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Autor
Aguiar, Eric R G R 1 Borely, Daniel 1 Brandão-Filho, Sinval P 1 Brazil, Reginaldo Peçanha 1 Bruno, Rafaela V 1 Burleigh, Barbara A 1 Carvalho-Costa, Filipe A 1 Pessoa, Felipe A C 1 Pitaluga, André N 1 Salomón, Oscar D 1 Tempone, Antonio J 1 Traub-Cseko, Yara M 1 Volf, Petr 1 Zezza-Ramalho, Monique de Souza 1
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Pracoviště
Departamento de Bioquímica e Imunolog... 1 Departamento de Imunologia Instituto ... 1 Department of Immunology and Infectio... 1 Department of Parasitology Charles Un... 1 Instituto Nacional de Ciência e Tecno... 1 Instituto Nacional de Medicina Tropic... 1 Laboratório de Biologia Molecular de ... 1 Laboratório de Biologia Molecular de ... 1 Laboratório de Doenças Parasitárias I... 1 Laboratório de Ecologia de Doenças Tr... 1 Laboratório de Epidemiologia e Sistem... 1
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Autor
Aguiar, Eric R G R 1 Borely, Daniel 1 Brandão-Filho, Sinval P 1 Brazil, Reginaldo Peçanha 1 Bruno, Rafaela V 1 Burleigh, Barbara A 1 Carvalho-Costa, Filipe A 1 Pessoa, Felipe A C 1 Pitaluga, André N 1 Salomón, Oscar D 1 Tempone, Antonio J 1 Traub-Cseko, Yara M 1 Volf, Petr 1 Zezza-Ramalho, Monique de Souza 1
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Pracoviště
Departamento de Bioquímica e Imunolog... 1 Departamento de Imunologia Instituto ... 1 Department of Immunology and Infectio... 1 Department of Parasitology Charles Un... 1 Instituto Nacional de Ciência e Tecno... 1 Instituto Nacional de Medicina Tropic... 1 Laboratório de Biologia Molecular de ... 1 Laboratório de Biologia Molecular de ... 1 Laboratório de Doenças Parasitárias I... 1 Laboratório de Ecologia de Doenças Tr... 1 Laboratório de Epidemiologia e Sistem... 1
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Free Medical Journals od 2009
PubMed Central od 2009
Europe PubMed Central od 2009
ProQuest Central od 2009-01-01
Open Access Digital Library od 2009-01-01
Open Access Digital Library od 2009-01-01
Health & Medicine (ProQuest) od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources od 2009
PubMed
38543761
DOI
10.3390/v16030395
Knihovny.cz E-zdroje
Sandflies are known vectors of leishmaniasis. In the Old World, sandflies are also vectors of viruses while little is known about the capacity of New World insects to transmit viruses to humans. Here, we relate the identification of RNA sequences with homology to rhabdovirus nucleocapsids (NcPs) genes, initially in the Lutzomyia longipalpis LL5 cell lineage, named NcP1.1 and NcP2. The Rhabdoviridae family never retrotranscribes its RNA genome to DNA. The sequences here described were identified in cDNA and DNA from LL-5 cells and in adult insects indicating that they are transcribed endogenous viral elements (EVEs). The presence of NcP1.1 and NcP2 in the L. longipalpis genome was confirmed in silico. In addition to showing the genomic location of NcP1.1 and NcP2, we identified another rhabdoviral insertion named NcP1.2. Analysis of small RNA molecules derived from these sequences showed that NcP1.1 and NcP1.2 present a profile consistent with elements targeted by primary piRNAs, while NcP2 was restricted to the degradation profile. The presence of NcP1.1 and NcP2 was investigated in sandfly populations from South America and the Old World. These EVEs are shared by different sandfly populations in South America while none of the Old World species studied presented the insertions.
- MeSH
- DNA MeSH
- leishmanióza * MeSH
- lidé MeSH
- Psychodidae * MeSH
- Rhabdoviridae * MeSH
- RNA MeSH
- zvířata MeSH
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- lidé MeSH
- zvířata MeSH
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- časopisecké články MeSH
- Geografické názvy
- Brazílie MeSH
- Jižní Amerika MeSH
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