- MeSH
- dítě MeSH
- fluoridy * škodlivé účinky toxicita MeSH
- glutathion nedostatek MeSH
- hliník škodlivé účinky toxicita MeSH
- lidé MeSH
- neurotoxiny škodlivé účinky toxicita MeSH
- oxidační stres MeSH
- poruchy autistického spektra * epidemiologie patofyziologie prevence a kontrola MeSH
- potravní doplňky MeSH
- registrace MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
The continuous rise of autism spectrum disorder (ASD) prevalent in the past few decades is causing an increase in public health and socioeconomic concern. A consensus suggests the involvement of both genetic and environmental factors in the ASD etiopathogenesis. Fluoride (F) is rarely recognized among the environmental risk factors of ASD, since the neurotoxic effects of F are not generally accepted. Our review aims to provide evidence of F neurotoxicity. We assess the risk of chronic F exposure in the ASD etiopathology and investigate the role of metabolic and mitochondrial dysfunction, oxidative stress and inflammation, immunoexcitotoxicity, and decreased melatonin levels. These symptoms have been observed both after chronic F exposure as well as in ASD. Moreover, we show that F in synergistic interactions with aluminum's free metal cation (Al3+) can reinforce the pathological symptoms of ASD. This reinforcement takes place at concentrations several times lower than when acting alone. A high ASD prevalence has been reported from countries with water fluoridation as well as from endemic fluorosis areas. We suggest focusing the ASD prevention on the reduction of the F and Al3+ burdens from daily life.
- MeSH
- fluoridy toxicita MeSH
- lidé MeSH
- neurotoxické syndromy epidemiologie etiologie MeSH
- poruchy autistického spektra epidemiologie etiologie MeSH
- rizikové faktory MeSH
- vystavení vlivu životního prostředí škodlivé účinky MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The objective of this study is to describe a case-series of potassium aluminium tetrafluoride (KAlF(4))-induced occupational asthma (OA) and/or occupational rhinitis (OR). The study involves five patients from a heat-exchanger production line who were examined (including specific inhalation challenge tests) for suspected OA and/or OR caused by a flux containing almost 100% KAlF(4) - with fluorides' workplace air concentrations ranging between 1.7 and 2.8 mg/m(3). No subject had a previous history of asthma. All five patients had a positive specific challenge test (three patients were diagnosed with OA alone, one with OR and one with both OR and OA). At the follow-up visit, after three years on average, all patients needed permanent corticosteroid therapy (four topical, one oral). After elimination from the exposure, only one of the observed subjects gave an indication of an improvement, two subjects stabilized and two worsened. Our case series focuses on the correlation between patients' exposure to fluorides in air-conditioner production and the subsequent occurrence of OR/OA. Currently, it is uncertain whether these OR/OA were caused by hypersensitivity or irritation.
- MeSH
- automobily MeSH
- dospělí MeSH
- fluoridy toxicita MeSH
- lidé středního věku MeSH
- lidé MeSH
- potřeby pro domácnost MeSH
- pracovní expozice škodlivé účinky MeSH
- profesionální astma chemicky indukované MeSH
- rinitida chemicky indukované MeSH
- sloučeniny draslíku toxicita MeSH
- sloučeniny hliníku toxicita MeSH
- zpracovatelský průmysl * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVE: Fluoride concentration in dentine has been recommended as the best marker for the level of chronic fluoride intake and the most suitable indicator of an individual's total body burden of fluoride. We analysed fluoride concentrations in the dentine of cheek teeth of European roe deer from fluoride-polluted habitats to retrospectively assess the level of fluoride uptake into the tissue. Thereby, we tested the hypothesis of the existence of mechanisms that limit fluoride intake of individuals and fluoride exposure of forming dental hard tissues during the late foetal and early postnatal periods in the species. DESIGN: Using electron-microprobe analysis, fluoride profiles were obtained on sectioned P(4)s, M(1)s, and M(3)s from individuals exhibiting pronounced dental fluorosis. Fluoride concentrations were compared between early formed (peripheral) and late-formed (juxtapulpal) dentine both within single teeth and amongst the three different teeth studied. RESULTS: Peripheral dentine of the M(1), which is formed during the late foetal and early postnatal periods, exhibited markedly lower fluoride concentrations than juxtapulpal dentine of the same tooth and both, peripheral and juxtapulpal dentine of P(4) and M(3) that are formed post-weaning. CONCLUSIONS: Our study provides strong support for the hypothesis that in the European roe deer the prenatal and early postnatal (pre-weaning) stages of dental development are (largely) protected against exposure to excess fluoride. This is attributed to the operation of certain protective mechanisms during these periods.
