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MeSH: porucha chování v REM spánku-epidemiologie

7 záznamů v Články Filtry

Článek

Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder

Mufti, Kheireddin
Autor Mufti, Kheireddin From the Department of Human Genetics (K.M., E.Y., U.R., L.K., G.A.R., Z.G.-O.), Montreal Neurological Institute (K.M., E.Y., U.R., L.K., J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Department of Neurology and Neurosurgery (J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Centre de Recherche en Biologie Structurale (J.-F.T.), and Department of Pharmacology and Therapeutics (J.-F.T.), McGill University, Montréal, Quebec, Canada Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, France Oxford Parkinson's Disease Centre (OPDC) (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK Center for Advanced Research in Sleep Medicine (J.Y.M., J.-F.G., A.D., R.B.P.), Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal-Hôpital du Sacré-Coeur de Montréal Departments of Psychiatry (J.Y.M.) and Neurosciences (A.D.), Université de Montréal Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada National Reference Center for Narcolepsy (Y.D.), Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France Clinical Neurology Unit (G.L.G., M.V., F.J., A.B.), Department of Neurosciences, University Hospital of Udine DMIF (G.L.G.) and Department of Medicine (DAME) (M.V.), University of Udine, Italy Sleep Disorders Clinic (B.H., A.S., E.H.), Department of Neurology, Medical University of Innsbruck, Austria Department of Neurology (K.S., D.K.) and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Neurology (W.O., A.J., F.S.-D.), Philipps University, Marburg, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio-Emilia IRCCS (G.P.), Institute of Neurological Sciences of Bologna Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona Department of Medical Sciences and Public Health (M.F., M.P.), Sleep Disorder Research Center, University of Cagliari, Italy Paracelsus-Elena-Klinik (B.M., C.T., F.S.-D.), Kassel Department of Neurosurgery (B.M., C.T.), University Medical Centre Göttingen, Germany Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic EuroMov Digital Health in Motion (V.C.D.C.), University of Montpellier IMT Mines Ales University Lille North of France (C.C.M.), Department of Clinical Neurophysiology and Sleep Center, CHU Lille Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Müenster, Germany Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel Department of Neurology (F.D.), University Hospital Antwerp, Edegem, Belgium Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France and Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN
Yu, Eric
Autor Yu, Eric From the Department of Human Genetics (K.M., E.Y., U.R., L.K., G.A.R., Z.G.-O.), Montreal Neurological Institute (K.M., E.Y., U.R., L.K., J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Department of Neurology and Neurosurgery (J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Centre de Recherche en Biologie Structurale (J.-F.T.), and Department of Pharmacology and Therapeutics (J.-F.T.), McGill University, Montréal, Quebec, Canada Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, France Oxford Parkinson's Disease Centre (OPDC) (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK Center for Advanced Research in Sleep Medicine (J.Y.M., J.-F.G., A.D., R.B.P.), Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal-Hôpital du Sacré-Coeur de Montréal Departments of Psychiatry (J.Y.M.) and Neurosciences (A.D.), Université de Montréal Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada National Reference Center for Narcolepsy (Y.D.), Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France Clinical Neurology Unit (G.L.G., M.V., F.J., A.B.), Department of Neurosciences, University Hospital of Udine DMIF (G.L.G.) and Department of Medicine (DAME) (M.V.), University of Udine, Italy Sleep Disorders Clinic (B.H., A.S., E.H.), Department of Neurology, Medical University of Innsbruck, Austria Department of Neurology (K.S., D.K.) and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Neurology (W.O., A.J., F.S.-D.), Philipps University, Marburg, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio-Emilia IRCCS (G.P.), Institute of Neurological Sciences of Bologna Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona Department of Medical Sciences and Public Health (M.F., M.P.), Sleep Disorder Research Center, University of Cagliari, Italy Paracelsus-Elena-Klinik (B.M., C.T., F.S.-D.), Kassel Department of Neurosurgery (B.M., C.T.), University Medical Centre Göttingen, Germany Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic EuroMov Digital Health in Motion (V.C.D.C.), University of Montpellier IMT Mines Ales University Lille North of France (C.C.M.), Department of Clinical Neurophysiology and Sleep Center, CHU Lille Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Müenster, Germany Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel Department of Neurology (F.D.), University Hospital Antwerp, Edegem, Belgium Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France and Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN
