Cholestatická onemocnění jater se vyznačují progresivní povahou a omezenými možnostmi konzervativní léčby. Jedinou efektivní metodou léčby terminálního stadia je transplantace jater, která signifikantně prodlužuje dobu přežití pacientů. Transplantace jater je v současnosti indikována nejen u pacientů s chronickým jaterním selháním nebo hepatobiliární malignitou, ale také u pacientů se sníženou kvalitou života při symptomech z obstrukce žlučovodů. Péče po transplantaci jater je specifická zejména z důvodu přítomnosti imunitně asociovaných onemocnění, např. idiopatických střevních zánětů u pacientů s primární sklerozující cholangitidou. Rekurence základního onemocnění v jaterním štěpu je častou dlouhodobou komplikací, která může negativně ovlivnit přežití štěpu i celkovou délku života. Navzdory riziku rekurence jsou dlouhodobé výsledky transplantace jater pro cholestatické nemoci výborné, přičemž pacienti s těmito diagnózami dosahují delšího přežití ve srovnání s ostatními transplantovanými pacienty.

Cholestatic liver diseases are characterized by their progressive nature and limited conservative treatment options. Liver transplantation is the only effective method of treatment for the terminal stage. Before the era of liver transplantation, patients with cholestatic disease had a significantly reduced life expectancy. Liver transplantation is now indicated not only for patients with chronic liver failure or hepatobiliary malignancy, but also for those with reduced quality of life from cholestatic symptoms. Post-transplant care is particularly specific because of the presence of immune-associated diseases, such as inflammatory bowel disease in patients with primary sclerosing cholangitis. Recurrence of the underlying disease in the liver graft is a common long-term complication that can negatively affect graft survival and overall life expectancy. Despite the risk of recurrence, the long-term outcomes of liver transplantation for cholestatic disease are excellent, achieving longer survival compared to other transplant recipients.

• Keywords
• indikace k transplantaci,
• MeSH
• Cholangitis * complications   pathology   therapy   MeSH
• Inflammatory Bowel Diseases complications   therapy   MeSH
• Humans MeSH
• Cholangitis, Sclerosing complications   pathology   therapy   MeSH
• Liver Transplantation * MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• Keywords
• kyselina obeticholová,
• MeSH
• Liver Cirrhosis, Biliary * diagnosis   drug therapy   pathology   MeSH
• Cholangitis diagnosis   drug therapy   pathology   MeSH
• Gastroenterology MeSH
• Clinical Studies as Topic MeSH
• Middle Aged MeSH
• Humans MeSH
• Aged MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Case Reports MeSH
• News MeSH

• MeSH
• Cholecystitis, Acute drug therapy   pathology   MeSH
• Liver Diseases, Alcoholic drug therapy   pathology   MeSH
• Hepatitis, Autoimmune drug therapy   pathology   MeSH
• Liver Cirrhosis, Biliary drug therapy   pathology   MeSH
• Cholangitis drug therapy   parasitology   pathology   MeSH
• Cholelithiasis drug therapy   pathology   MeSH
• Biliary Dyskinesia drug therapy   MeSH
• Cholestasis, Extrahepatic drug therapy   pathology   MeSH
• Hemochromatosis drug therapy   congenital   MeSH
• Hepatolenticular Degeneration drug therapy   pathology   MeSH
• Chemical and Drug Induced Liver Injury MeSH
• Humans MeSH
• Liver Diseases drug therapy   MeSH
• Bile Duct Diseases drug therapy   MeSH
• Cholangitis, Sclerosing drug therapy   pathology   MeSH
• Fatty Liver drug therapy   pathology   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Liver Cirrhosis, Biliary complications   physiopathology   pathology   MeSH
• Cholangitis diagnosis   etiology   pathology   MeSH
• Cholecystectomy, Laparoscopic utilization   MeSH
• Iatrogenic Disease MeSH
• Humans MeSH
• Postoperative Complications etiology   pathology   MeSH
• Liver Transplantation pathology   utilization   MeSH
• Bile Ducts, Extrahepatic physiopathology   pathology   injuries   MeSH
• Bile Ducts injuries   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Acute Disease pathology   MeSH
• Anti-Bacterial Agents therapeutic use   MeSH
• Bacterial Infections pathology   MeSH
• Cholangitis etiology   classification   pathology   MeSH
• Cholestasis pathology   MeSH
• Disease Management MeSH
• Bile Duct Diseases diagnosis   pathology   therapy   MeSH

• MeSH
• Cholangitis diagnosis   pathology   MeSH
• Diagnostic Techniques, Digestive System methods   MeSH
• Adult MeSH
• Gastrointestinal Diseases diagnosis   pathology   MeSH
• Colorectal Neoplasms diagnosis   pathology   MeSH
• Humans MeSH
• Risk Factors MeSH
• Colitis, Ulcerative diagnosis   pathology   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Male MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Antibiotic Prophylaxis MeSH
• Bacteremia pathology   MeSH
• Cholangitis pathology   MeSH
• Endoscopy, Gastrointestinal methods   adverse effects   MeSH
• Risk Assessment MeSH
• Infections pathology   MeSH

• MeSH
• Cholangiography MeSH
• Cholangitis microbiology   pathology   MeSH
• Cholestasis microbiology   MeSH
• Premedication MeSH

• MeSH
• Cholangitis diagnosis   pathology   MeSH
• Hepatitis diagnosis   pathology   MeSH
• Biopsy, Needle MeSH
• Humans MeSH
• Check Tag
• Humans MeSH

• MeSH
• Cholangitis * complications   pathology   MeSH
• Cholecystitis complications   pathology   MeSH
• Liver Function Tests * methods   MeSH
• Clinical Studies as Topic MeSH
• Humans MeSH
• Check Tag
• Humans MeSH