- MeSH
- časná diagnóza MeSH
- edém etiologie MeSH
- lidé MeSH
- mukopolysacharidóza VI * diagnóza genetika patologie MeSH
- novorozenec MeSH
- ušní boltec * patologie MeSH
- vrozené deformity končetin diagnostické zobrazování etiologie patologie MeSH
- vývojové onemocnění kostí diagnostické zobrazování etiologie patologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- Publikační typ
- kazuistiky MeSH
- Klíčová slova
- zygotic splitting,
- MeSH
- dvojčata monozygotní MeSH
- fertilizace in vitro metody MeSH
- gravidita MeSH
- incidence MeSH
- lidé MeSH
- přenos embrya metody přístrojové vybavení MeSH
- rozdělení zygoty MeSH
- těhotenství mnohočetné * statistika a číselné údaje MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- lidé MeSH
- nemoci novorozenců MeSH
- novorozenec MeSH
- přechodná tachypnoe novorozence * diagnóza etiologie terapie MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- hemolytická nemoc plodu a novorozence * diagnóza terapie MeSH
- lidé MeSH
- nemoci novorozenců MeSH
- novorozenec MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- konjunktivitida * diagnóza patologie terapie MeSH
- lidé MeSH
- meningitida * diagnóza patologie terapie MeSH
- nekrotizující enterokolitida * diagnóza patologie terapie MeSH
- nemoci novorozenců MeSH
- novorozenec MeSH
- pneumonie * diagnóza patologie terapie MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- Publikační typ
- přehledy MeSH
Background:Screening of neonatal hypoglycemia uses currently intermittent blood sampling. Continuous glucose monitoring (CGM) allows for tighter glucose control and better comfort for newborns and parents. CGM has previously been used in intensive care setting or blinded to clinicians. Our pilot study uses CGM in real time in rooming-in setting. Methods: CGM was attached within first two hours of life. Low glucose readings were verified to prevent overtreatment. Pairs of sensor readings and corresponding blood glucose measurements were assessed retrospectively. Neurodevelopmental evaluation was performed at 24 months. Results: 44 infants were enrolled. Three had verified hypoglycemia found due to CGM. No patient was below 2 standard deviations in any components of Bayley scales. Median scores were: Cognitive 100, language 86, motor 94. Conclusion: Use of CGM in a rooming-in environment is safe from clinical and neurodevelopmental point of view. Randomized trials are needed to evaluate superiority in longer term outcomes.
- MeSH
- diabetes mellitus 1. typu * MeSH
- glukosa terapeutické užití MeSH
- hypoglykemie * diagnóza prevence a kontrola MeSH
- krevní glukóza MeSH
- lidé MeSH
- novorozenec MeSH
- pilotní projekty MeSH
- retrospektivní studie MeSH
- selfmonitoring glykemie MeSH
- studie proveditelnosti MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVE: There are minimal data available on nutrition after early repair of cleft lip and the factors influencing initiation of breastfeeding. This study assessed the impact of the length of surgery, length of ventilation support, and duration of hospital stay on breastfeeding rates after early cleft lip surgery. DESIGN: This is a prospective observational cohort study comparing 2 hospitals providing early surgical repair of facial clefts from January 2014 to December 2016. Both hospitals are designated as Baby-Friendly Hospitals. Demographic and anthropometric data from mothers and newborns were recorded. SETTING: Tertiary neonatal and pediatric surgery center. PATIENTS: Hospital A: 61 newborns, Hospital B: 157 newborns. INTERVENTIONS: Early (day 5 to 14) cheiloplasty in newborns with cleft lip or cleft lip and palate. MAIN OUTCOME MEASURES: Influence of duration of hospital stay, length of operation, and artificial ventilation on the rate of breastfeeding. RESULTS: Significantly, more newborns were breastfed following early surgical repair of an isolated cleft lip compared to those with both cleft lip and palate, in both hospitals (hospital A 82% vs 0%, P = .0001, hospital B 66% vs 5%, P = .0001). Duration of hospital stay, length of operation, and duration of artificial ventilation did not significantly affect the rate of breastfeeding. CONCLUSIONS: The factors associated with early cleft lip repair (length of operation, length of ventilation support, and duration of hospital stay) do not affect breastfeeding rate.
