In the evolving landscape of cardiac rehabilitation (CR), adopting digital technologies, including synchronous/real-time digital interventions and smart applications, has emerged as a transformative approach. These technologies offer real-time health data access, continuous vital sign monitoring, and personalized educational enhanced patient self-management and engagement. Despite their potential benefits, challenges and limitations exist, necessitating careful consideration. Synchronous/real-time digital CR involves remote, two-way audiovisual communication, addressing issues of accessibility and promoting home-based interventions. Smart applications extend beyond traditional healthcare, providing real-time health data and fostering patient empowerment. Wearable devices and mobile apps enable continuous monitoring, tracking of rehabilitation outcomes, and facilitate lifestyle modifications crucial for cardiac health maintenance. As digital CR progresses, ensuring patient access, equitable implementation, and addressing the digital divide becomes paramount. Artificial intelligence holds promise in the early detection of cardiac events and tailoring patient-specific CR programs. However, challenges such as digital literacy, data privacy, and security must be addressed to ensure inclusive implementation. Moreover, the shift toward digital CR raises concerns about cost, safety, and potential depersonalization of therapeutic relationships. A transformative shift towards technologically enabled CR necessitates further research, focusing not only on technological advancements but also on customization to meet diverse patient needs. Overcoming challenges related to cost, safety, data security, and potential depersonalization is crucial for the widespread adoption of digital CR. Future studies should explore integrating moral values into digital therapeutic relationships and ensure that digital CR is accessible, equitable, and seamlessly integrated into routine cardiac care. Theoretical frameworks that accommodate the dynamic quality of real-time monitoring and feedback feature of digital CR interventions should be considered to guide intervention development.

• Publikační typ
• úvodníky MeSH

Neoadjuvantní systémová farmakoterapie má potenciál konvertovat iniciálně neresekabilní metastázy do resekabilního stavu. Přesná kritéria pro výběr nemocných, optimální režim farmakoterapie, trvání neoadjuvantní terapie včetně načasování chirurgické intervence závisí na řadě faktorů jak ze strany nemocného (PS, přidružená onemocnění), tak ze strany choroby (rozsah a lokalizace metastáz, synchronní vs metachronní postižení). Skutečná frekvence konverzí je pravděpodobně nízká. Klíčová slova: kolorektální karcinom – jaterní metastázy – léčba – konverze

Neoadjuvant systemic pharmacotherapy has the potential to convert initially unresectable metastases to resectable ones. The exact criteria for patient selection, optimum therapeutic regime and duration of neoadjuvant therapy, including the timing of surgical intervention, depend on many factors related to the patient (performance status, co-morbidities, etc.) and to the disease (extent and localization of metastases, synchronous vs metachronous form, etc.). The real conversion rate is likely to be low. Key words: colorectal cancer – liver metastases – treatment – conversion The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers. Submitted: 29. 8. 2014 Accepted: 2. 10. 2014

• Klíčová slova
• konverzní léčba,
• MeSH
• adjuvantní chemoterapie MeSH
• indukční chemoterapie * metody   MeSH
• kolorektální nádory * MeSH
• lidé MeSH
• nádory jater * farmakoterapie   chirurgie   sekundární   MeSH
• neoadjuvantní terapie MeSH
• protokoly protinádorové kombinované chemoterapie škodlivé účinky   terapeutické užití   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• práce podpořená grantem MeSH
• přehledy MeSH