PRDX3 Dotaz Zobrazit nápovědu
The most vital factors that hostile health human are toxic heavy metals (THMs). Heavy metals are harmful environmental contaminants that can decrease the likelihood of a healthy pregnancy and afterwards impede a healthy birth. Both paternal and maternal toxic metal exposure could influence pregnancy, So the rates of pregnancy failure are constantly rising. The current study's goal is to explore the effect of Pеrоxirеdоxin 3 antioxidant, as well as some toxic metals (TMs) such as arsenic, cadmium and mercury in missed abortion patients and compared with healthy pregnant and non˗pregnant women without a history of abortion in order to evaluate the degree of this effect on this pathological situation. Additionally, it will demonstrate the connection between these biochemical variables and gestational age. Pеrоxirеdоxin 3 (Prx3), Arsenic (As), Cadmium (Cd), and Mercury (Hg) as a (THMs) were estimated in 40 healthy non˗pregnant (HNP) women, 40 healthy prеgnаnts (HP) with no abortion history, and 20 women with missed abortion (MA). All woman participants are of reproductive age, with the maternal gestational age in the HP and MA groups being ≤ 20 weeks. Maternal gestational age was used to categorize MA and HP women into two groups (1st & 2nd trimester).Regarding to the findings of recent research, Prx3 levels declined noticeably in MA patients compared to HP and HNP groups, on other hand the difference of toxic metals which represented in this study as: (As, Cd, and Hg) elevated statistically significantly in MA patients compared to HP and HNP groups. Within the first and second trimesters of pregnancy, the difference of Prx3 levels showed statistically significant reduction between the MA and HP groups. A statistical significance elevation was found between the two comparable gestational age of both groups in regard to blood serum (As, Cd, and Hg) levels. Lastly, the impact of gestational period within MA cases was revealed, serum (Cd) and (Hg) showing a significant variation between the first and second trimester of pregnancy, whereas Prx3 and (As) were unaffected by pregnancy advances within the MA group.
The pаthоphysiolоgy of recurrent spontaneous abortion (RSA) has been linked to oxidative stress (OS), which is defined as an imbalance between the formation of oxidants and the antioxidant defense system. The goal of this study was to assess the state of OS in recurrent spontaneous abortion by assessing some of its indicators in order to identify women who are at risk of abortion and enhance their reproductive health. Peroxiredoxin 3 (Prx3), progesterone (P4), glutathione (GSH), uric acid (UA), pеrоxynitritе (ONOO-), and mаlоndialdеhyde (MDA) were measured in 40 healthy non-pregnant (HNP) women, 40 healthy pregnant (HP) women without abortion history, and 21 women with recurrent spontaneous abortion (Have at least ≥ 3 consecutive abortion). All subjects are of reproductive age, with the mother gestational age in the HP and RSA groups being ≤ 20 weeks. According to maternal gestational age, RSA and HP women were separated into two categories (1st & 2nd trimester). According to the findings of this study, Prx3 and GSH levels declined considerably in RSA patients compared to HP and HNP patients, but ONOO- and MDA levels increased statistically significantly in RSA patients compared to HP and HNP groups. However, P4 of RSA was found to be significantly lower in the HP group and much higher in the HNP group. The difference in uric acid levels between the RSA and HP groups was statistically significant, but the difference between the RSA and HNP groups was not.Within the first and second trimesters of pregnancy, the difference between the RSA and HP groups showed statistically significant changes in oxidative stress-related biomarkers, with the exception of uric acid, which showed a non-significant difference between the two groups within the second trimester.Finally, the effect of gestational age within RSA was revealed, with serum Prx3 and P4 showing a significant difference between the first and second stages of pregnancy, whereas other oxidative stress indicators were unaffected by pregnancy length within the RSA group.
- MeSH
- antioxidancia analýza MeSH
- biochemická analýza krve metody MeSH
- habituální potrat * krev MeSH
- lidé MeSH
- oxidační stres MeSH
- oxidancia krev MeSH
- peroxiredoxin III * krev MeSH
- statistika jako téma MeSH
- těhotenství krev MeSH
- Check Tag
- lidé MeSH
- těhotenství krev MeSH
- ženské pohlaví MeSH
- Publikační typ
- klinická studie MeSH
- Geografické názvy
- Irák MeSH