- MeSH
- délka pobytu MeSH
- dítě MeSH
- kojenec MeSH
- kojení MeSH
- lidé MeSH
- novorozenec MeSH
- prospektivní studie MeSH
- rozštěp patra * chirurgie MeSH
- rozštěp rtu * chirurgie MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
Cíl: Cílem studie CERES (CzEch REkovelle real life Study) bylo shromáždit první zkušenosti s užíváním zcela nového gonadotropinu, vyhodnotit účinnost folitropinu delta v běžné české klinické praxi a srovnat získané výsledky s výstupy studie ESTHER-1. Metodika: Ovariální stimulací individualizovanou denní dávkou folitropinu delta v mikrogramech na základě hladiny antimüllerického hormonu (AMH) a tělesné hmotnosti pacientky (AMH < 15 pmol/ l: fixní dávka 12 µg/ d; AMH > 15 pmol/ l: 0,10–0,19 µg/ kg/ d; max. 12 µg/ d). Výsledky: Celkem bylo zařazeno 85 pacientek ve věku 24–42 let, průměrný věk 32,9 let, průměrná tělesná hmotnost 67,8 kg, průměrná hodnota AMH 23,2 pmol/ l. Bylo zahájeno 85 kontrolovaných ovariálních stimulací s folitropinem delta a 84 odběrů vajíček. U 40 pacientek (47 %) byl optimální zisk počtu vajíček (8–14), 75 pacientek (88 %) mělo embryotransfer, 10 (12 %) nemělo embryo vhodné k transferu. U 65 pacientek byl proveden single embryo transfer, u 10 byla transferována dvě embrya. Počet klinických gravidit byl 37 (43,5 % cPR – clinical pregnancy rate), počet porodů živého bylo plodů 30 (35,3 % LBR – live birth rate). Byly hlášeny tři (3,5 %) časné ovariální hyperstimulační syndromy (OHSS) mírného typu. Hospitalizace související s léčbou byla 0. Závěr: Individualizace ovariální stimulace vede k optimalizaci ovariální odpovědi a při zachování účinnosti zvyšuje bezpečnost léčby cestou snížení incidence OHSS. Výsledky získané u české populace jsou zcela srovnatelné s výstupy velké mezinárodní randomizované zaslepené klinické zkoušky ESTHER-1.
Objective: The aim of the study CERES (CzEch REkovelle real life Study) was to gather experience with the use of a novel gonadotrophine, to evaluate the efficacy of follitropin delta in Czech clinical settings and to compare our results with the clinical trial ESTHER-1. Methods: Individualized follitropin delta daily dose in µg based on the patient's anti-Müllerian hormone (AMH) level and body weight (AMH < 15 pmol/ L: 12 µg/ d; AMH > 15 pmol/ L: 0.10–0.19 µg/ kg/ d; max. 2 µg/ d). Results: A total of 85 women (aged 24–42 years) was included in the study. The average patient's age was 32.9 years, the average body weight was 67.8 kg, and the mean level of AMH was 23.2 pmol/ L. There were initiated 85 controlled ovarian stimulations with follitropin delta and 84 egg collections. Forty patients (47%) had optimal number of retrieved eggs (8–14), 75 patients (88%) had embryotransfer, 10 patients (12%) had no embryo suitable for transfer, 65 patients had single embryo transfer and 10 patients had 2 embryos for transfer. There were reported 37 clinical pregnancies (43.5% cPR – clinical pregnancy rate), 30 live births (35.3% LBR – live birth rate), 3 (3.5%) early moderate ovarian hyperstimulation syndroms (OHSS) and no hospitalization due to the treatment. Conclusion: Individualized ovarian stimulation optimizes ovarian response, maintains treatment efficacy and improves safety by reducing OHSS incidence. The results of the Czech population study are fully comparable with the international, randomized, assessor-blinded trial ESTHER-1.
