JavaScript NENÍ povolen !

"K23 MH101380" Dotaz Zobrazit nápovědu

1 záznamů v Medvik

Článek

Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

Huggins, Ashley A
Autor Huggins, Ashley A ORCID Brain Imaging and Analysis Center, Duke University, Durham, NC, USA. aahuggins@arizona.edu Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA. aahuggins@arizona.edu
Baird, C Lexi
Autor Baird, C Lexi ORCID Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
Briggs, Melvin
Autor Briggs, Melvin Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
Laskowitz, Sarah
Autor Laskowitz, Sarah Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
Hussain, Ahmed
Autor Hussain, Ahmed ORCID Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
Fouda, Samar
Autor Fouda, Samar Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA Department of Psychiatry & Behavioral Sciences, Duke School of Medicine, Durham, NC, USA
Haswell, Courtney
Autor Haswell, Courtney Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
Sun, Delin
Autor Sun, Delin Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA Department of Psychology, The Education University of Hong Kong, Ting Kok, Hong Kong
Salminen, Lauren E
Autor Salminen, Lauren E Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
Jahanshad, Neda
Autor Jahanshad, Neda Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA

Molecular psychiatry. 2024 ; 29 (3) : 611-623. [pub] 20240110

Mol Psychiatry
ISSN 1476-5578
Medvik
Zdroj

Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p-FDR < 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status. These findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in higher-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD.

MeSH
bílá hmota patologie diagnostické zobrazování MeSH
deep learning MeSH
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
magnetická rezonanční tomografie * metody MeSH
mozeček * patologie diagnostické zobrazování MeSH
posttraumatická stresová porucha * patologie patofyziologie diagnostické zobrazování MeSH
šedá hmota patologie MeSH
velikost orgánu MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
metaanalýza MeSH

Kolekce

Publikováno

Filtry

"K23 MH101380" Dotaz Zobrazit nápovědu

"K23 MH101380" Dotaz Zobrazit nápovědu

Upřesnit dle MeSH