- Gruchot, Joel
- Lein, Ferdinand
- Lewen, Isabel
- Reiche, Laura
- Weyers, Vivien
- Petzsch, Patrick
- Göttle, Peter
- Köhrer, Karl
-
Hartung, Hans-Peter
Autor Hartung, Hans-Peter Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, D-40225 Dusseldorf, Germany Brain and Mind Center, University of Sydney, Sydney, NSW 2050, Australia Department of Neurology, Palacky University Olomouc, 77146 Olomouc, Czech Republic
- Küry, Patrick
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PubMed
36362063
DOI
10.3390/ijms232113278
Knihovny.cz E-zdroje
Siponimod (Mayzent®), a sphingosine 1-phosphate receptor (S1PR) modulator which prevents lymphocyte egress from lymphoid tissues, is approved for the treatment of relapsing-remitting and active secondary progressive multiple sclerosis. It can cross the blood-brain barrier (BBB) and selectively binds to S1PR1 and S1PR5 expressed by several cell populations of the central nervous system (CNS) including microglia. In multiple sclerosis, microglia are a key CNS cell population moving back and forth in a continuum of beneficial and deleterious states. On the one hand, they can contribute to neurorepair by clearing myelin debris, which is a prerequisite for remyelination and neuroprotection. On the other hand, they also participate in autoimmune inflammation and axonal degeneration by producing pro-inflammatory cytokines and molecules. In this study, we demonstrate that siponimod can modulate the microglial reaction to lipopolysaccharide-induced pro-inflammatory activation.
- MeSH
- azetidiny * farmakologie metabolismus MeSH
- benzylové sloučeniny farmakologie MeSH
- lidé MeSH
- mikroglie metabolismus MeSH
- roztroušená skleróza * metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
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