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MeSH: Ventricular Dysfunction, Left-diagnostic imaging

34 záznamů v Medvik Filtry

Článek online

Emergentní echokardiografie u nemocných s akutním srdečním selháním
[Emergency echocardiography in patients with acute heart failure]

Holaj, Robert, 1965-
Autor Autorita ORCID III. interni klinika, 1. lekařska fakulta Univerzity Karlovy a Všeobecna fakultni nemocnice v Praze

Intervenční a akutní kardiologie. 2024 ; 23 (1) : 17-20. [pub] 20240429

ISSN 1213-807X
Medvik
Zdroj

Transtorakální echokardiografické vyšetření (TTE) hraje nezastupitelnou úlohu při diagnostice příčiny akutního srdečního selhání. Při pátrání po srdeční dysfunkci by se mělo využít možnosti všech srdečních ultrazvukových zobrazovacích technik, včetně dvourozměrné/trojrozměrné echokardiografie, pulzního a kontinuálního vlnového dopplerovského zobrazení, barevného průtokového dopplerovského mapování, tkáňového dopplerovského zobrazování i deformační analýzy.

Transthoracic echocardiography (TTE) is the method of choice for assessment of myocardial systolic and diastolic function of both the left and right ventricles. Echocardiography is a term used here to refer to all cardiac ultrasound imaging techniques, including two-dimensional/three-dimensional echocardiography, pulsed and continuous wave Doppler, colour flow Doppler, tissue Doppler imaging, contrast echocardiography, and deformation imaging (strain and strain rate).

Článek online

Evolution and Prognostic Impact of Left Ventricular Myocardial Work Indices After Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis

Echocardiography. 2024 ; 41 (10) : e70006. [pub] -

ISSN 1540-8175
Medvik
Zdroj

PURPOSE: Left ventricular myocardial work (LVMW) has been shown to better characterize LV function in patients with severe aortic stenosis by correcting LV afterload. The aim of this study was to evaluate the evolution in LVMW indices after transcatheter aortic valve replacement (TAVR) and their prognostic value. METHODS: The following LVMW indices were calculated before and immediately after TAVR in 255 patients (median age 82 years, 51% male): global work index (GWI), global constructive work (GCW), global wasted work (GWW) and global work efficiency (GWE). The study endpoint was all-cause mortality. RESULTS: After TAVR, LV ejection fraction and LV global longitudinal strain (GLS) did not change significantly (from 56% to 55%, p = 0.470 and from 13.6% to 13.2%, p = 0.068). Concerning LVMW indices, while LV GWW remained unchanged after TAVR (from 247 to 258 mmHg%, p = 0.080), LV GWI, LV GCW, and LV GWE significantly decreased (from 1882 to 1291 mmHg%, p < 0.001, from 2248 to 1671 mmHg%, p < 0.001, and from 89% to 85%, p < 0.001, respectively). During a median follow-up of 59 [40-72] months, 129 patients died. After correcting for potential confounders (sex, diabetes, renal function, atrial fibrillation, Charlson comorbidity index, and pacemaker implantation post-TAVR), post-TAVR LV GLS, GWI, and GCW remained independently associated with all-cause mortality. However, post-TAVR LV GWI demonstrated the highest increase in model predictivity. CONCLUSION: In patients undergoing TAVR, LVMW parameters significantly change after intervention. LV GWI after TAVR showed the strongest association with all-cause mortality among both conventional and advanced parameters of LV systolic function both pre- and post-TAVR and might enable better risk stratification of these patients after intervention.

Článek online

Three-dimensional echocardiographic left ventricular strain analysis in Fabry disease: correlation with heart failure severity, myocardial scar, and impact on long-term prognosis

European heart journal cardiovascular Imaging. 2023 ; 24 (12) : 1629-1637. [pub] 2023Nov23

Eur Heart J Cardiovasc Imaging
ISSN 2047-2412
Medvik
Zdroj

AIMS: Fabry disease (FD) is a multisystemic lysosomal storage disorder caused by a defect in the alpha-galactosidase A gene that manifests as a phenocopy of hypertrophic cardiomyopathy. We assessed the echocardiographic 3D left ventricular (LV) strain of patients with FD in relation to heart failure severity using natriuretic peptides, the presence of a cardiovascular magnetic resonance (CMR) late gadolinium enhancement scar, and long-term prognosis. METHODS AND RESULTS: 3D echocardiography was feasible in 75/99 patients with FD [aged 47 ± 14 years, 44% males, LV ejection fraction (EF) 65 ± 6% and 51% with hypertrophy or concentric remodelling of the LV]. Long-term prognosis (death, heart failure decompensation, or cardiovascular hospitalization) was assessed over a median follow-up of 3.1 years. A stronger correlation was observed for N-terminal pro-brain natriuretic peptide levels with 3D LV global longitudinal strain (GLS, r = -0.49, P < 0.0001) than with 3D LV global circumferential strain (GCS, r = -0.38, P < 0.001) or 3D LVEF (r = -0.25, P = 0.036). Individuals with posterolateral scar on CMR had lower posterolateral 3D circumferential strain (CS; P = 0.009). 3D LV-GLS was associated with long-term prognosis [adjusted hazard ratio 0.85 (confidence interval 0.75-0.95), P = 0.004], while 3D LV-GCS and 3D LVEF were not (P = 0.284 and P = 0.324). CONCLUSION: 3D LV-GLS is associated with both heart failure severity measured by natriuretic peptide levels and long-term prognosis. Decreased posterolateral 3D CS reflects typical posterolateral scarring in FD. Where feasible, 3D-strain echocardiography can be used for a comprehensive mechanical assessment of the LV in patients with FD.

MeSH
dysfunkce levé srdeční komory * diagnostické zobrazování etiologie MeSH
echokardiografie trojrozměrná * metody MeSH
echokardiografie metody MeSH
Fabryho nemoc * komplikace diagnostické zobrazování MeSH
funkce levé komory srdeční MeSH
gadolinium MeSH
jizva diagnostické zobrazování MeSH
kontrastní látky MeSH
lidé MeSH
prognóza MeSH
reprodukovatelnost výsledků MeSH
srdeční selhání * diagnostické zobrazování etiologie MeSH
tepový objem MeSH
Check Tag
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH

Článek

Long-Term Results of Hybrid Left Ventricular Reconstruction in the Treatment of Ischemic Cardiomyopathy

Journal of cardiovascular translational research. 2021 ; 14 (6) : 1043-1050. [pub] 20210511

J Cardiovasc Transl Res
ISSN 1937-5395
Medvik
Zdroj

The evidence supporting surgical aneurysmectomy in ischemic heart failure is inconsistent. The aim of the study was to describe long-term effect of minimally invasive hybrid transcatheter and minithoracotomy left ventricular (LV) reconstruction in patients with ischemic cardiomyopathy. Twenty-three subjects with transmural anterior wall scarring, LV ejection fraction 15-45%, and New York Heart Association class ≥ II were intervened using Revivent TC anchoring system. LV end-systolic volume index was reduced from 73.2 ± 27 ml at baseline to 51.5 ± 22 ml after 6 months (p < 0.001), 49.9 ± 20 ml after 2 years (p < 0.001), and 56.1 ± 16 ml after 5 years (p = 0.047). NYHA class improved significantly at 5 years compared to baseline. Six-min walk test distance increased at 2 years compared to the 6-month visit. Hybrid LV reconstruction using the anchoring system provides significant and durable LV volume reduction during 5-year follow-up in preselected patients with ischemic heart failure. Legend: Hybrid left ventricular reconstruction using the anchoring system provides significant and durable LV volume reduction throughout 5-year follow-up in preselected patients with ischemic heart failure.

MeSH
dysfunkce levé srdeční komory diagnostické zobrazování chirurgie MeSH
ischemická choroba srdeční diagnostické zobrazování chirurgie MeSH
kardiochirurgické výkony metody MeSH
kardiomyopatie diagnostické zobrazování chirurgie MeSH
lidé středního věku MeSH
lidé MeSH
prospektivní studie MeSH
tepový objem MeSH
test chůzí MeSH
zákroky plastické chirurgie metody MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

Článek online

Left Ventricular Torsion Obtained Using Equilibrated Warping in Patients with Repaired Tetralogy of Fallot

Pediatric cardiology. 2021 ; 42 (6) : 1275-1283. [pub] 20210426

Pediatr Cardiol
ISSN 1432-1971
Medvik
Zdroj

Patients after surgical repair of Tetralogy of Fallot (rTOF) may suffer a decrease in left ventricular (LV) function. The aim of our study is to evaluate a novel method of assessing LV torsion in patients with rTOF, as an early indicator of systolic LV dysfunction. Motion tracking based on image registration regularized by the equilibrium gap principle, known as equilibrated warping, was employed to assess LV torsion. Seventy-six cases of rTOF and ten normal controls were included. The group of controls was assessed for reproducibility using both equilibrated warping and standard clinical tissue tracking software (CVI42, version 5.10.1, Calgary, Canada). Patients were dichotomized into two groups: normal vs. loss of torsion. Torsion by equilibrated warping was successfully obtained in 68 of 76 (89%) patients and 9 of 10 (90%) controls. For equilibrated warping, the intra- and interobserver coefficients of variation were 0.095 and 0.117, respectively, compared to 0.260 and 0.831 for tissue tracking by standard clinical software. The intra- and inter-observer intraclass correlation coefficients for equilibrated warping were 0.862 and 0.831, respectively, compared to 0.992 and 0.648 for tissue tracking. Loss of torsion was noted in 32 of the 68 (47%) patients with rTOF. There was no difference in LV or RV volumes or ejection fraction between these groups. The assessment of LV torsion by equilibrated warping is feasible and shows good reliability. Loss of torsion is common in patients with rTOF and its robust assessment might contribute into uncovering heart failure in an earlier stage.

MeSH
dítě MeSH
dospělí MeSH
dysfunkce levé srdeční komory diagnostické zobrazování patofyziologie MeSH
Fallotova tetralogie chirurgie MeSH
kojenec MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
počítačové zpracování obrazu metody MeSH
pooperační komplikace diagnostické zobrazování patofyziologie MeSH
předškolní dítě MeSH
reprodukovatelnost výsledků MeSH
retrospektivní studie MeSH
studie případů a kontrol MeSH
Check Tag
dítě MeSH
dospělí MeSH
kojenec MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
předškolní dítě MeSH
Publikační typ
časopisecké články MeSH

Článek online

Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients

Orphanet journal of rare diseases. 2021 ; 16 (1) : 57. [pub] 20210130

Orphanet J Rare Dis
ISSN 1750-1172
Medvik
Zdroj

BACKGROUND: Duchenne muscular dystrophy (DMD) manifests in males mainly by skeletal muscle impairment, but also by cardiac dysfunction. The assessment of the early phases of cardiac involvement using echocardiography is often very difficult to perform in these patients. The aim of the study was to use cardiac magnetic resonance (CMR) strain analysis and mitral annular plane systolic excursion (MAPSE) in the detection of early left ventricular (LV) dysfunction in DMD patients. METHODS AND RESULTS: In total, 51 male DMD patients and 18 matched controls were examined by CMR. MAPSE measurement and functional analysis using feature tracking (FT) were performed. Three groups of patients were evaluated: A/ patients with LGE and LV EF < 50% (n = 8), B/ patients with LGE and LVEF ≥ 50% (n = 13), and C/ patients without LGE and LVEF ≥ 50% (n = 30). MAPSE and global LV strains of the 3 DMD groups were compared to controls (n = 18). Groups A and B had significantly reduced values of MAPSE, global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in comparison to controls (p < 0.05). The values of MAPSE (11.6 ± 1.9 v 13.7 ± 2.7 mm) and GCS (- 26.2 ± 4.2 v - 30.0 ± 5.1%) were significantly reduced in group C compared to the controls (p < 0.05). CONCLUSION: DMD patients had decreased LV systolic function measured by MAPSE and global LV strain even in the case of normal LV EF and the absence of LGE. FT and MAPSE measurement provide sensitive assessment of early cardiac involvement in DMD patients.

MeSH
Duchennova muskulární dystrofie * diagnostické zobrazování MeSH
dysfunkce levé srdeční komory * diagnostické zobrazování MeSH
funkce levé komory srdeční MeSH
kardiomyopatie * MeSH
lidé MeSH
myokard MeSH
Check Tag
lidé MeSH
mužské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

Článek online

Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers

Scientific reports. 2020 ; 10 (1) : 20794. [pub] 20201127

Sci Rep
ISSN 2045-2322
Medvik
Zdroj

To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p < 0.001, 0.08 vs. 0.09 m/s, p < 0.01 and 0.13 vs. 0.14 m/s, p = 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p = 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.

Článek

Intenzifikace léčby, efekt GLP-1 analoga Ozempic v kombinaci s metforminem
[Intensification of treatment, the effect of GLP-1 receptor agonist (Ozempic) in combina-tion with metformin]

Markofová, Gita
Autor Autorita Diabetologické centrum Karlovarské krajské nemocnice

Kazuistiky v diabetologii. 2020 ; 18 (2) : 18-20.

ISSN 1214-231X
Medvik
Zdroj

Kazuistika popisuje příběh muže s kratší dobou trvání diabetu a s mnohočetnými rizikovýmifaktory. Jako lék druhé volby po selhání monoterapie metforminem byla doporučena léčbaGLP-1 analogem. V průběhu léčby semaglutidem došlo ke zlepšení kompenzace diabetu a re-dukci hmotnosti.

The case report describes a story of a man with a short-time duration of diabetes mellituswith multiple risk factors. We recommended GLP-1 receptor agonist treatment as a secondline drug after the metformin monotherapy failure. During the semaglutide treatment, dia-betes control and weight loss improved.