- Klíčová slova
- XANIDIL, ISKEDYL,
- MeSH
- kochlea krevní zásobení MeSH
- morčata MeSH
- stria vascularis účinky léků MeSH
- vazodilatancia farmakologie MeSH
- zvířata MeSH
- Check Tag
- morčata MeSH
- zvířata MeSH
Many investigations on surgical methods and medical treatment are currently done on pigs. This is possible because the pig is sufficiently close genetically to humans. In recent years, progress in liver surgery has opened new possibilities in surgical treatment of liver diseases. Because the methods are relatively novel, various improvements are still needed, and it is thus helpful to conduct experimental surgeries on pig livers. We reviewed the literature to compare the anatomic and functional features of pig and human livers, information that will be of great importance for improving surgical techniques. During the literature review, we used various sources, such as PubMed, Scopus, and veterinary journals. Our results were summarized in diagrams to facilitate understanding of the vascular structure and biliary systems. We conclude that, although the shapes of the human and pig livers are quite different, the pig liver is divided into the same number of segments as the human liver, which also shows a common structure of the vascular system. Thus, with the anatomic and structural features of the pig liver taken into account, this animal model can be used in experimental hepatic surgery.
- MeSH
- arteria hepatica anatomie a histologie chirurgie MeSH
- druhová specificita MeSH
- hepatektomie metody MeSH
- játra krevní zásobení chirurgie MeSH
- katetrizační ablace metody MeSH
- lidé MeSH
- modely u zvířat MeSH
- Sus scrofa MeSH
- terapeutická embolizace metody MeSH
- transplantace jater metody MeSH
- věkové faktory MeSH
- velikost orgánu MeSH
- vena portae anatomie a histologie chirurgie MeSH
- venae hepaticae anatomie a histologie chirurgie MeSH
- žlučové cesty anatomie a histologie chirurgie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
A study of new pig manure treatment and filtration process was carried out. The advantage of the worked out technology is the method of incorporation of crystalline phase into solid organic part of manure. The obtained new solid phase of manure contains about 50% of crystalline phase forming a filtration aid that enables high effectiveness of manure filtration. The filtration rate of manure separation into solid and liquid fractions with pressure filter may achieve 1300-3000 kg/m(2)/h. The method makes it possible to maintain an overall average pollutant removal performance 90% for the chemical oxygen demand COD, > 99% for the suspended solids SS, to 47% for the total nitrogen content. The obtained results showed that the proposed technology being efficient and simple offers a possible solution to pig manure problems.
- MeSH
- anaerobióza MeSH
- filtrace * MeSH
- hnůj * MeSH
- prasata MeSH
- průmyslová hnojiva * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Oxidative phosphorylation is a key process of intracellular energy transfer by which mitochondria produce ATP. Isolated mitochondria serve as a biological model for understanding the mitochondrial respiration control, effects of various biologically active substances, and pathophysiology of mitochondrial diseases. The aim of our study was to evaluate pig brain mitochondria as a proper biological model for investigation of activity of the mitochondrial electron transport chain. Oxygen consumption rates of isolated pig brain mitochondria were measured using high-resolution respirometry. Mitochondrial respiration of crude mitochondrial fraction, mitochondria purified in sucrose gradient, and mitochondria purified in Percoll gradient were assayed as a function of storage time. Oxygen flux and various mitochondrial respiratory control ratios were not changed within two days of mitochondria storage on ice. Leak respiration was found higher and Complex I-linked respiration lower in purified mitochondria compared to the crude mitochondrial fraction. Damage to both outer and inner mitochondrial membrane caused by the isolation procedure was the greatest after purification in a sucrose gradient. We confirmed that pig brain mitochondria can serve as a biological model for investigation of mitochondrial respiration. The advantage of this biological model is the stability of respiratory parameters for more than 48 h and the possibility to isolate large amounts of mitochondria from specific brain areas without the need to kill laboratory animals. We suggest the use of high-resolution respirometry of pig brain mitochondria for research of the neuroprotective effects and/or mitochondrial toxicity of new medical drugs.
- MeSH
- biologické modely * MeSH
- buněčné dýchání MeSH
- citrátsynthasa metabolismus MeSH
- kyslík metabolismus MeSH
- mitochondriální membrány metabolismus MeSH
- mitochondrie metabolismus MeSH
- mozek metabolismus MeSH
- Sus scrofa MeSH
- transport elektronů MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- Candida patogenita MeSH
- mikrobiologické techniky MeSH
- morčata MeSH
- nemoci rohovky MeSH
- Check Tag
- morčata MeSH
