The aim of this publication is to compile a summary of the findings regarding punicalagin in various tissues described thus far in the literature, with an emphasis on the effect of this substance on immune reactions. Punicalagin (PUN) is an ellagitannin found in the peel of pomegranate (Punica granatum). It is a polyphenol with proven antioxidant, hepatoprotective, anti-atherosclerotic and chemopreventive activities, antiproliferative activity against tumor cells; it inhibits inflammatory pathways and the action of toxic substances, and is highly tolerated. This work describes the source, metabolism, functions and effects of punicalagin, its derivatives and metabolites. Furthermore, its anti-inflammatory and antioxidant effects are described.

• MeSH
• antiflogistika farmakologie   MeSH
• biologická dostupnost MeSH
• hydrolyzovatelné taniny imunologie   metabolismus   MeSH
• imunosupresiva farmakologie   MeSH
• kyselina ellagová analýza   MeSH
• lidé MeSH
• metabolom MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

In Italy a particularly valuable chestnut is "Marrone di Roccadaspide", a protected geographical indication (PGI) product, deriving from a Castanea sativa cultivar, typical of Salerno province in Campania region. As chestnut industrial processes yield a large amount of shell by-products, in this study the possibility to retrain this waste food as potential source of bioactives was investigated. The ability of "Marrone di Roccadaspide" shell MeOH extract to modulate the pro-inflammatory transcriptional factor NF-κB after LPS stimulation, along with the antioxidant activity by a cell-based in vitro test, were evaluated. To correlate the NF-κB inhibition (67.67% at 5 μg/mL) and the strong antioxidant activity to the chemical composition, an analytical approach based on LC-ESI/LTQOrbitrap/MS/MSn along with NMR characterization of isolated compounds was developed. The identification of hydrolysable and condensed tannins, along with flavonoids, phenol glucosides, ellagic acid derivatives, and triterpenoids was accomplished. The most representative compounds were quantitatively analyzed by LC-ESI/QTrap/MS/MS, showing bartogenic acid as the compound occurring in the highest amount (103.08 mg/100 g shells). With the aim to explore the possibility to employ chestnut shells as suitable source of bioactives for the preparation of functional ingredients, the chemical composition and the antioxidant activity of "eco-friendly" extracts (EtOH and EtOH:H2O 7:3) was finally evaluated, showing a high superimposability of the EtOH:H2O (7:3) extract to the MeOH extract.

• MeSH
• antioxidancia analýza   MeSH
• Fagaceae chemie   MeSH
• fenoly analýza   MeSH
• flavonoidy analýza   MeSH
• glukosidy analýza   MeSH
• hodnotící studie jako téma MeSH
• hydrolyzovatelné taniny analýza   MeSH
• kalibrace MeSH
• kyselina ellagová analýza   MeSH
• lidé MeSH
• NF-kappa B metabolismus   MeSH
• ořechy chemie   MeSH
• proantokyanidiny analýza   MeSH
• proliferace buněk MeSH
• racionalizace * MeSH
• reaktivní formy kyslíku MeSH
• rostlinné extrakty analýza   MeSH
• tandemová hmotnostní spektrometrie MeSH
• taniny analýza   MeSH
• triterpeny analýza   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Itálie MeSH