Rudakou, Uladzislau
Autor Rudakou, Uladzislau From the Department of Human Genetics (K.M., E.Y., U.R., L.K., G.A.R., Z.G.-O.), Montreal Neurological Institute (K.M., E.Y., U.R., L.K., J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Department of Neurology and Neurosurgery (J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Centre de Recherche en Biologie Structurale (J.-F.T.), and Department of Pharmacology and Therapeutics (J.-F.T.), McGill University, Montréal, Quebec, Canada Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, France Oxford Parkinson's Disease Centre (OPDC) (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK Center for Advanced Research in Sleep Medicine (J.Y.M., J.-F.G., A.D., R.B.P.), Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal-Hôpital du Sacré-Coeur de Montréal Departments of Psychiatry (J.Y.M.) and Neurosciences (A.D.), Université de Montréal Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada National Reference Center for Narcolepsy (Y.D.), Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France Clinical Neurology Unit (G.L.G., M.V., F.J., A.B.), Department of Neurosciences, University Hospital of Udine DMIF (G.L.G.) and Department of Medicine (DAME) (M.V.), University of Udine, Italy Sleep Disorders Clinic (B.H., A.S., E.H.), Department of Neurology, Medical University of Innsbruck, Austria Department of Neurology (K.S., D.K.) and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Neurology (W.O., A.J., F.S.-D.), Philipps University, Marburg, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio-Emilia IRCCS (G.P.), Institute of Neurological Sciences of Bologna Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona Department of Medical Sciences and Public Health (M.F., M.P.), Sleep Disorder Research Center, University of Cagliari, Italy Paracelsus-Elena-Klinik (B.M., C.T., F.S.-D.), Kassel Department of Neurosurgery (B.M., C.T.), University Medical Centre Göttingen, Germany Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic EuroMov Digital Health in Motion (V.C.D.C.), University of Montpellier IMT Mines Ales University Lille North of France (C.C.M.), Department of Clinical Neurophysiology and Sleep Center, CHU Lille Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Müenster, Germany Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel Department of Neurology (F.D.), University Hospital Antwerp, Edegem, Belgium Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France and Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN
Krohn, Lynne
Autor Krohn, Lynne From the Department of Human Genetics (K.M., E.Y., U.R., L.K., G.A.R., Z.G.-O.), Montreal Neurological Institute (K.M., E.Y., U.R., L.K., J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Department of Neurology and Neurosurgery (J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Centre de Recherche en Biologie Structurale (J.-F.T.), and Department of Pharmacology and Therapeutics (J.-F.T.), McGill University, Montréal, Quebec, Canada Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, France Oxford Parkinson's Disease Centre (OPDC) (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK Center for Advanced Research in Sleep Medicine (J.Y.M., J.-F.G., A.D., R.B.P.), Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal-Hôpital du Sacré-Coeur de Montréal Departments of Psychiatry (J.Y.M.) and Neurosciences (A.D.), Université de Montréal Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada National Reference Center for Narcolepsy (Y.D.), Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France Clinical Neurology Unit (G.L.G., M.V., F.J., A.B.), Department of Neurosciences, University Hospital of Udine DMIF (G.L.G.) and Department of Medicine (DAME) (M.V.), University of Udine, Italy Sleep Disorders Clinic (B.H., A.S., E.H.), Department of Neurology, Medical University of Innsbruck, Austria Department of Neurology (K.S., D.K.) and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Neurology (W.O., A.J., F.S.-D.), Philipps University, Marburg, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio-Emilia IRCCS (G.P.), Institute of Neurological Sciences of Bologna Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona Department of Medical Sciences and Public Health (M.F., M.P.), Sleep Disorder Research Center, University of Cagliari, Italy Paracelsus-Elena-Klinik (B.M., C.T., F.S.-D.), Kassel Department of Neurosurgery (B.M., C.T.), University Medical Centre Göttingen, Germany Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic EuroMov Digital Health in Motion (V.C.D.C.), University of Montpellier IMT Mines Ales University Lille North of France (C.C.M.), Department of Clinical Neurophysiology and Sleep Center, CHU Lille Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Müenster, Germany Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel Department of Neurology (F.D.), University Hospital Antwerp, Edegem, Belgium Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France and Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN
Ruskey, Jennifer A
