CRISPR is a prokaryotic defence system that was adapted as a tool for genome editing and has become one of the most important discoveries of this century. CRISPR-associated endonucleases cleave DNA at precise sites, which are marked by complementary short-guided RNA. The recently developed versions of endonucleases are compatible with a broad range of PAM motifs, have a higher specificity and enable a specific nucleotide to be replaced.

• MeSH
• DNA genetika   MeSH
• editace genu * MeSH
• endonukleasy genetika   metabolismus   MeSH
• guide RNA, Kinetoplastida genetika   MeSH
• lidé MeSH
• sekvence CRISPR genetika   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH