the impaired GABA theory
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Schizophrenia (SZ) is a highly inherited disease that affects ~0.5% of the population. The genetic and environmental factors are involved in its aetiology and they interact with each other. Combination of symptoms is unique to each patient, the disease seriously interferes with the ability to function in society and affects the mental state of the patient. In most patients, the first manifestations of SZ appear during the adolescence or early adulthood. The hypothesis that SZ origin in impaired development of the nervous system is currently widely accepted. Some studies have identified several genetic and environmental factors that increase the risk of the disease manifestation, but none of them can be considered as the only cause of SZ. The genetics of the disease is complex and in last two decades it is assumed that the cryptic rearrangements could be one of its causes. Cryptic rearrangements (microdeletions and microduplications) are the chromosomal rearrangements smaller than 3-5 Mb. Their discovery was conditioned by the development of molecular genetic and molecular cytogenetic techniques. The aberrations affect one or more genes and change the gene dose. In this article, we present the rearrangements of the regions of human chromosomes more closely associated with the onset and development of SZ. Next, the candidate genes will be presented together with their inclusion in the context of theories trying to explain the origin of SZ through some important factors (e.g. action of dopamine or glutamate or GABA, formation of dendrites and neuronal synapses, etc.).
... the -- Psychosocial Sciences 93 -- 2.1 Jean Piaget and Cognitive Development 93 -- 2.2 Attachment Theory ... ... 97 -- 2.3 Learning Theory 101 -- 2.4 Biology of Memory 110 -- 2.5 Normality and Mental Health 123 -- ... ... Sociobiology and Ethology 131 -- 3.2 Transcultural Psychiatry 139 -- 3.3 Culture-Bound Syndromes 145 -- 4 Theories ... ... Neurocognitive and Other Disorders -- Due to a General Medical Condition 723 -- 21.6 Mild Cognitive Impairment ... ... 29.8 Barbiturates and Similarly Acting -- Drugs 944 -- 29.9 Benzodiazepines and Drugs -- Acting on GABA ...
11th edition xvi, 1472 s. : il., tab. ; 27 cm
- MeSH
- behaviorální vědy MeSH
- duševní poruchy diagnóza farmakoterapie klasifikace terapie MeSH
- psychiatrie MeSH
- psychotropní léky MeSH
- somatické terapie v psychiatrii MeSH
- Konspekt
- Psychiatrie
- NLK Obory
- psychiatrie
- NLK Publikační typ
- kolektivní monografie
... Channels That Conduct Sodium and Potassium 212 -- Inhibitory Synaptic Action Is Usually Mediated by GABA ... ... - and Glycine-Gated Channels That Conduct Chloride 214 -- Currents Through Single GABA- and Glycine-Gated ... ... 217 -- Synaptic Receptors for Glutamate, GABA, and Glycine Are Transmembrane Proteins 219 -- GABA and ... ... of Firing of Thalamic Neurons 897 -- Damage to Either Branch of the Ascending Arousal System May Impair ... ... Emotion Prepare the Body for Action and Communicate Our Emotional States to Other People 983 -- A Theory ...
4th ed. xxxiii, 1414 s. : il., tab., grafy ; 30 cm
- MeSH
- chování MeSH
- molekulární biologie MeSH
- nemoci nervového systému MeSH
- nervový systém MeSH
- neurochemie MeSH
- neurofyziologie MeSH
- neurony MeSH
- neurovědy MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Fyziologie člověka a srovnávací fyziologie
- NLK Obory
- neurovědy
- biologie