Autor Ruskey, Jennifer A From the Department of Human Genetics (K.M., E.Y., U.R., L.K., G.A.R., Z.G.-O.), Montreal Neurological Institute (K.M., E.Y., U.R., L.K., J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Department of Neurology and Neurosurgery (J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Centre de Recherche en Biologie Structurale (J.-F.T.), and Department of Pharmacology and Therapeutics (J.-F.T.), McGill University, Montréal, Quebec, Canada Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, France Oxford Parkinson's Disease Centre (OPDC) (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK Center for Advanced Research in Sleep Medicine (J.Y.M., J.-F.G., A.D., R.B.P.), Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal-Hôpital du Sacré-Coeur de Montréal Departments of Psychiatry (J.Y.M.) and Neurosciences (A.D.), Université de Montréal Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada National Reference Center for Narcolepsy (Y.D.), Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France Clinical Neurology Unit (G.L.G., M.V., F.J., A.B.), Department of Neurosciences, University Hospital of Udine DMIF (G.L.G.) and Department of Medicine (DAME) (M.V.), University of Udine, Italy Sleep Disorders Clinic (B.H., A.S., E.H.), Department of Neurology, Medical University of Innsbruck, Austria Department of Neurology (K.S., D.K.) and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Neurology (W.O., A.J., F.S.-D.), Philipps University, Marburg, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio-Emilia IRCCS (G.P.), Institute of Neurological Sciences of Bologna Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona Department of Medical Sciences and Public Health (M.F., M.P.), Sleep Disorder Research Center, University of Cagliari, Italy Paracelsus-Elena-Klinik (B.M., C.T., F.S.-D.), Kassel Department of Neurosurgery (B.M., C.T.), University Medical Centre Göttingen, Germany Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic EuroMov Digital Health in Motion (V.C.D.C.), University of Montpellier IMT Mines Ales University Lille North of France (C.C.M.), Department of Clinical Neurophysiology and Sleep Center, CHU Lille Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Müenster, Germany Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel Department of Neurology (F.D.), University Hospital Antwerp, Edegem, Belgium Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France and Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN
Asayesh, Farnaz
Autor Asayesh, Farnaz From the Department of Human Genetics (K.M., E.Y., U.R., L.K., G.A.R., Z.G.-O.), Montreal Neurological Institute (K.M., E.Y., U.R., L.K., J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Department of Neurology and Neurosurgery (J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Centre de Recherche en Biologie Structurale (J.-F.T.), and Department of Pharmacology and Therapeutics (J.-F.T.), McGill University, Montréal, Quebec, Canada Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, France Oxford Parkinson's Disease Centre (OPDC) (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK Center for Advanced Research in Sleep Medicine (J.Y.M., J.-F.G., A.D., R.B.P.), Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal-Hôpital du Sacré-Coeur de Montréal Departments of Psychiatry (J.Y.M.) and Neurosciences (A.D.), Université de Montréal Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada National Reference Center for Narcolepsy (Y.D.), Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France Clinical Neurology Unit (G.L.G., M.V., F.J., A.B.), Department of Neurosciences, University Hospital of Udine DMIF (G.L.G.) and Department of Medicine (DAME) (M.V.), University of Udine, Italy Sleep Disorders Clinic (B.H., A.S., E.H.), Department of Neurology, Medical University of Innsbruck, Austria Department of Neurology (K.S., D.K.) and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Neurology (W.O., A.J., F.S.-D.), Philipps University, Marburg, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio-Emilia IRCCS (G.P.), Institute of Neurological Sciences of Bologna Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona Department of Medical Sciences and Public Health (M.F., M.P.), Sleep Disorder Research Center, University of Cagliari, Italy Paracelsus-Elena-Klinik (B.M., C.T., F.S.-D.), Kassel Department of Neurosurgery (B.M., C.T.), University Medical Centre Göttingen, Germany Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic EuroMov Digital Health in Motion (V.C.D.C.), University of Montpellier IMT Mines Ales University Lille North of France (C.C.M.), Department of Clinical Neurophysiology and Sleep Center, CHU Lille Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Müenster, Germany Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel Department of Neurology (F.D.), University Hospital Antwerp, Edegem, Belgium Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France and Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN
Laurent, Sandra B
