastair G 1 Kublickiene, Karolina 1 Langin, Dominique 1 Laurencikiene, Jurga 1 Lourda, Magda 1 Massier, Lucas 1 Mejhert, Niklas 1 Nono Nankam, Pamela A 1 Rydén, Mikael 1 Sekine, Takuya 1
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Pracoviště
Center for Infectious Medicine Depart... 1 Childhood Cancer Research Unit Depart... 1 Department of Clinical Science Interv... 1 Department of Human Biology NUTRIM Sc... 1 Department of Medicine Huddinge Karol... 1 Department of Metabolic Health Nestle... 1 Department of Obesity and Nutritional... 1 Franco Czech Laboratory for Clinical ... 1 Helmholtz Institute for Metabolic Obe... 1 Institut Universitaire de France Pari... 1 Institute of Metabolic and Cardiovasc... 1 Laboratoire de biochimie Centre Hospi... 1 Laboratory of Translational Nutrition... 1 Medical Department 3 Endocrinology Ne... 1 Science for Life Laboratory Departmen... 1
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Autor
Andersson, Alma 1 Astrup, Arne 1 Bhalla, Nayanika 1 Blaak, Ellen E 1 Blüher, Matthias 1 Buggert, Marcus 1 Bäckdahl, Jesper 1 Elmastas, Merve 1 Frendo-Cumbo, Scott 1 Jalkanen, Jutta 1 Kerr, Alastair G 1 Kublickiene, Karolina 1 Langin, Dominique 1 Laurencikiene, Jurga 1 Lourda, Magda 1 Massier, Lucas 1 Mejhert, Niklas 1 Nono Nankam, Pamela A 1 Rydén, Mikael 1 Sekine, Takuya 1
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Pracoviště
Center for Infectious Medicine Depart... 1 Childhood Cancer Research Unit Depart... 1 Department of Clinical Science Interv... 1 Department of Human Biology NUTRIM Sc... 1 Department of Medicine Huddinge Karol... 1 Department of Metabolic Health Nestle... 1 Department of Obesity and Nutritional... 1 Franco Czech Laboratory for Clinical ... 1 Helmholtz Institute for Metabolic Obe... 1 Institut Universitaire de France Pari... 1 Institute of Metabolic and Cardiovasc... 1 Laboratoire de biochimie Centre Hospi... 1 Laboratory of Translational Nutrition... 1 Medical Department 3 Endocrinology Ne... 1 Science for Life Laboratory Departmen... 1
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NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
PubMed
36922516
DOI
10.1038/s41467-023-36983-2
Knihovny.cz E-zdroje
To date, single-cell studies of human white adipose tissue (WAT) have been based on small cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a comprehensive meta-analysis of publicly available and newly generated single-cell, single-nucleus, and spatial transcriptomic results from human subcutaneous, omental, and perivascular WAT. Our high-resolution map is built on data from ten studies and allowed us to robustly identify >60 subpopulations of adipocytes, fibroblast and adipogenic progenitors, vascular, and immune cells. Using these results, we deconvolved spatial and bulk transcriptomic data from nine additional cohorts to provide spatial and clinical dimensions to the map. This identified cell-cell interactions as well as relationships between specific cell subtypes and insulin resistance, dyslipidemia, adipocyte volume, and lipolysis upon long-term weight changes. Altogether, our meta-map provides a rich resource defining the cellular and microarchitectural landscape of human WAT and describes the associations between specific cell types and metabolic states.
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