Amiodarone seems to exhibit some antiviral activity in the disease caused by SARS-CoV-2. Here we have examined the SARS-CoV-2 disease course in the entire population of the Czech Republic and compared it with the course of the disease in patients treated with amiodarone in two major Prague's hospitals. In the whole population of the Czech Republic SARS-CoV-2 infected 1665070 persons (15.6 %) out of 10694000 (100 %) between 1 April 2020 and 30 June 2021. In the same time period only 35 patients (3.4 %) treated with amiodarone were infected with SARS-CoV-2 virus out of 1032 patients (100 %) who received amiodarone. It appears that amiodarone can prevent SARS-CoV-2 virus infection by multiple mechanisms. In in-vitro experiments it exhibits SARS-CoV-2 virus replication inhibitions. Due to its anti-inflammatory and antioxidant properties, it may have beneficial effect on the complications caused by SARS-CoV-2 as well. Additionally, inorganic iodine released from amiodarone can be converted to hypoiodite (IO-), which has antiviral and antibacterial activity, and thus can affect the life cycle of the virus.
- MeSH
- amiodaron * farmakologie terapeutické užití MeSH
- antibakteriální látky MeSH
- antivirové látky farmakologie terapeutické užití MeSH
- COVID-19 * MeSH
- lidé MeSH
- SARS-CoV-2 MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Publikační typ
- abstrakt z konference MeSH
The aim of our study was to address the potential for improvements in thyroid cancer detection in routine clinical settings using a clinical examination, the American College of Radiology Thyroid Imaging Reporting and Database System (ACR TI-RADS), and fine-needle aspiration cytology (FNAC) concurrently with molecular diagnostics. A prospective cohort study was performed on 178 patients. DNA from FNA samples was used for next-generation sequencing to identify mutations in the genes BRAF, HRAS, KRAS, NRAS, and TERT. RNA was used for real-time PCR to detect fusion genes. The strongest relevant positive predictors for malignancy were the presence of genetic mutations (p < 0.01), followed by FNAC (p < 0.01) and ACR TI-RADS (p < 0.01). Overall, FNAC, ACR TI-RADS, and genetic testing reached a sensitivity of up to 96.1% and a specificity of 88.3%, with a diagnostic odds ratio (DOR) of 183.6. Sensitivity, specificity, and DOR decreased to 75.0%, 88.9%, and 24.0, respectively, for indeterminate (Bethesda III, IV) FNAC results. FNA molecular testing has substantial potential for thyroid malignancy detection and could lead to improvements in our approaches to patients. However, clinical examination, ACR TI-RADS, and FNAC remained relevant factors.
- Publikační typ
- časopisecké články MeSH
Subklinická onemocnění štítné žlázy jsou častá, s prevalencí 5–10 %. Diagnózu je vždy nutné potvrdit opakovaným stanovením hladin hormonů štítné žlázy, neboť u subklinické hypotyreózy dochází ke spontánní úpravě hladin hormonů štítné žlázy až ve 40 %. Pacienti se subklinickou hypotyreózou i hypertyreózou mají zvýšenou kardiovaskulární morbiditu a mortalitu. Důležité je potvrdit diagnózu subklinické tyreopatie, odhalit příčinu a pacienty léčit s hladinami TSH v optimálním rozmezí dle věku a přidružených komorbidit.
The prevalence of subclinical thyroid diseases are estimated to be between 5 and 10 %. The diagnosis must always be confirmed through repeated determination of thyroid hormone levels, as spontaneous normalisation of thyroid hormone levels occurs in up to 40 % of patients with subclinical hypothyroidism. Patients with both subclinical hypothyroidism and hyperthyroidism have increased cardiovascular morbidity and mortality. It is important to confirm the diagnosis of subclinical thyroid disease, uncover the cause, and treat patients with optimal TSH levels according to their age and associated comorbidities.