Autor Laurent, Sandra B From the Department of Human Genetics (K.M., E.Y., U.R., L.K., G.A.R., Z.G.-O.), Montreal Neurological Institute (K.M., E.Y., U.R., L.K., J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Department of Neurology and Neurosurgery (J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Centre de Recherche en Biologie Structurale (J.-F.T.), and Department of Pharmacology and Therapeutics (J.-F.T.), McGill University, Montréal, Quebec, Canada Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, France Oxford Parkinson's Disease Centre (OPDC) (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK Center for Advanced Research in Sleep Medicine (J.Y.M., J.-F.G., A.D., R.B.P.), Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal-Hôpital du Sacré-Coeur de Montréal Departments of Psychiatry (J.Y.M.) and Neurosciences (A.D.), Université de Montréal Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada National Reference Center for Narcolepsy (Y.D.), Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France Clinical Neurology Unit (G.L.G., M.V., F.J., A.B.), Department of Neurosciences, University Hospital of Udine DMIF (G.L.G.) and Department of Medicine (DAME) (M.V.), University of Udine, Italy Sleep Disorders Clinic (B.H., A.S., E.H.), Department of Neurology, Medical University of Innsbruck, Austria Department of Neurology (K.S., D.K.) and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Neurology (W.O., A.J., F.S.-D.), Philipps University, Marburg, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio-Emilia IRCCS (G.P.), Institute of Neurological Sciences of Bologna Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona Department of Medical Sciences and Public Health (M.F., M.P.), Sleep Disorder Research Center, University of Cagliari, Italy Paracelsus-Elena-Klinik (B.M., C.T., F.S.-D.), Kassel Department of Neurosurgery (B.M., C.T.), University Medical Centre Göttingen, Germany Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic EuroMov Digital Health in Motion (V.C.D.C.), University of Montpellier IMT Mines Ales University Lille North of France (C.C.M.), Department of Clinical Neurophysiology and Sleep Center, CHU Lille Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Müenster, Germany Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel Department of Neurology (F.D.), University Hospital Antwerp, Edegem, Belgium Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France and Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN
Spiegelman, Dan
Autor Spiegelman, Dan From the Department of Human Genetics (K.M., E.Y., U.R., L.K., G.A.R., Z.G.-O.), Montreal Neurological Institute (K.M., E.Y., U.R., L.K., J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Department of Neurology and Neurosurgery (J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Centre de Recherche en Biologie Structurale (J.-F.T.), and Department of Pharmacology and Therapeutics (J.-F.T.), McGill University, Montréal, Quebec, Canada Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, France Oxford Parkinson's Disease Centre (OPDC) (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK Center for Advanced Research in Sleep Medicine (J.Y.M., J.-F.G., A.D., R.B.P.), Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal-Hôpital du Sacré-Coeur de Montréal Departments of Psychiatry (J.Y.M.) and Neurosciences (A.D.), Université de Montréal Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada National Reference Center for Narcolepsy (Y.D.), Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France Clinical Neurology Unit (G.L.G., M.V., F.J., A.B.), Department of Neurosciences, University Hospital of Udine DMIF (G.L.G.) and Department of Medicine (DAME) (M.V.), University of Udine, Italy Sleep Disorders Clinic (B.H., A.S., E.H.), Department of Neurology, Medical University of Innsbruck, Austria Department of Neurology (K.S., D.K.) and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Neurology (W.O., A.J., F.S.-D.), Philipps University, Marburg, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio-Emilia IRCCS (G.P.), Institute of Neurological Sciences of Bologna Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona Department of Medical Sciences and Public Health (M.F., M.P.), Sleep Disorder Research Center, University of Cagliari, Italy Paracelsus-Elena-Klinik (B.M., C.T., F.S.-D.), Kassel Department of Neurosurgery (B.M., C.T.), University Medical Centre Göttingen, Germany Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic EuroMov Digital Health in Motion (V.C.D.C.), University of Montpellier IMT Mines Ales University Lille North of France (C.C.M.), Department of Clinical Neurophysiology and Sleep Center, CHU Lille Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Müenster, Germany Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel Department of Neurology (F.D.), University Hospital Antwerp, Edegem, Belgium Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France and Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN
Arnulf, Isabelle
