Magnézium (Mg2+) je esenciálny minerál, ktorý sa podieľa na rôznych dôležitých biochemických reakciách v tele matky a plodu. Magnéziová deficiencia v tehotenstve by nemala byť podceňovaná. Počas tehotenstva sú zvýšené požiadavky na príjem magnézia. Hypomagneziémia pozorovaná na zvieracích modeloch umožňuje vyhodnotiť, do akej miery môže nedostatok magnézia ovplyvniť zdravie plodu u ľudí neskoršie v živote. Tento článok sumarizuje dôležitosť magnézia v tehotenstve, zmeny vo farmakokinetike magnézia a dôsledky magnéziovej deficiencie u matky a plodu. Cieľom článku je zodpovedať otázku, či je v tehotenstve potrebná suplementácia magnéziom a ak áno, v akom rozsahu.
Magnesium (Mg2+) is an essential mineral that participates in different and important biochemical reactions in the maternal body and in the foetus. Magnesium deficiency during pregnancy should not be underestimated. Requirements for magnesium are increased during pregnancy. The hypomagnesaemia observed in animal models provides the ability to evaluate to what extent the deficiency can influence human offspring later in life. This article summarizes the importance of magnesium in pregnancy, changes in magnesium pharmacokinetics, and consequences of maternal and foetal magnesium deficiency. The article aims to answer whether it is necessary to supplement with magnesium during pregnancy and, if so, to what extent.
- MeSH
- Magnesium administration & dosage pharmacology therapeutic use MeSH
- Humans MeSH
- Magnesium Deficiency * embryology etiology drug therapy prevention & control MeSH
- Dietary Supplements classification MeSH
- Pregnant People * MeSH
- Fetal Development MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
- MeSH
- Humans MeSH
- Magnesium Deficiency * diagnosis therapy MeSH
- Infant, Newborn, Diseases MeSH
- Infant, Newborn MeSH
- Check Tag
- Humans MeSH
- Infant, Newborn MeSH
- Publication type
- Review MeSH
- Keywords
- podpůrná léčba,
- MeSH
- Anemia chemically induced drug therapy MeSH
- Cytostatic Agents MeSH
- Denosumab administration & dosage adverse effects therapeutic use MeSH
- Extravasation of Diagnostic and Therapeutic Materials drug therapy MeSH
- Pharmaceutical Solutions therapeutic use MeSH
- Neoplasms * drug therapy complications MeSH
- Magnesium Deficiency chemically induced drug therapy MeSH
- Neutropenia drug therapy prevention & control MeSH
- Drug-Related Side Effects and Adverse Reactions drug therapy MeSH
- Protective Agents administration & dosage MeSH
- Probiotics therapeutic use MeSH
- Radiodermatitis chemically induced prevention & control MeSH
- Mouth Mucosa pathology drug effects MeSH
- MeSH
- Headache therapy MeSH
- Magnesium * therapeutic use MeSH
- Humans MeSH
- Magnesium Deficiency complications MeSH
- Fatigue therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Popular Work MeSH
BACKGROUND: Primary hypomagnesemia with secondary hypocalcemia (HSH) is a rare genetic disorder. Dysfunctional transient receptor potential melastatin 6 causes impaired intestinal absorption of magnesium, leading to low serum levels accompanied by hypocalcemia. Typical signs at initial manifestation are generalized seizures, tetany, and/or muscle spasms. CASE REPORT: We present a 5 w/o female manifesting tonic-clonic seizures. Laboratory tests detected severe hypomagnesemia and hypocalcemia. The molecular genetic analysis revealed two novel mutations within the TRPM6 gene c.3308dupC (p.Pro1104Thrfs*28) (p.P1104Tfs*28) and c.3958C>T (p.Gln1302*) (p.Q1302*) and the patient was successfully treated with Mg supplementation. CONCLUSION: Ion disbalance should be taken into account in the differential diagnosis of infantile seizures. Accurate diagnosis of HSH together with appropriate treatment are crucial to prevent irreversible neurological outcomes.
- MeSH
- Magnesium MeSH
- Hypercalciuria MeSH
- Hypocalcemia * genetics MeSH
- TRPM Cation Channels * genetics MeSH
- Humans MeSH
- Mutation MeSH
- Magnesium Deficiency * congenital genetics MeSH
- Nephrocalcinosis MeSH
- Renal Tubular Transport, Inborn Errors MeSH
- Seizures genetics MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