- Klíčová slova
- studie CERES,
- MeSH
- antimülleriánský hormon MeSH
- fertilizace in vitro * MeSH
- folikuly stimulující hormon lidský MeSH
- gonadotropiny MeSH
- individualizovaná medicína MeSH
- indukce ovulace * MeSH
- lidé MeSH
- multicentrické studie jako téma MeSH
- ovariální hyperstimulační syndrom MeSH
- prospektivní studie MeSH
- rekombinantní proteiny MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
OBJECTIVES: To compare palatal growth changes in infants with complete unilateral (UCLP) or bilateral (BCLP) cleft lip and palate during the first year of life. MATERIALS AND METHODS: Upper dental arches of 68 neonates with UCLP and BCLP were evaluated using 2D and 3D morphometry based on dental casts obtained in two age categories (T0 before early neonatal cheiloplasty-UCLP 4 ± 3 days, BCLP 6 ± 5 days; T1 before palatoplasty-UCLP 10 ± 2 months, BCLP 12 ± 3 months). RESULTS: Intensive palatal growth was manifested in both directions of the palate. Palatal growth in the anterior direction was not restricted, despite the intercanine (CC´) and anterior (LL´) widths being significantly narrowed in the BCLP group (CC´ p = 0.019, LL´ p = 0.009). The posterior dental arches were significantly enlarged (UCLP p ≤ 0.001; BCLP p ≤ 0.001). The negative effect of cleft severity on palatal length was not confirmed (p = 0.802). Variability of the palate was immense mainly in BCLP infants (T0); however, it decreased in both cleft types, confirming the formative effect of palatal growth leading to alveolar cleft closure (UCLP p ≤ 0.001; BCLP p = 0.006 on the right, 0.005 on the left). CONCLUSIONS: Both analyzed cleft groups (UCLP, BCLP) grew favorably during the first year of life, and the palatal growth was not limited in any direction. CLINICAL RELEVANCE: Geometric morphometry allowed a comprehensive analysis of the palate, which can contribute to the improvement of surgical methods.
- MeSH
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- rozštěp patra * chirurgie MeSH
- rozštěp rtu * chirurgie MeSH
- zákroky plastické chirurgie * MeSH
- zubní oblouk chirurgie MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- Publikační typ
- časopisecké články MeSH
Objective: To assess the plausibility of using the continuous glucose monitoring as a sole source of data for the screening of the neonatal hypoglycemia.Study design: Infants of mothers with diabetes were screened for neonatal hypoglycemia (less than 2.5 mmol/l after 4 h of life). Initial measurement was performed using point of care analyzer. We applied continuous glucose monitoring system subsequently. Infants were monitored up to 5 days or until discharge.Results: Out of 32 infants 11 had postnatal hypoglycemia resolved within 12 h of life. Two infants had hypoglycemia found due to continuous glucose monitoring after 24 h of life when sufficient feeding was established and they did not show any signs of hypoglycemia. We did not have any false negative measurements. No infant showed clinical signs of neonatal hypoglycemia.Conclusions: Continuous glucose monitoring is plausible and safe to use for screening of neonatal hypoglycemia. It operates well within the range that is accepted as safe for neurodevelopment. In addition, it can be used after first day of life where regular screening ends. Limitation of this method is possible alarm negligence of caregivers.
- MeSH
- biologické markery krev MeSH
- hypoglykemie krev diagnóza MeSH
- krevní glukóza metabolismus MeSH
- lidé MeSH
- monitorování fyziologických funkcí metody MeSH
- novorozenec MeSH
- novorozenecký screening metody MeSH
- studie proveditelnosti MeSH
- těhotenství při diabetu * MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH