Iron(II) affinity
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Ten-eleven translocation protein (TET) 1 plays a key role in control of DNA demethylation and thereby of gene expression. Dysregulation of these processes leads to serious pathological states such as oncological and neurodegenerative ones and thus TET 1 targeting is highly requested. Therefore, in this work, we examined the ability of hydrazones (acyl-, aroyl- and heterocyclic hydrazones) to inhibit the TET 1 protein and its mechanism of action. Inhibitory activity of hydrazones 1-7 towards TET 1 was measured. The results showed a high affinity of the tested chelators for iron(II). The study clearly showed a significant correlation between the chelator's affinity for iron(II) ions (represented by the binding constant) and TET 1 protein inhibitory activity (represented by IC50 values).
- MeSH
- chelátory železa chemická syntéza chemie toxicita MeSH
- dioxygenasy antagonisté a inhibitory chemie MeSH
- enzymatické testy MeSH
- epigeneze genetická účinky léků MeSH
- hydrazony chemická syntéza chemie toxicita MeSH
- inhibitory enzymů chemická syntéza chemie toxicita MeSH
- železo chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
... the Major Classes of Antibodies in Humans 1318 -- TABLE 24-3 Properties of Human Class I and Class II ... ... Sequence 307 -- Transcription Initiation in Eukaryotes Requires Many Proteins 309 -- RNA Polymerase II ... ... Functions 447 Proteins Can Be Separated by Chromatography 448 -- Immunoprecipitation Is a Rapid Affinity ... ... be-r Complex Connects Photosystem II to •stem I -- Carries Out the Second Charge-Separation \" *ne Z ... ... -- Myosin Generates Force by Coupling ATP Hydrolysis to Conformational Changes -- Sliding of Myosin II ...
Sixth edition xxxiv, 1430 stran v různém stránkování : ilustrace (převážně barevné) ; 29 cm
- Konspekt
- Biochemie. Molekulární biologie. Biofyzika
- NLK Obory
- molekulární biologie, molekulární medicína
- NLK Publikační typ
- učebnice vysokých škol
Bulged DNA structures are of general biological significance because of their important roles in a number of biochemical processes. Compounds capable of targeting bulged DNA sequences can be used as probes for studying their role in nucleic acid function, or could even have significant therapeutic potential. The interaction of [Fe(2)L(3)](4+) metallosupramolecular helicates (L = C(25)H(20)N(4)) with DNA duplexes containing bulges has been studied by measurement of the DNA melting temperature and gel electrophoresis. This study was aimed at exploring binding affinities of the helicates for DNA bulges of various sizes and nucleotide sequences. The studies reported herein reveal that both enantiomers of [Fe(2)L(3)](4+) bind to DNA bulges containing at least two unpaired nucleotides. In addition, these helicates show considerably enhanced affinity for duplexes containing unpaired pyrimidines in the bulge and/or pyrimidines flanking the bulge on both sides. We suggest that the bulge creates the structural motif, such as the triangular prismatic pocket formed by the unpaired bulge bases, to accommodate the [Fe(2)L(3)](4+) helicate molecule, and is probably responsible for the affinity for duplexes with a varying number of bulge bases. Our results reveal that DNA bulges represent another example of unusual DNA structures recognized by dinuclear iron(II) ([Fe(2)L(3)](4+)) supramolecular helicates.
... Ubiquitin Marks Cytosolic Proteins for Degradation in Proteasomes 88 -- I Regulating Protein Function II ... ... Charge-to-Mass Ratio 94 -- Liquid Chromatography Resolves Proteins by -- Mass, Charge, or Binding Affinity ... ... Has an -- Essential Carboxyl-Terminal Repeat 279 -- RNA Polymerase II Initiates Transcription at DNA ... ... Regulate -- Eukaryotic Genes 282 -- Distant Enhancers Often Stimulate Transcription by RNA Polymerase II ... ... 15.1 The infancy of signal Transduction—GTP Stimulation of cAMP Synthesis 663 -- 16 CELL-SIGNALING II ...
6th ed. xxxvii, 1150 s. : il., tab. ; 29 cm
- MeSH
- biologie buňky MeSH
- molekulární biologie MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Biochemie. Molekulární biologie. Biofyzika
- NLK Obory
- biologie
- cytologie, klinická cytologie
... Evans -- PART II -- IMMUNOLOGIC BASIS OF HEMATOLOGY 107 -- Chapter 10 -- Overview and Compartmentalization ... ... Chapter 31 -- Pathology of Iron Metabolism 473 -- Nancy C. ... ... Andrews -- Chapter 32 -- Disorders of Iron Metabolism: Iron Deficiency and Overload 481 -- Gary M. ... ... Embury -- Chapter 38 -- Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity ... ... White, II, and J. Evan Sadler Chapter 122 -- Vitamin K: Metabolism and Disorders 2136 -- Barbara C. ...
