Purinergic P2X receptors (P2XR), activated by extracellular adenosine 5‘-triphosphate (ATP), represent a specific type of li- gand-gated ion channels. They form functional trimeric homomers or heteromers which are nonselectively cation-perme- able after receptor activation. P2X receptors are widely expressed in excitable and nonexcitable tissues and are involved in many physiological and pathophysiological processes such as platelet aggregation, contraction of smooth muscle, immu- ne responses, cell proliferation and apoptosis or neurotransmission. In mammals, seven P2X subunits (P2X1-P2X7) have been identified. They differ mainly in distribution, pharmacological profile and kinetics of ATP-induced responses. The sub- type P2X7 is the most specific in the P2X family and widely differs from other P2X subtypes.
- Klíčová slova
- extracelulární ATP, purinergní P2X rodina, buněčná proliferace a apoptóza,
- MeSH
- adenosintrifosfát biosyntéza MeSH
- agonisté purinergního receptoru P2X farmakokinetika farmakologie MeSH
- apoptóza fyziologie MeSH
- extracelulární prostor MeSH
- fyziologie buňky MeSH
- lidé MeSH
- mezibuněčné signální peptidy a proteiny MeSH
- proliferace buněk MeSH
- purinergní receptory P2X * analýza biosyntéza fyziologie izolace a purifikace klasifikace metabolismus účinky léků MeSH
- purinergní receptory P2X1 krev MeSH
- purinergní receptory P2X3 fyziologie MeSH
- purinergní receptory P2X4 MeSH
- purinergní receptory P2X7 imunologie MeSH
- signální transdukce MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
