- MeSH
- Anthropometry methods MeSH
- Nutrition Assessment MeSH
- Kwashiorkor diagnosis etiology MeSH
- Nutritional Support classification methods MeSH
- Malnutrition * diagnosis etiology classification therapy MeSH
- Nutrition Disorders diagnosis classification MeSH
- Protein-Energy Malnutrition diagnosis etiology MeSH
- Publication type
- Review MeSH
- MeSH
- Geriatric Assessment methods MeSH
- Cachexia etiology physiopathology MeSH
- Frail Elderly MeSH
- Kwashiorkor etiology physiopathology prevention & control MeSH
- Humans MeSH
- Protein-Energy Malnutrition etiology physiopathology prevention & control psychology MeSH
- Sarcopenia * etiology physiopathology prevention & control MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Muscular Disorders, Atrophic etiology physiopathology MeSH
- Check Tag
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Publication type
- Review MeSH
Úvod: U pacientov s onkologickým ochorením sú poruchy výživy rizikovým faktorom, ktoré komplikujú protinádorovú liečbu a výrazne skracujú prežívanie pacientov. V praxi je kľúčovou podmienkou úspechu posúdenie stavu výživy a včasná nutričná intervencia. Cieľ: Hlavným cieľom príspevku je objasniť postupy ošetrovateľských intervencií pri zabezpečení výživy pacienta s malnutríciou. Metódy: Hlavnou metódou je prípadová štúdia (case study). Výber respondenta bol zámerný. Kritériami výberu boli: pacient s onkologickou diagnózou a malnutríciou, ochotný spolupracovať. Do štúdie sme zaradili 68 ročného pacienta s karcinómom pažeráka. Pacient nám poskytol informácie o svojom zdravotnom stave dobrovoľne a súhlasil s ich spracovaním. Výsledky: Na základe nutričnej anamnézy, antropometrických meraní a laboratórnych vyšetrení bol nutričný stav pacienta vyhodnotený ako malnutrícia. V priebehu štyroch mesiacov sme ordinovanými nutričnými intervenciami - podávaním diéty č.1, tekutín, a nutridrinkov 6 až 8 denne cez perkutánnu endoskopickú gastrostómiu zabezpečovali uspokojovanie potreby výživy u pacienta. Telesnú hmotnosť pacienta sa nám podarilo stabilizovať na hodnote 65-62kg za sledované obdobie 4 mesiacov. Záver: Malnutrícia je najčastejšou sprievodnou diagnózou u onkologických pacientov. Napriek nutričným intervenciám sa stav výživy pacienta zhoršil a po 4 mesiacoch javil známky nádorovej kachexie, čo potvrdili laboratórne parametre.
Introduction: In patients with oncological disease are nutritional disorders a risk factor, which complicate anti-tumor treatment and significantly shorten the survival of patients. In practice, the key condition for success is the assessment of the nutritional status and early nutritional intervention. Objective: The main objective of the paper is explain the procedures of nursing interventions in ensuring the nutrition of a malnourished patient. Methods: The main method is a case study. The choice of the respondent was deliberate. These lection criteria were: a patient with an oncological diagnosis and malnutrition, willing to cooperate. We included a 68-year-old patient with esophageal cancer in the study. The patient provided us with information about his health condition voluntarily and agreed to its processing. Results: Based on nutritional anamnesis, anthropometric measurements and laboratory tests, the patient's nutritional status was evaluated as malnutrition. Over thecourse of five months, we ensured that the patient's nutritional needs were met through a percutaneous endoscopic gastrostomy through prescribed nutritional interventions - administration of diet No. 1 and, liquids, 6 to 8 nutridrinks per day. We managed to measure the patient's body weight stabilize at a value of 65-62kg for the monitored period of 4 months. Conclusion: Malnutrition is the most common accompanying diagnosis in oncology patients. Despite nutritional interventions with the nutritional status of the patient worsened and after 4 months showed signs of tumor cachexia, which was confirmed by laboratory parameters.
