Epidemiological studies have shown a clear link between fetal growth retardation and an increased propensity for later cardiovascular disease in adults. It has been hypothesized that such early fetal deprivation "programs" individuals toward a life-long metabolical "thrifty phenotype" that predisposes adults to such diseases. Here we test this hypothesis, and its possible genetic basis, in rat recombinant inbred (RI) strains that uniquely allow the longitudinal studies necessary for its testing. Placental and fetal weights were determined on day 20 of pregnancy in (at least) 6 litters from each of 25 available BXH/HXB RI strains and from their SHR and BN-Lx progenitors and were correlated with metabolic traits determined in adult rats from the same inbred lines. Quantitative trait loci (QTLs) associated with placental and fetal weights were identified by total genome scanning of RI strains using the Map Manager QTX program. Heritabilities of placental and fetal weights were 56% and 62%, respectively, and total genome scanning of RI strains revealed QTLs near the D1Rat266 marker on chromosome 1 and near the D15Rat101 marker on chromosome 15 that were significantly associated with fetal and placental weights respectively. Placental weights correlated with fetal weights (r = 0.60, P = 0.001), while reduced fetal weights correlated with increased insulin concentrations during glucose tolerance test (r = -0.71, P = 0.0001) and with increased serum triglycerides (r = -0.54, P = 0.006) in adult rats. Our results suggest that predisposition toward a thrifty phenotype associated with decreased placental weight and restricted fetal growth is in part genetically determined.
- MeSH
- analýza rozptylu MeSH
- biologické markery analýza MeSH
- fenotyp MeSH
- financování organizované MeSH
- glykogen biosyntéza MeSH
- hmotnost plodu fyziologie MeSH
- inbreeding MeSH
- játra metabolismus MeSH
- kosterní svaly metabolismus MeSH
- krevní glukóza metabolismus MeSH
- krysa rodu rattus MeSH
- lokus kvantitativního znaku genetika MeSH
- mapování chromozomů MeSH
- metabolický syndrom genetika metabolismus patofyziologie MeSH
- placenta růst a vývoj MeSH
- potkani inbrední BN MeSH
- potkani inbrední SHR MeSH
- rekombinace genetická MeSH
- savčí chromozomy genetika MeSH
- těhotenství MeSH
- triglyceridy metabolismus MeSH
- velikost orgánu MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- MeSH
- diabetes mellitus 2. typu etiologie genetika MeSH
- fenotyp MeSH
- financování organizované MeSH
- genetická predispozice k nemoci * MeSH
- genetické testování * metody využití MeSH
- genotyp MeSH
- inzulinová rezistence genetika MeSH
- lokus kvantitativního znaku genetika MeSH
- metabolický syndrom * etiologie genetika MeSH
- porodní hmotnost genetika MeSH
- poruchy výživy plodu genetika MeSH
- potkani inbrední SHR MeSH
- statistika jako téma MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- MeSH
- antigeny CD36 genetika MeSH
- finanční podpora výzkumu jako téma MeSH
- hypertenze genetika komplikace MeSH
- krysa rodu rattus MeSH
- mapování chromozomů MeSH
- mutační analýza DNA MeSH
- potkani inbrední SHR genetika MeSH
- regulace genové exprese imunologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- alely genetika MeSH
- fenotyp genetika MeSH
- genetické markery MeSH
- hypertenze genetika MeSH
- inbrední kmeny potkanů genetika klasifikace MeSH
- krysa rodu rattus MeSH
- mapování chromozomů MeSH
- rekombinace genetická MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
