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Autor
Addison, Owen 1 Al-Jamal, Khuloud 1 Bergholt, Mads 1 Birjandi, Anahid Ahmadi 1 Brauer, Delia S 1 Caprettini, Valeria 1 Chiappini, Ciro 1 Clarke, Paul 1 Gentleman, Eileen 1 Hondow, Nicole 1 Isaacs, Mark 1 Kaasalainen, Martti 1 Martella, Davide Alessandro 1 Moldenhauer, Evelin 1 Morrell, Alexander P 1 Mustfa, Salman A 1 Mäkilä, Ermei 1 Pinna, Alessandra 1 S'Ari, Mark 1 Salonen, Jarno 1
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Pracoviště
Centre for Craniofacial and Regenerat... 1 Centre for Oral Clinical and Translat... 1 Department of Chemistry University Co... 1 Department of Dental Materials and NM... 1 Department of Materials Imperial Coll... 1 Department of Oral Pathology Peking U... 1 Department of Physics and Astronomy U... 1 HarwellXPS Research Complex at Harwel... 1 Institute of Animal Physiology and Ge... 1 Institute of Pharmaceutical Science K... 1 London Centre for Nanotechnology King... 1 Otto Schott Institute of Materials Re... 1 Postnova Analytics GmbH Rankinestr 1 ... 1 School of Chemical and Process Engine... 1 School of Veterinary Medicine Faculty... 1 The Francis Crick Institute London NW... 1
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Autor
Addison, Owen 1 Al-Jamal, Khuloud 1 Bergholt, Mads 1 Birjandi, Anahid Ahmadi 1 Brauer, Delia S 1 Caprettini, Valeria 1 Chiappini, Ciro 1 Clarke, Paul 1 Gentleman, Eileen 1 Hondow, Nicole 1 Isaacs, Mark 1 Kaasalainen, Martti 1 Martella, Davide Alessandro 1 Moldenhauer, Evelin 1 Morrell, Alexander P 1 Mustfa, Salman A 1 Mäkilä, Ermei 1 Pinna, Alessandra 1 S'Ari, Mark 1 Salonen, Jarno 1
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Pracoviště
Centre for Craniofacial and Regenerat... 1 Centre for Oral Clinical and Translat... 1 Department of Chemistry University Co... 1 Department of Dental Materials and NM... 1 Department of Materials Imperial Coll... 1 Department of Oral Pathology Peking U... 1 Department of Physics and Astronomy U... 1 HarwellXPS Research Complex at Harwel... 1 Institute of Animal Physiology and Ge... 1 Institute of Pharmaceutical Science K... 1 London Centre for Nanotechnology King... 1 Otto Schott Institute of Materials Re... 1 Postnova Analytics GmbH Rankinestr 1 ... 1 School of Chemical and Process Engine... 1 School of Veterinary Medicine Faculty... 1 The Francis Crick Institute London NW... 1
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Vashisth, Priya* Dotaz Zobrazit nápovědu
Free Medical Journals od 2010
Nature Open Access od 2010-12-01
PubMed Central od 2012
Europe PubMed Central od 2012
ProQuest Central od 2010-01-01
Open Access Digital Library od 2015-01-01
Open Access Digital Library od 2015-01-01
Medline Complete (EBSCOhost) od 2012-11-01
Health & Medicine (ProQuest) od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources od 2010
PubMed
38216556
DOI
10.1038/s41467-023-44581-5
Knihovny.cz E-zdroje
Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.
- MeSH
- beta-katenin * MeSH
- křemík farmakologie MeSH
- kyselina křemičitá farmakologie MeSH
- lithium farmakologie MeSH
- myši MeSH
- nanodráty * MeSH
- poréznost MeSH
- zubní cement (tkáň) MeSH
- zvířata MeSH
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- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
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