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Abdile, Ahmed 1 Adamina, Michel 1 Aigner, Felix 1 Allmer, Caterina 1 Andric, Mihailo 1 Anula, Rocio 1 Atallah, Sam 1 Bach, Simon 1 Bala, Miklosh 1 Barussaud, Marie 1 Bausys, Augustinas 1 Bebington, Brendan 1 Beggs, Andrew 1 Bellolio, Felipe 1 Bennett, Melissa-Rose 1 Berdinskikh, Anton 1 Bevan, Vicki 1 Biondo, Sebastiano 1 Bislenghi, Gabriele 1 Bludau, Marc 1
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4th Coloproctology Department St Pete... 1 Advent Health Colorectal Surgery Orla... 1 AdventHealth Medical Group Colorectal... 1 Cambridge Colorectal Unit Addenbrooke... 1 Centre for Colorectal Disease St Vinc... 1 Colorectal Surgery Department British... 1 Colorectal Surgery Division Angelita ... 1 Colorectal Surgery Unit General Surge... 1 Colorectal Surgical Oncology Abdomina... 1 Department for Hereditary Tumors Evan... 1 Department of Biomedical Sciences Hum... 1 Department of Clinical Pathology the ... 1 Department of Colorectal Surgery Adve... 1 Department of Colorectal Surgery Clín... 1 Department of Colorectal Surgery Hosp... 1 Department of Colorectal Surgery Nati... 1 Department of Digestive Surgery Facul... 1 Department of Gastroenterology Univer... 1 Department of Medical Oncology Bank o... 1 Department of Oncology Oslo Universit... 1
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Autor
Abdile, Ahmed 1 Adamina, Michel 1 Aigner, Felix 1 Allmer, Caterina 1 Andric, Mihailo 1 Anula, Rocio 1 Atallah, Sam 1 Bach, Simon 1 Bala, Miklosh 1 Barussaud, Marie 1 Bausys, Augustinas 1 Bebington, Brendan 1 Beggs, Andrew 1 Bellolio, Felipe 1 Bennett, Melissa-Rose 1 Berdinskikh, Anton 1 Bevan, Vicki 1 Biondo, Sebastiano 1 Bislenghi, Gabriele 1 Bludau, Marc 1
- Organizace
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Pracoviště
4th Coloproctology Department St Pete... 1 Advent Health Colorectal Surgery Orla... 1 AdventHealth Medical Group Colorectal... 1 Cambridge Colorectal Unit Addenbrooke... 1 Centre for Colorectal Disease St Vinc... 1 Colorectal Surgery Department British... 1 Colorectal Surgery Division Angelita ... 1 Colorectal Surgery Unit General Surge... 1 Colorectal Surgical Oncology Abdomina... 1 Department for Hereditary Tumors Evan... 1 Department of Biomedical Sciences Hum... 1 Department of Clinical Pathology the ... 1 Department of Colorectal Surgery Adve... 1 Department of Colorectal Surgery Clín... 1 Department of Colorectal Surgery Hosp... 1 Department of Colorectal Surgery Nati... 1 Department of Digestive Surgery Facul... 1 Department of Gastroenterology Univer... 1 Department of Medical Oncology Bank o... 1 Department of Oncology Oslo Universit... 1
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Zaborowski, Alexandra M* Dotaz Zobrazit nápovědu
PubMed
34190968
DOI
10.1001/jamasurg.2021.2380
Knihovny.cz E-zdroje
Importance: The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer. Observations: Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts. Conclusions and Relevance: The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.
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