Background: Cardiotrophin-1 is newly discovered chemokin with a lot of functions. Aim of our work was to describemost important of them.Methods: systematically scan of available scientifi c resources.Results: Cardiotrophin-1 stimulates the proliferation of cardiomyocytes. Cardiotrophin-1 expression and plasmavalues are elevated in individuals with heart failure and have high diagnostic effi cacy for the heart failure. Plasma valuesare also an independent prognostic factor. Preliminary fi ndings suggest that the determination of plasma cardiotrophin-1may be useful for the follow-up of hypertensive heart disease in routine clinical practice. Cardiotrophin-1 also plays animportant cardioprotective eff ect on myocardial damage, is a potent regulator of signaling in adipocytes in vitro andin vivo and potentiates the elevation the acute-phase proteins. Cardiotrophin-1 may play also an important protectiverole in other organ systems (such as hematopoietic, neuronal, developmental).Conclusion: Cardiotrophin is a newly discovered chemokin with a lot of system eff ects and is stable in systemcirculation hence permitting its development in the routine clinical investigation.

• MeSH
• akutní koronární syndrom diagnóza   MeSH
• biologické markery krev   metabolismus   MeSH
• chemokiny diagnostické užití   terapeutické užití   MeSH
• cytokiny diagnostické užití   terapeutické užití   MeSH
• ELISA metody   využití   MeSH
• kardiomyocyty metabolismus   účinky léků   MeSH
• kardiovaskulární nemoci diagnóza   MeSH
• krevní nemoci diagnóza   MeSH
• lidé MeSH
• medicína založená na důkazech MeSH
• metabolický syndrom diagnóza   MeSH
• nádory diagnóza   MeSH
• nemoci jater diagnóza   MeSH
• nemoci nervového systému diagnóza   MeSH
• plicní nemoci diagnóza   MeSH
• srdeční selhání diagnóza   MeSH
• zánět diagnóza   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• přehledy MeSH