- MeSH
- hypotyreóza MeSH
- lidé MeSH
- nemoci štítné žlázy * MeSH
- rizikové faktory MeSH
- thyroxin farmakologie MeSH
- Check Tag
- lidé MeSH
Nedostatek jodu je celosvětově jedním z hlavních problémů, který dopadá na veřejné zdraví. Den jodu – 6. březen – je věnován odborné i neodborné veřejnosti s cílem zlepšit obecné povědomí o této problematice. Jodový nedostatek je nejčastější, a přitom preventabilní příčinou nevratného poškození mozku dětí. Následně zásadně ovlivňuje sociální a ekonomický rozvoj jednotlivých zemí. Právě proto je důležité pravidelně a systematicky monitorovat zásobení jodem.
Iodine deficiency is one of the main problems affecting public health worldwide. March 6th is the day of iodine that is dedicated to the professional and non‑professional public to improve general awareness of this issue. Iodine deficiency is the most common cause of irreversible brain damage in children that can be avoided. Subsequently, it fundamentally affects the social and economic development of individual countries. Therefore, it is important to regularly and systematically monitor the iodine supply.
- Klíčová slova
- EUthyroid UIC,
- MeSH
- dítě MeSH
- dospělí MeSH
- hypotyreóza diagnóza epidemiologie MeSH
- jod * dějiny moč nedostatek zásobování a distribuce MeSH
- kongenitální hypotyreóza diagnóza prevence a kontrola MeSH
- kuchyňská sůl normy MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- novorozenecký screening dějiny metody MeSH
- plošný screening metody MeSH
- prenatální péče metody MeSH
- těhotenství MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- těhotenství MeSH
BACKGROUND: Diabetes mellitus is unfavorably associated with cancer risk. The purpose of this multidisciplinary project was to evaluate a possible association of diabetes mellitus and other comorbidities and their treatment with progression of colorectal cancer. PATIENTS AND METHODS: We investigated the correlation between pathological characteristics and clinical course, including comorbidities in 1004 Czech patients diagnosed and surgically treated for colorectal adenocarcinoma (CRC) between 1999 and 2016. RESULTS: In our data set, CRC patients treated with metformin due to coexisting diabetes mellitus type 2 (T2DM) developed fewer distant metastases which clinically correlates with slower CRC progression. Survival in metformin subgroup was longer, particularly in men with CRC. Osteoporosis may be a negative factor of survival in CRC patients. CONCLUSIONS: Our findings also indicate that aging, higher tumor grade and TNM stage, coexistence of selected endocrine disorders, and metabolic abnormalities may change the tumor microenvironment and impact survival in colorectal cancer, although mechanism of these observations yet to be explained. Patients with diabetes mellitus type 2 treated with metformin may represent the altered microenvironment with specifically tuned metabolic molecular responses and with various epigenetic characteristics. More awareness and increased understanding of the mechanisms underlying the positive effect of metformin on patients' survival could offer insight into new treatment methods and permit more individualized treatment plans.
- Publikační typ
- časopisecké články MeSH
[Mitochondrial diabetes in common clinical practice]
Primární mitochondriální onemocnění jsou heterogenní a komplexní skupinou, kdy se jednáo vrozenou poruchu metabolismu energie a tvorby ATP. Prvním pojmenovaným mitochon-driálním onemocněním je MELAS (mitochondrial encephalomyopathy with lactic acidosisand stroke-like episodes) způsobené mutací mitochondriální DNA, které je velmi často spo-jeno s přítomností diabetes mellitus. Kazuistika je věnována pacientce s mitochondriálnímdiabetem a snaží se určit, kdy je vhodné na onemocnění pomýšlet v běžné praxi diabetologaa jak volit správnou léčbu.
Primary mitochondrial diseases are a heterogeneous and complex group. Usually, they area congenital disorder of energy metabolism and ATP production. The first named mitochon-drial disease is MELAS (mitochondrial encephalomyopathy with lactic acidosis andstroke-like episodes) caused by mitochondrial DNA mutation. MELAS syndrome is veryoften associated with the presence of diabetes mellitus. The case report describes a femalepatient with mitochondrial diabetes, and also tries to determine when it is appropriate toconsider the disease in common practice of a diabetologist and how to choose the right treat-ment.
- MeSH
- diabetes mellitus genetika MeSH
- dospělí MeSH
- lidé MeSH
- metabolické nemoci diagnóza MeSH
- mitochondriální DNA genetika MeSH
- mitochondriální nemoci MeSH
- mitochondrie MeSH
- nedoslýchavost MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