Autor Arnulf, Isabelle From the Department of Human Genetics (K.M., E.Y., U.R., L.K., G.A.R., Z.G.-O.), Montreal Neurological Institute (K.M., E.Y., U.R., L.K., J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Department of Neurology and Neurosurgery (J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Centre de Recherche en Biologie Structurale (J.-F.T.), and Department of Pharmacology and Therapeutics (J.-F.T.), McGill University, Montréal, Quebec, Canada Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, France Oxford Parkinson's Disease Centre (OPDC) (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK Center for Advanced Research in Sleep Medicine (J.Y.M., J.-F.G., A.D., R.B.P.), Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal-Hôpital du Sacré-Coeur de Montréal Departments of Psychiatry (J.Y.M.) and Neurosciences (A.D.), Université de Montréal Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada National Reference Center for Narcolepsy (Y.D.), Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France Clinical Neurology Unit (G.L.G., M.V., F.J., A.B.), Department of Neurosciences, University Hospital of Udine DMIF (G.L.G.) and Department of Medicine (DAME) (M.V.), University of Udine, Italy Sleep Disorders Clinic (B.H., A.S., E.H.), Department of Neurology, Medical University of Innsbruck, Austria Department of Neurology (K.S., D.K.) and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Neurology (W.O., A.J., F.S.-D.), Philipps University, Marburg, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio-Emilia IRCCS (G.P.), Institute of Neurological Sciences of Bologna Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona Department of Medical Sciences and Public Health (M.F., M.P.), Sleep Disorder Research Center, University of Cagliari, Italy Paracelsus-Elena-Klinik (B.M., C.T., F.S.-D.), Kassel Department of Neurosurgery (B.M., C.T.), University Medical Centre Göttingen, Germany Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic EuroMov Digital Health in Motion (V.C.D.C.), University of Montpellier IMT Mines Ales University Lille North of France (C.C.M.), Department of Clinical Neurophysiology and Sleep Center, CHU Lille Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Müenster, Germany Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel Department of Neurology (F.D.), University Hospital Antwerp, Edegem, Belgium Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France and Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN
Hu, Michele T M
Autor Hu, Michele T M From the Department of Human Genetics (K.M., E.Y., U.R., L.K., G.A.R., Z.G.-O.), Montreal Neurological Institute (K.M., E.Y., U.R., L.K., J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Department of Neurology and Neurosurgery (J.A.R., F.A., S.B.L., D.S., G.A.R., R.B.P., Z.G.-O.), Centre de Recherche en Biologie Structurale (J.-F.T.), and Department of Pharmacology and Therapeutics (J.-F.T.), McGill University, Montréal, Quebec, Canada Sleep Disorders Unit (I.A.), Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, France Oxford Parkinson's Disease Centre (OPDC) (M.T.M.H.) and Nuffield Department of Clinical Neurosciences (M.T.M.H.), University of Oxford, UK Center for Advanced Research in Sleep Medicine (J.Y.M., J.-F.G., A.D., R.B.P.), Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal-Hôpital du Sacré-Coeur de Montréal Departments of Psychiatry (J.Y.M.) and Neurosciences (A.D.), Université de Montréal Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada National Reference Center for Narcolepsy (Y.D.), Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, France Clinical Neurology Unit (G.L.G., M.V., F.J., A.B.), Department of Neurosciences, University Hospital of Udine DMIF (G.L.G.) and Department of Medicine (DAME) (M.V.), University of Udine, Italy Sleep Disorders Clinic (B.H., A.S., E.H.), Department of Neurology, Medical University of Innsbruck, Austria Department of Neurology (K.S., D.K.) and Centre of Clinical Neuroscience (K.S., D.K.), Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Neurology (W.O., A.J., F.S.-D.), Philipps University, Marburg, Germany Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio-Emilia IRCCS (G.P.), Institute of Neurological Sciences of Bologna Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona Department of Medical Sciences and Public Health (M.F., M.P.), Sleep Disorder Research Center, University of Cagliari, Italy Paracelsus-Elena-Klinik (B.M., C.T., F.S.-D.), Kassel Department of Neurosurgery (B.M., C.T.), University Medical Centre Göttingen, Germany Sleep and Neurology Unit (V.C.D.C.), Beau Soleil Clinic EuroMov Digital Health in Motion (V.C.D.C.), University of Montpellier IMT Mines Ales University Lille North of France (C.C.M.), Department of Clinical Neurophysiology and Sleep Center, CHU Lille Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Müenster, Germany Department of Neurological Sciences (L.F.-S.), Università Vita-Salute San Raffaele, Milan, Italy Laboratory for Sleep Disorders (F.D., M.V.) and Department of Neurology (F.D., M.V.), St. Dimpna Regional Hospital, Geel Department of Neurology (F.D.), University Hospital Antwerp, Edegem, Belgium Sleep Disorder Unit (B.A.), Carémeau Hospital, University Hospital of Nîmes, France and Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN

Neurology. 2021 ; 96 (10) : e1402-e1412. [pub] 20210104

ISSN 1526-632X
Medvik
Zdroj

OBJECTIVE: To examine the role of genes identified through genome-wide association studies (GWASs) of Parkinson disease (PD) in the risk of isolated REM sleep behavior disorder (iRBD). METHODS: We fully sequenced 25 genes previously identified in GWASs of PD in a total of 1,039 patients with iRBD and 1,852 controls. The role of rare heterozygous variants in these genes was examined with burden tests. The contribution of biallelic variants was further tested. To examine the potential effect of rare nonsynonymous BST1 variants on the protein structure, we performed in silico structural analysis. Finally, we examined the association of common variants using logistic regression adjusted for age and sex. RESULTS: We found an association between rare heterozygous nonsynonymous variants in BST1 and iRBD (p = 0.0003 at coverage >50× and 0.0004 at >30×), driven mainly by 3 nonsynonymous variants (p.V85M, p.I101V, and p.V272M) found in 22 (1.2%) controls vs 2 (0.2%) patients. All 3 variants seem to be loss-of-function variants with a potential effect on the protein structure and stability. Rare noncoding heterozygous variants in LAMP3 were also associated with iRBD (p = 0.0006 at >30×). We found no association between rare heterozygous variants in the rest of genes and iRBD. Several carriers of biallelic variants were identified, yet there was no overrepresentation in iRBD. CONCLUSION: Our results suggest that rare coding variants in BST1 and rare noncoding variants in LAMP3 are associated with iRBD. Additional studies are required to replicate these results and to examine whether loss of function of BST1 could be a therapeutic target.

MeSH
ADP-ribosylcyklasa genetika MeSH
CD antigeny genetika MeSH
celogenomová asociační studie MeSH
databáze genetické MeSH
genetická variace MeSH
GPI-vázané proteiny genetika MeSH
heterozygot MeSH
lidé středního věku MeSH
lidé MeSH
membránové glykoproteiny asociované s lyzozomy genetika MeSH
nádorové proteiny genetika MeSH
počítačová simulace MeSH
polysomnografie MeSH
porucha chování v REM spánku epidemiologie genetika MeSH
sekundární struktura proteinů MeSH
senioři MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

