Background and objectives: Atherosclerosis is the underlying pathology of ischemic heart disease. There are many aggravating metabolic and oxidant parameters which are participating together overwhelming the pathology of vascular stenosis. Adipokines play a positive metabolic effect in healthy individuals and oxidation reaction greatly impacts the lipid metabolism and might negatively impact the condition. In the present study, we aimed to characterize the level of adiponectin, obestatin, and redox parameters in atherosclerotic patients.Methods: Serum was collected from atherosclerotic patients and froze to be ready for analysis.Results: The results indicated that hyperlipidemia significantly reduced adiponectin, obestatin, and antioxidant enzymes (catalase, glutathione, glutathione-S-transferase, and glutathione peroxidase) together with a significant increase in oxidant byproduct (malondialdehyde) and modulated lipid parameters (cholesterol, triglyceride, and high-density lipoprotein).Conclusion: The study concluded that atherosclerosis is associated with reduced antioxidant enzymes, obestatin, and adiponectin levels and increased lipid levels. These parameters play a great role in the patho-logical status of coronary stenosis.
- MeSH
- adiponektin krev metabolismus MeSH
- antioxidancia analýza metabolismus MeSH
- ateroskleróza etiologie patofyziologie MeSH
- ELISA MeSH
- ghrelin krev metabolismus MeSH
- hyperlipidemie * diagnóza etiologie patofyziologie MeSH
- koronární stenóza patofyziologie MeSH
- lidé MeSH
- malondialdehyd krev metabolismus MeSH
- metabolismus lipidů MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- klinická studie MeSH
Based on many reports, an unmistakable link probably exists between diabetes mellitus and COVID-19. A major predisposing factor determining severity and mortality of COVID-19 is diabetes mellitus, diabetic patients were shown to be at higher risk for developing severe COVID-19 disease than non-diabetics; many recent studies reported a striking prevalence of DM in those diagnosed with COVID-19. Accordingly, antidiabetic drugs can possibly impact the clinical course and / or the outcome of this infection, either by alleviating diabetes-associated symptoms, minimizing its complications, or by mitigating or aggravating COVID-19 disease by effects independent from their direct antidiabetic effects. Several antidiabetic drug classes were shown to have varying effects, like blocking viral entry to cells, as well as having immunomodulatory, anti-inflammatory, antifibrotic, or cardioprotective effects; such effects could prove beneficial for COVID-19 patients. On the other hand, some antidiabetic agents may have adverse effects that aggravate patients' condition like hypoglycemia, fluid retention, increased weight or lactic acidosis, which require special consideration in patient management. Some of the drugs were found in observational studies to either reduce mortality from COVID-19 or pose no harm, but more solid evidence from clinical trials is still lacking.
- MeSH
- COVID-19 * etiologie komplikace MeSH
- hypoglykemika škodlivé účinky MeSH
- komplikace diabetu * MeSH
- lidé MeSH
- metformin škodlivé účinky MeSH
- nežádoucí účinky léčiv MeSH
- rizikové faktory MeSH
- sulfonylmočovinové sloučeniny škodlivé účinky MeSH
- thiazolidindiony škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
The ventricular septal defect (VSD) is a congenital lesion characterized by the presence of an opening between cardiac chambers. The treatment might involve medical therapy to control symptoms or in certain cases, surgical resuscitation might be required.Objectives: The study was conducted to establish a database about the prevalence and pattern of VSD and their prognosis in children referred to by echocardiography in Ibn-Sena Teaching Hospital over the period of March 2019 to January 2020. Method: The present study is a prospective descriptive study conducted on all patients diagnosed with cardiac lesions revealed by echocardiography. The sample included in the study involves newborns (day 1) to 14-years-old children.Result: Out of 500 children included in the study; most of these cases were cyanotic congenital heart lesions and out of which two-third were perimembranous defects.Conclusion: The study concluded a higher prevalence of non-cyanotic lesions and peri-membranous type is the commonest VSD lesion.
Vitamin D inadequacy is widespread in females with polycystic ovarian syndrome (PCOS), with blood values of 25-hydroxy vitamin D (25OHD) down to or less than 20 ng/ml in two-third of PCOS patients. Decreased 25OHD concentrations have been linked to insulin resistance, ovulatory and period abnormalities, lower pregnancy outcomes, and other indications of PCOS, according to epidemiological studies. There might be some, but inadequate, research that vitamin D supplements can help women with PCOS with menstruation disruption and insulin sensitivity. Vitamin D inadequacy may bestow to the exacerbation of PCOS, and vitamin D intake may be helpful in the treatment of this condition. However, the present evidence is insufficient, and further experimental investigations are in need to establish vitamin D supplementation's potential advantages in this population. Many investigators claimed a pertinency between vitamin D concentrations and PCOS, nevertheless, these researches bear rattle factors of conjoined with other disorders or ailments, such as obesity, diabetes, and hirsutism. In the view of this, the present review detailed the role of vitamin D inadequacy and related biomolecule abnormalities, including sex hormones, and insulin and we listed their psychological and cardiovascular encounter. We concluded that the correlation between vitamin D intake and mended PCOS prominence is dubious and no definite findings attained by studies conducted across multicentral laboratories.
- MeSH
- lidé MeSH
- nedostatek vitaminu D * MeSH
- syndrom polycystických ovarií * farmakoterapie patofyziologie MeSH
- vitamin D terapeutické užití MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- přehledy MeSH
