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Autor
Allegri, Landino 1 Amore, Alessandro 1 Amoroso, Antonio 1 Appel, Gerald 1 Barlassina, Cristina 1 Barratt, Jonathan 1 Battaglia, Giovanni Giorgio 1 Berthoux, Francois 1 Bertinetto, Francesca Eleonora 1 Bodria, Monica 1 Boer, Emanuela 1 Boland, Anne 1 Boscutti, Giuliano 1 Caliskan, Yasar 1 Canaud, Guillaume 1 Caridi, Gianluca 1 Chen, Nan 1 Chicca, Silvana 1 Choi, Murim 1 Coppo, Rosanna 1
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Pracoviště
3 Medizinische Klinik Universitätskli... 1 Centre National de Génotypage Commiss... 1 Chair of Nephrology Division of Nepho... 1 Department of Immunology Transplantol... 1 Department of Medical and Surgical Sc... 1 Department of Medicine University of ... 1 Department of Microbiology University... 1 Department of Nephrology 1st Faculty ... 1 Department of Nephrology 2nd Universi... 1 Department of Nephrology Dialysis and... 1 Department of Nephrology RWTH Univers... 1 Department of Nephrology Ruijin Hospi... 1 Department of Nephrology Transplantol... 1 Department of Nephrology and Dialysis... 1 Department of Pediatrics and Nephrolo... 1 Division of Clinical Nephrology and R... 1 Division of Nephrology Azienda Ospeda... 1 Division of Nephrology Azienda Ospeda... 1 Division of Nephrology Cannizzaro Hos... 1 Division of Nephrology Department of ... 1
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Autor
Allegri, Landino 1 Amore, Alessandro 1 Amoroso, Antonio 1 Appel, Gerald 1 Barlassina, Cristina 1 Barratt, Jonathan 1 Battaglia, Giovanni Giorgio 1 Berthoux, Francois 1 Bertinetto, Francesca Eleonora 1 Bodria, Monica 1 Boer, Emanuela 1 Boland, Anne 1 Boscutti, Giuliano 1 Caliskan, Yasar 1 Canaud, Guillaume 1 Caridi, Gianluca 1 Chen, Nan 1 Chicca, Silvana 1 Choi, Murim 1 Coppo, Rosanna 1
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Pracoviště
3 Medizinische Klinik Universitätskli... 1 Centre National de Génotypage Commiss... 1 Chair of Nephrology Division of Nepho... 1 Department of Immunology Transplantol... 1 Department of Medical and Surgical Sc... 1 Department of Medicine University of ... 1 Department of Microbiology University... 1 Department of Nephrology 1st Faculty ... 1 Department of Nephrology 2nd Universi... 1 Department of Nephrology Dialysis and... 1 Department of Nephrology RWTH Univers... 1 Department of Nephrology Ruijin Hospi... 1 Department of Nephrology Transplantol... 1 Department of Nephrology and Dialysis... 1 Department of Pediatrics and Nephrolo... 1 Division of Clinical Nephrology and R... 1 Division of Nephrology Azienda Ospeda... 1 Division of Nephrology Azienda Ospeda... 1 Division of Nephrology Cannizzaro Hos... 1 Division of Nephrology Department of ... 1
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Prakash, Sindhuri* Dotaz Zobrazit nápovědu
Medline Complete (EBSCOhost) od 1998-06-01 do 2015-11-30
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 2000-01-01 do Před 1 rokem
PubMed
25305756
DOI
10.1038/ng.3118
Knihovny.cz E-zdroje
We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geospatial distribution of risk alleles is highly suggestive of multi-locus adaptation, and genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN.
- MeSH
- antigeny CD11b genetika MeSH
- celogenomová asociační studie MeSH
- genetická pleiotropie genetika MeSH
- genetické lokusy genetika MeSH
- HLA-D antigeny genetika MeSH
- IgA nefropatie genetika MeSH
- imunita genetika MeSH
- interakce hostitele a patogenu genetika MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé MeSH
- protoonkogenní proteiny c-vav genetika MeSH
- signální adaptorové proteiny CARD genetika MeSH
- střeva imunologie parazitologie MeSH
- věk při počátku nemoci MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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