Článek

Prospective memory impairment in idiopathic REM sleep behavior disorder

The Clinical neuropsychologist. 2018 ; 32 (5) : 1019-1037. [pub] 20171026

Clin Neuropsychol
ISSN 1744-4144
Medvik
Zdroj

OBJECTIVE: The aim of the present study was to investigate if prospective memory (PM) is impaired in idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). RBD is a parasomnia characterized by dream enactment and by REM sleep without muscle atonia. iRBD is considered as the initial stage of neurodegeneration with pathological storage of alpha-synuclein. METHOD: Sixty iRBD patients with polysomnography-confirmed RBD without parkinsonism and dementia and 30 demographically matched normal controls (NC) were enrolled in the present study. Clinical assessment included Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), dopamine transporter single-photon emission computed tomography (DaT-SPECT) for imaging synapses of dopaminergic neurons in the striatum and a neuropsychological battery with embedded time-based and event-based PM measures. RESULTS: iRBD differed significantly from NC in event-based PM, a number of event-based failures to recall intention and total PM performance (all p < .001) but did not differ in time-based PM and recognition. PM did not contribute to impairment of instrumental activities of daily living in iRBD. Despite being preserved in iRBD in comparison to NC, time-based PM correlated significantly with dopaminergic neuronal loss measured by DaT-SPECT. CONCLUSIONS: We show evidence for a differential pattern of PM impairment in iRBD with severe impairment of event-based and concurrent preservation of time-based PM. We theorize that event-based PM impairment in iRBD is caused by severe impairment of retention and recognition mechanisms in episodic memory whereas time-based PM seems to be affected by reduced striatal dopaminergic synapses.

MeSH
činnosti denního života psychologie MeSH
epizodická paměť * MeSH
jednofotonová emisní výpočetní tomografie metody MeSH
lidé středního věku MeSH
lidé MeSH
neuropsychologické testy MeSH
polysomnografie metody MeSH
porucha chování v REM spánku diagnostické zobrazování epidemiologie psychologie MeSH
poruchy paměti diagnostické zobrazování epidemiologie psychologie MeSH
senioři MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

Článek

Ohrožuje vaše pacienty s poruchami spánku Parkinson?

Zdravotnické noviny (Ambit Media). 2015 ; 64 (1-2) : 2.

ZN zdravotnické noviny
ISSN 0044-1996
Medvik
Zdroj

MeSH
časná diagnóza MeSH
lidé MeSH
Parkinsonova nemoc epidemiologie MeSH
porucha chování v REM spánku * diagnóza epidemiologie MeSH
poruchy spánku a bdění * diagnóza epidemiologie MeSH
průzkumy a dotazníky MeSH
Check Tag
lidé MeSH
Publikační typ
novinové články MeSH

Kapitola

Porucha chování v REM spánku

Šonka, Karel, 1957-
Autor Autorita ORCID Neurologická klinika a Centrum klinických neurověd 1. LF UK a VFN v Praze

Neurodegenerativní onemocnění. 2014 ; () : 40-44.

ISBN 978-80-204-3300-8
Medvik
Zdroj

Článek

Comorbidity and medication in REM sleep behavior disorder: a multicenter case-control study

Neurology. 2014 ; 82 (12) : 1076-9.

ISSN 1526-632X
Medvik
Zdroj

OBJECTIVE: This controlled study investigated associations between comorbidity and medication in patients with polysomnographically confirmed idiopathic REM sleep behavior disorder (iRBD), using a large multicenter clinic-based cohort. METHODS: Data of a self-administered questionnaire on comorbidity and medication use of 318 patients with iRBD and 318 matched controls were analyzed. Comparisons between cases and controls were made using logistic regression analysis. RESULTS: Patients with iRBD were more likely to report depression (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.3-2.9) and concomitant antidepressant use (OR 2.2, 95% CI 1.4-3.6). Subanalysis of antidepressant agents revealed that the increased use of antidepressants in iRBD was due to selective serotoninergic reuptake inhibitors (OR 3.6, 95% CI 1.8-7.0) and not due to other antidepressant classes. Patients with iRBD reported more lifetime antidepressant use than comorbid depression (antidepressant use: OR 1.9, 95% CI 1.1-3.3; depression: OR 1.6, 95% CI 1.0-2.5). Patients with iRBD reported more ischemic heart disease (OR 1.9, 95% CI 1.1-3.1). This association did not change substantially when adjusting for cardiovascular risk factors (OR 2.3, 95% CI 1.3-3.9). The use of inhaled glucocorticoids was higher in patients with iRBD compared to controls (OR 5.3, 95% CI 1.8-15.8), likely reflecting the higher smoking rate in iRBD (smoking: OR 15.3, 95% CI 2.0-118.8; nonsmoking: OR 2.4, 95% CI 0.4-13.2) and consequent pulmonary disease. CONCLUSIONS: This large study confirms the association between comorbid depression and antidepressant use in iRBD. In addition, there was an unexpected association of iRBD with ischemic heart disease that was not explained by cardiovascular risk factors.

