The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that LpWJL sustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor-1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from LpWJL, as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for LpWJL-mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting.
- MeSH
- acetylmuramyl-alanyl-isoglutamin farmakologie terapeutické užití MeSH
- buněčná stěna chemie MeSH
- epitelové buňky mikrobiologie fyziologie MeSH
- gnotobiologické modely MeSH
- insulinu podobný růstový faktor I metabolismus MeSH
- inzulin metabolismus MeSH
- Lactobacillaceae * fyziologie MeSH
- myši MeSH
- podvýživa * patofyziologie terapie MeSH
- poruchy růstu patofyziologie terapie MeSH
- růst * účinky léků fyziologie MeSH
- signální adaptorový protein Nod2 * metabolismus MeSH
- střeva * mikrobiologie fyziologie MeSH
- střevní mikroflóra * fyziologie MeSH
- střevní sliznice mikrobiologie fyziologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