- MeSH
- biologické markery analýza MeSH
- dentální fluoróza klasifikace metabolismus MeSH
- dentin chemie MeSH
- fluoridy analýza toxicita MeSH
- látky znečišťující životní prostředí analýza MeSH
- mandibula chemie MeSH
- mikroanalýza elektronovou sondou MeSH
- moláry chemie MeSH
- obsah radioaktivních látek v organizmu MeSH
- odontogeneze fyziologie MeSH
- premolár chemie MeSH
- retrospektivní studie MeSH
- tkáňová distribuce MeSH
- vápník analýza MeSH
- vysoká zvěř MeSH
- vystavení vlivu životního prostředí MeSH
- zubní sklovina chemie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Geografické názvy
- Česká republika MeSH
Přes rozsáhlý výzkum zůstává etiopatogeneze poruch autistického spektra (PAS) nevysvětlená. Náš přehled přináší doklady o tom, že většina heterogenních symptomů PAS by mohla mít společné patofyziologické poruchy na buněčné úrovni spojené s dysregulací glutamátergní neurotransmise v mozku a excitotoxicitou. Autoři se zamýšlejí nad možnostmi prevence a léčení PAS.
Despite the great array of observations, the etiopathogenesis of the autism spectrum disorders (ASD) is poorly defined. Our review offers evidence that most heterogeneous symptoms of ASD might have a common set of pathophysiological events at cellular level closely connected with dysregulation of gluta-matergic neurotransmission in the brain with excitotoxicity as a common underlying mechanism. The suggested unifying hypothesis offers the means for efficient prevention and amelioration of ASD.
- MeSH
- autistická porucha MeSH
- centrální nervový systém růst a vývoj účinky záření MeSH
- epilepsie etiologie patofyziologie MeSH
- financování organizované MeSH
- fluoridy toxicita MeSH
- glutamáty fyziologie metabolismus škodlivé účinky MeSH
- hliník toxicita MeSH
- kyselina aspartová fyziologie metabolismus škodlivé účinky MeSH
- neurotransmiterové látky fyziologie metabolismus MeSH
- receptory N-methyl-D-aspartátu fyziologie MeSH
- zpožděný efekt prenatální expozice MeSH
- Publikační typ
- přehledy MeSH
Increasing infertility, due to pathological changes on sperm, has become a serious issue. Eco-toxicological effect of rising concentration of fluorides can be enhanced in the presence of aluminium ions by forming fluorometallic complexes, analogues of phosphate groups that interfere with the activity of G-proteins and P-type ATPases, which are part of several signalling pathways during sperm maturation. In order for sperm to gain fertilizing ability, they must undergo in the female reproductive tract, capacitation that includes tyrosine phosphorylation and consequent actin polymerization. The present paper reports the findings of 3-month oral toxicity in mice of fluorides at the concentrations 0, 1, 10, and 100ppm and their synergic action with aluminium at dose of 10ppm. There were no mortalities, clinical signs of discomfort or body weight loss during the experiment. The analysis revealed, for the concentrations of 10 and 100ppm, abnormalities of spermatogenesis and ability of epididymal spermatozoa to capacitate in vitro, as the result of decreased sperm head tyrosine phosphorylation and actin polymerization. The enhancing overload caused by fluorides represents a potential factor, having an impact on function of sperm, hence contributing to a growing infertility in the human population.
- MeSH
- financování organizované MeSH
- fluoridy toxicita MeSH
- hliník toxicita MeSH
- kapacitace spermií účinky léků MeSH
- látky znečišťující vzduch toxicita MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- spermie účinky léků MeSH
- testis patologie účinky léků MeSH
- velikost orgánu účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- MeSH
- chemické látky znečišťující vodu analýza chemie škodlivé účinky MeSH
- chronické poškození mozku chemicky indukované krev patologie MeSH
- fluoridace dějiny škodlivé účinky trendy MeSH
- fluoridy krev škodlivé účinky toxicita MeSH
- lidé MeSH
- minerální vody analýza škodlivé účinky MeSH
- Check Tag
- lidé MeSH