Článek

Narcolepsy: clinical differences and association with other sleep disorders in different age groups

Journal of neurology. 2013 ; 260 (3) : 767-775.

J Neurol
ISSN 1432-1459
Medvik
Zdroj

Narcolepsy-cataplexy (N-C) is a focal neurodegenerative disease with a genetic predisposition and autoimmune etiology; the pathogenesis of narcolepsy without cataplexy (Nw/oC) is less clear. One hundred and forty eight patients underwent clinical face-to face interviews, polysomnography, multiple sleep latency testing and HLA-DQB1*0602 typing. The cohort was divided into four age groups: children and adolescents under 19 years (N = 31), adults aged 20-39 years (N = 51), 40-59 years (N = 28) and over 60 years (N = 38). N-C was found in 93 adults (79.5 %) compared with 16 pediatric patients (51.6 %) (p < 0.01), suggesting that at least some of the children were candidates for developing cataplexy in the future. Statistical evaluation showed an increasing age-related proportion of associated sleep disorders-obstructive sleep apnea, periodic leg movements and restless leg syndrome (p < 0.001). Nw/oC patients showed sleep comorbidities less frequently than N-C group. A close connection with N-C was found particularly in REM behavior disorder (RBD) (p < 0.05). RBD affected a third of the patients in the youngest as well as in the oldest groups. However, association with other sleep disorders had no significant effect on nocturnal sleep (with the exception of obstructive sleep apnea), and the sleep comorbidities under study had no noticeable effect on daytime sleepiness.

MeSH
dítě MeSH
dospělí MeSH
kohortové studie MeSH
lidé středního věku MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
narkolepsie diagnóza epidemiologie patofyziologie MeSH
polysomnografie metody MeSH
porucha chování v REM spánku diagnóza epidemiologie patofyziologie MeSH
poruchy spánku a bdění diagnóza epidemiologie patofyziologie MeSH
průřezové studie MeSH
senioři nad 80 let MeSH
senioři MeSH
stadia spánku fyziologie MeSH
syndrom neklidných nohou diagnóza epidemiologie patofyziologie MeSH
věkové faktory MeSH
Check Tag
dítě MeSH
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
senioři nad 80 let MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
srovnávací studie MeSH

Článek

Sleepiness in patients with obstructive sleep apnoea - daytime course and impact of nocturnal respiratory events

Neuro-endocrinology letters. 2012 ; 33 (7) : 684-8.

Neuro-endocrinol. lett.
ISSN 0172-780X
Medvik
Zdroj

BACKGROUND: Obstructive sleep apnoea (OSA) is a condition leading to excessive daytime sleepiness. The aim of the study was a) to study course of daytime sleepiness in patients with OSA and b) to find the most important nocturnal polysomnography parameters influencing daytime sleepiness in OSA. METHODS: The cohort consisted of forty-five patients (6 women, 39 men) diagnosed with OSA. All patients underwent polysomnography, Multiple Sleep Latency Test (MSLT) and rated subjectively their daytime tendency to sleep with the Epworth Sleepiness Scale. RESULTS: Sleep latency was significantly longer at 15:00 and at 17:00 hours compared to previous tests. A significant negative correlation was found between the mean of the MSLT sleep latency and a number of awakenings, the apnoea/hypopnoea index and oxygen desaturation index values. CONCLUSIONS: The study showed the sleep latency prolongation at 15:00 and 17:00 hours respectively and confirmed connection of excessive daytime sleepiness to fragmentation of nocturnal sleep and OSA severity.

MeSH
cirkadiánní rytmus fyziologie MeSH
dospělí MeSH
kardiovaskulární nemoci epidemiologie MeSH
kohortové studie MeSH
komorbidita MeSH
lidé středního věku MeSH
lidé MeSH
mladý dospělý MeSH
obstrukční spánková apnoe diagnóza epidemiologie patofyziologie MeSH
polysomnografie MeSH
porucha chování v REM spánku epidemiologie patofyziologie MeSH
poruchy nadměrné spavosti epidemiologie patofyziologie MeSH
senioři MeSH
spánek fyziologie MeSH
stadia spánku fyziologie MeSH
syndrom neklidných nohou epidemiologie patofyziologie MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

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