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Department of Biology Faculty of Arts... 1 Department of Cytokinetics Institute ... 1 Department of Histology and Embryolog... 1 Department of Human Pharmacology and ... 1 Department of Human Pharmacology and ... 1 Department of Natural Drugs Faculty o... 1 International Clinical Research Cente... 1 NCC Nature Conservation Center Americ... 1
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Pracoviště
Department of Biology Faculty of Arts... 1 Department of Cytokinetics Institute ... 1 Department of Histology and Embryolog... 1 Department of Human Pharmacology and ... 1 Department of Human Pharmacology and ... 1 Department of Natural Drugs Faculty o... 1 International Clinical Research Cente... 1 NCC Nature Conservation Center Americ... 1
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Hindawi Publishing Open Access od 2004-01-01
PubMed Central od 2004
Europe PubMed Central od 2004
ProQuest Central od 2011-01-01
Open Access Digital Library od 2004-01-01
Open Access Digital Library od 2004-01-01
Open Access Digital Library od 2004-01-01
CINAHL Plus with Full Text (EBSCOhost) od 2008-03-01
Nursing & Allied Health Database (ProQuest) od 2011-01-01
Health & Medicine (ProQuest) od 2011-01-01
Psychology Database (ProQuest) od 2011-01-01
PubMed
23762124
DOI
10.1155/2013/350519
Knihovny.cz E-zdroje
Morus alba L. (MA) is a natural source of many compounds with different biological effects. It has been described to possess anti-inflammatory, antioxidant, and hepatoprotective activities. The aim of this study was to evaluate cytotoxicity of three flavonoids isolated from MA (kuwanon E, cudraflavone B, and 4'-O-methylkuwanon E) and to determine their effects on proliferation of THP-1 cells, and on cell cycle progression of cancer cells. Anti-inflammatory effects were also determined for all three given flavonoids. Methods used in the study included quantification of cells by hemocytometer and WST-1 assays, flow cytometry, western blotting, ELISA, and zymography. From the three compounds tested, cudraflavone B showed the strongest effects on cell cycle progression and viability of tumor and/or immortalized cells and also on inflammatory response of macrophage-like cells. Kuwanon E and 4'-O-methylkuwanon E exerted more sophisticated rather than direct toxic effect on used cell types. Our data indicate that mechanisms different from stress-related or apoptotic signaling pathways are involved in the action of these compounds. Although further studies are required to precisely define the mechanisms of MA flavonoid action in human cancer and macrophage-like cells, here we demonstrate their effects combining antiproliferative and anti-inflammatory activities, respectively.
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E-zdroje NLK Online
Directory of Open Access Journals od 2001Free Medical Journals od 1998
Medline Complete (EBSCOhost) od 2007-06-01
ROAD: Directory of Open Access Scholarly Resources od 2001
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