Fourth edition xxix, 2821 stran : ilustrace, tabulky + 1 CD-ROM ; 28 cm
- MeSH
- hematologie MeSH
- krev - fyziologické jevy MeSH
- krevní nemoci MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- hematologie a transfuzní lékařství
... 295 -- Chapter 12 Lipids and Cell Membranes 319 -- Chapter 13 Membrane Channels and Pumps 345 -- PART II ... ... Purified 79 -- 44.3 Proteins Can Be Purified According to -- Solubility, Stee, Charge, and Binding Affinity ... ... Is Assembled Only Within Complexes of Cognate DNA Molecules, Ensuring Specificity 248 -- 9.3.4 Type II ... ... - 13.6 Gap Junctions Allow Ions and Small Molecules to Flow Between Communicating Cells 363 -- PART II ... ... /Links Photosystem II to -- Photosystem I 536 -- 19.3.3 Photosystem I Uses Light Energy to Generate - ...
5th ed. xvii, 974 s. : il., tab., grafy ; 32 cm
... Dang -- PART II -- Immunologic Basis of Hematology 73 -- Chapter 7 -- Overview of the Immune System ( ... ... Spivak -- Chapter 26 -- Disorders of Iron Metabolism: Iron Deficiency and Overload 397 -- Gary M. ... ... Vichinsky -- Chapter 31 -- Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity ... ... White II and Robert R. ...
3rd edition xxxi, 2584 stran, 24 nečíslovaných stran obrazových příloh : ilustrace, tabulky ; 29 cm
- MeSH
- hematologie MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- hematologie a transfuzní lékařství
- NLK Publikační typ
- kolektivní monografie
... Dang -- Part II. Immunology 85 -- 8. ... ... Spivak -- Disorders of Iron and Heme Synthesis -- 38. ... ... Disorders of Iron Metabolism: Iron Deficiency and Overload 492 -- Gary M. Brittenham -- 39. ... ... White II and Robert R. Montgomery -- 114. Vitamin K: Metabolism and Disorders 1737 Barbara C. ... ... Spitalnik -- II. Protein Determinants 1954 Marilyn J. Telen -- 132. ...
Second edition xxvii, 2369 stran, 23 nečíslovaných stran obrazové přílohy : ilustrace, tabulky ; 29 cm
- MeSH
- hematologie MeSH
- krevní nemoci diagnóza terapie MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- hematologie a transfuzní lékařství
... CONTENTS -- COLOR PLATES xxxv -- PART I MEDICINE AS A LEARNED AND HUMANE PROFESSION 1 -- PART II HUMAN ... ... /onsen 12 -- PART II HUMAN GROWTH, DEVELOPMENT, AND AGING -- 6 ADOLESCENT MEDICINE, Iris F. ... ... Pope II -- 99 GASTRITIS, Charles T. ... ... Rieder 942 -- 145 ABNORMAL HEMOGLOBINS WITH ALTERED OXYGEN AFFINITY, Ronald F. ... ... Wyngaarden -- 205 WILSON’S DISEASE, Andrew Deiss -- 206 HEMOCHROMATOSIS (IRON STORAGE DISEASE), Arno ...
18th edit 2404 s. : obr., tab.,přeruš.bibliogr.
... and Alcohol Intoxication -- 305 -- 7.11 Glycogen Storage Diseases 310 -- 8 CARBOHYCRATE METABOLISM II ... ... Overview 356 9.2 The Chemical Nature of Fatty Acids and Acylglycerols 357 12 AMINO ACID METABOLISM II ... ... Awad, Jr. 22.1 Iron Metabolism: Overview 855 22.2 Iron-Containing Proteins 856 22.3 Intestinal Absorption ... ... of Iron 859 22.4 Iron Distribution and Kinetics 861 22.5 Heme Biosynthesis 862 22.6 Heme Catabolism ... ... 868 855 -- CLINICAL CORRELATIONS 22.1 Iron-Deficiency Anemia 861 22.2 Hemochromatosis and Iron-Fortified ...
2nd edit 1016 s. : obr., tab., přeruš.bibliogr.
- Klíčová slova
- biochemie klinická - učebnice vysokoškolské,
- Konspekt
- Biochemie. Molekulární biologie. Biofyzika
- NLK Obory
- biochemie