- Keywords
- Perkutánní endoskopická gastrostomie (PEG),
- MeSH
- Enteral Nutrition MeSH
- Gastrostomy methods MeSH
- Nutrition Assessment MeSH
- Feeding Methods MeSH
- Minimally Invasive Surgical Procedures MeSH
- Neoplasms classification MeSH
- Nutritional Support MeSH
- Nutritional Status MeSH
- Nutrition Therapy MeSH
- Malnutrition diagnostic imaging diagnosis nursing therapy MeSH
- Protein-Energy Malnutrition diagnostic imaging diagnosis nursing therapy MeSH
- MeSH
- Gastrostomy MeSH
- Humans MeSH
- Mucositis etiology nursing therapy MeSH
- Head and Neck Neoplasms * drug therapy radiotherapy MeSH
- Drug-Related Side Effects and Adverse Reactions MeSH
- Deglutition Disorders etiology therapy MeSH
- Protein-Energy Malnutrition prevention & control therapy MeSH
- Radiotherapy adverse effects MeSH
- Check Tag
- Humans MeSH
- Keywords
- Cubitan, Nutryelt, Viant,
- MeSH
- Gastrostomy methods MeSH
- Cryotherapy methods MeSH
- Humans MeSH
- Mucositis * chemically induced classification prevention & control therapy MeSH
- Nutritional Support methods MeSH
- Food, Formulated MeSH
- Protein-Energy Malnutrition prevention & control therapy MeSH
- Antineoplastic Agents adverse effects therapeutic use MeSH
- Parenteral Nutrition Solutions MeSH
- Trace Elements therapeutic use MeSH
- Oral Sprays MeSH
- Check Tag
- Humans MeSH
- MeSH
- Enteral Nutrition MeSH
- Food, Fortified utilization MeSH
- Humans MeSH
- Neoplasms complications therapy MeSH
- Nutritional Support methods MeSH
- Nutrition Therapy methods MeSH
- Parenteral Nutrition MeSH
- Protein-Energy Malnutrition * prevention & control therapy MeSH
- Sarcopenia MeSH
- Check Tag
- Humans MeSH
Hapln4 is a link protein which stabilizes the binding between lecticans and hyaluronan in perineuronal nets (PNNs) in specific brain regions, including the medial nucleus of the trapezoid body (MNTB). The aim of this study was: (1) to reveal possible age-related alterations in the extracellular matrix composition in the MNTB and inferior colliculus, which was devoid of Hapln4 and served as a negative control, (2) to determine the impact of the Hapln4 deletion on the values of the ECS diffusion parameters in young and aged animals and (3) to verify that PNNs moderate age-related changes in the ECS diffusion, and that Hapln4-brevican complex is indispensable for the correct protective function of the PNNs. To achieve this, we evaluated the ECS diffusion parameters using the real-time iontophoretic method in the selected region in young adult (3 to 6-months-old) and aged (12 to 18-months-old) wild type and Hapln4 knock-out (KO) mice. The results were correlated with an immunohistochemical analysis of the ECM composition and astrocyte morphology. We report that the ECM composition is altered in the aged MNTB and aging is a critical point, revealing the effect of Hapln4 deficiency on the ECS diffusion. All of our findings support the hypothesis that the ECM changes in the MNTB of aged KO animals affect the ECS parameters indirectly, via morphological changes of astrocytes, which are in direct contact with synapses and can be influenced by the ongoing synaptic transmission altered by shifts in the ECM composition.
- MeSH
- Trapezoid Body metabolism pathology MeSH
- Diffusion * MeSH
- Extracellular Matrix Proteins deficiency MeSH
- Extracellular Matrix metabolism pathology MeSH
- Extracellular Space metabolism MeSH
- Mice, Inbred C57BL MeSH
- Mice, Knockout MeSH
- Mice MeSH
- Protein Deficiency metabolism pathology MeSH
- Organ Culture Techniques MeSH
- Peripheral Nerves metabolism pathology MeSH
- Nerve Tissue Proteins deficiency MeSH
- Auditory Pathways metabolism pathology MeSH
- Aging metabolism pathology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- MeSH
- Child MeSH
- Fatal Outcome MeSH
- Humans MeSH
- Lipopolysaccharides * deficiency MeSH
- Adolescent MeSH
- Protein Deficiency MeSH
- Immune System Diseases MeSH
- Child, Preschool MeSH
- Rare Diseases MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Biomarkers MeSH
- Energy Metabolism physiology MeSH
- Energy Intake MeSH
- Sports Nutritional Physiological Phenomena * MeSH
- Nutritional Physiological Phenomena MeSH
- Physical Conditioning, Human methods MeSH
- Humans MeSH
- Nutritional Requirements MeSH
- Nutritional Status MeSH
- Nutrition Therapy * methods MeSH
- Motor Activity physiology MeSH
- Dietary Supplements MeSH
- Protein-Energy Malnutrition diagnosis diet therapy MeSH
- Check Tag
- Humans MeSH
