Mature Wistar rats were exposed to intermittent hypobaric hypoxia (5000 m, 6 h/day, 30 sessions). This mode of adaptation enhanced heart tolerance to the arrhythmogenic action of 45-min coronary occlusion, but does not affect the infarction size/risk area ratio. In some series, the rats were exposed to more severe intermittent hypobaric hypoxia (7000 m, 8 h/day, 6 weeks) followed by 20-min coronary occlusion and 3-h reperfusion one day after the last hypoxia session. In this case, adaptation reduced the infarction size/risk area ratio and enhanced cardiac tolerance to the arrhythmogenic effect of reperfusion, but had no effect on the incidence of ventricular arrhythmia during ischemia. We found that the cardioprotective and antiarrhythmic effects of adaptation to an altitude of 7000 m and the antiarrhythmic effect of 5000-m adaptation were mediated via activation of K(ATP) channels.
- MeSH
- atmosférický tlak MeSH
- cytoprotekce fyziologie účinky léků MeSH
- fyziologická adaptace fyziologie účinky léků MeSH
- hypoxie patologie prevence a kontrola MeSH
- imidazoly farmakologie MeSH
- ischemické přivykání metody veterinární MeSH
- KATP kanály agonisté fyziologie MeSH
- krysa rodu rattus MeSH
- myokard patologie MeSH
- nadmořská výška MeSH
- potkani Wistar MeSH
- srdeční arytmie prevence a kontrola MeSH
- thioamidy farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
- Publikační typ
- hodnotící studie MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
