We have reported the gateway reflex, which describes specific neural activations that regulate immune cell gateways at specific blood vessels in the central nervous system (CNS). Four types of gateway reflexes exist, all of which induce alterations in endothelial cells at specific vessels of the blood-brain barrier followed by inflammation in the CNS in the presence of CNS-autoreactive T cells. Here we report a new gateway reflex that suppresses the development of retinal inflammation by using an autoreactive T cell-mediated ocular inflammation model. Exposure to photopic light down-regulated the adrenoceptor pathway to attenuate ocular inflammation by suppressing breaching of the blood-retina barrier. Mechanistic analysis showed that exposure to photopic light down-regulates the expression of α1A-adrenoceptor (α1AAR) due to high levels of norepinephrine and epinephrine, subsequently suppressing inflammation. Surgical ablation of the superior cervical ganglion (SCG) did not negate the protective effect of photopic light, suggesting the involvement of retinal noradrenergic neurons rather than sympathetic neurons from the SCG. Blockade of α1AAR signaling under mesopic light recapitulated the protective effect of photopic light. Thus, targeting regional adrenoceptor signaling might represent a novel therapeutic strategy for autoimmune diseases including those that affect organs separated by barriers such as the CNS and eyes.

• MeSH
• adrenalin metabolismus   MeSH
• adrenergní látky metabolismus   MeSH
• adrenergní receptory metabolismus   MeSH
• alfa-1-adrenergní receptory metabolismus   MeSH
• autoimunita genetika   fyziologie   MeSH
• autoimunitní nemoci imunologie   MeSH
• centrální nervový systém metabolismus   MeSH
• endoteliální buňky metabolismus   MeSH
• ganglion cervicale superius metabolismus   MeSH
• hematoencefalická bariéra metabolismus   MeSH
• hematoretinální bariéra metabolismus   MeSH
• myši inbrední BALB C MeSH
• myši inbrední C57BL MeSH
• myši MeSH
• neurony metabolismus   MeSH
• noradrenalin metabolismus   MeSH
• retinitida patofyziologie   MeSH
• světlo MeSH
• T-lymfocyty imunologie   MeSH
• vidění barevné fyziologie   MeSH
• zánět metabolismus   MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH