Ceramides are a family of lipids constituted by a sphingoid base and a fatty acid. In the skin, they are mainly present in the stratum corneum where, with cholesterol and free fatty acids, they constitute the inter-corneocyte lipids. With the other lipid groups, they play a key role in the formation of dense lamellar structures between adjacent corneocytes, collectively ensuring the vital efficient barrier to water evaporation and protection from foreign agents ́ penetration. Changes in ceramide level and relative composition, with potential impairment of lipid arrangement, have been evidenced in different skin conditions and skin diseases. Therefore, use of suitably formulated ceramides has been proposed for topical treatment to help re-structure damaged lipid arrangement and repair impaired skin barrier function. Nonetheless, the formulation of ceramides in products necessitates specific processes such as heating to high temperature before their introduction in the final formula. In this review on the structure, the role and the potential of ceramides for skincare, we point out the necessity of rigorous process when formulating ceramides into the final product. We demonstrate the counterproductive effects of undissolved ceramides on skin barrier repair capacity of the formulas, when assessed in different in vitro models of disrupted skin barrier.
- MeSH
- ceramidy * chemie MeSH
- kůže * metabolismus MeSH
- lidé MeSH
- péče o kůži * metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Kůže je největší orgán lidského těla a je významným indikátorem interních chorob. Projevy na kůži a sliznicích mohou být prvními příznaky závažných interních onemocnění. Díky vývoji moderní cílené terapie se v posledních letech setkáváme se vzrůstajícím počtem přeživších pacientů. Péče o kůži onkologických pacientů si tedy zaslouží zvláštní péči. Kožní změny u onkologických pacientů jsou velmi rozmanité. V našem článku se budeme věnovat především nežádoucím účinkům onkologické terapie a péči o kůži.
Skin is the biggest organ that indicates internal diseases. Skin and mucous membrane manifestations can be initial symptoms during serious internal diseases. The number of patients living with cancer has increased, and this is the reason, why the skin deserves specific attention. Dermatologic symptoms are very different. We focus on adverse effects during cancer treatment and skin care.
- MeSH
- cílená molekulární terapie škodlivé účinky MeSH
- imunoterapie škodlivé účinky MeSH
- kožní nemoci chemicky indukované patologie prevence a kontrola MeSH
- lidé MeSH
- nádory * komplikace MeSH
- nežádoucí účinky léčiv patologie prevence a kontrola MeSH
- péče o kůži * metody MeSH
- radiodermatitida chemicky indukované patologie prevence a kontrola MeSH
- radioterapie škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Introduction: Pressure injuries have been identified as a problem in adults, but there is increasing recognition that they also occur in pediatric patients. Specific prevention in this population is essential because a high percentage of pressure injuries can be prevented. Objective: To identify interventions that prevent pressure injuries in the clinical pediatric care setting. Methods: Systematic review with a conducted search in CINAHL, PubMed, and Cochrane databases. A total of 301 articles were found, 225 were excluded after reviewing the title and abstract. The remaining papers were subjected to a full-text screening. Eligible studies were those that (a) described interventions to prevent pressure injuries, (b) were specifically aimed at pediatric patients (0-18 years), (c) were published in English or German, and (d) were conducted in a hospital. Results: A total of 37 studies were included. The data on interventions from the studies were extracted and clustered. The following eight categories of interventions for the prevention of pressure injury in pediatric patients were identified: (1) (Skin)Assessments, (2) Medical devices, (3) Positioning, (4) Education, (5) Moisture Management, (6) Nutrition Management, (7) Surfaces, and (8) Intervention bundles. The included studies described various interventions for pressure injury prevention. Most reported a significant reduction in pressure injury rates when intervention bundles were implemented. Conclusion: Nurses have to know about pressure injury causation, risk factors, and prevention strategies to implement the identified interventions and prevent pressure injuries in pediatric patients during hospital stays.
- MeSH
- gestační diabetes MeSH
- imunosupresiva terapeutické užití MeSH
- imunosupresivní léčba metody MeSH
- kombinovaná farmakoterapie metody MeSH
- komplikace těhotenství MeSH
- péče o kůži MeSH
- pyoderma gangrenosum * komplikace terapie MeSH
- těhotenství MeSH
- ulcerózní kolitida MeSH
- Check Tag
- těhotenství MeSH
- Publikační typ
- kazuistiky MeSH
- Klíčová slova
- Abilar,
- MeSH
- dekubity terapie MeSH
- dermatologické látky * MeSH
- hojení ran * MeSH
- lidé středního věku MeSH
- masti MeSH
- péče o kůži metody MeSH
- popálení terapie MeSH
- rostlinné pryskyřice MeSH
- senioři MeSH
- smrk MeSH
- Check Tag
- lidé středního věku MeSH
- senioři MeSH
- Publikační typ
- inzerce MeSH
- kazuistiky MeSH
- MeSH
- dospělí MeSH
- imunosupresiva terapeutické užití MeSH
- imunosupresivní léčba metody MeSH
- kombinovaná farmakoterapie metody MeSH
- komplikace těhotenství MeSH
- lidé MeSH
- péče o kůži metody MeSH
- pyoderma gangrenosum * komplikace terapie MeSH
- těhotenství MeSH
- ulcerózní kolitida MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
