BACKGROUND AND OBJECTIVES: Trigeminal neuralgia affects approximately 2% of patients with multiple sclerosis (MS) and often shows higher rates of pain recurrence after treatment. Previous studies on the effectiveness of stereotactic radiosurgery (SRS) for trigeminal neuralgia did not consider the different MS subtypes, including remitting relapsing (RRMS), primary progressive (PPMS), and secondary progressive (SPMS). Our objective was to investigate how MS subtypes are related to pain control (PC) rates after SRS. METHODS: We conducted a retrospective multicenter analysis of prospectively collected databases. Pain status was assessed using the Barrow National Institute Pain Intensity Scales. Time to recurrence was estimated through the Kaplan-Meier method and compared groups using log-rank tests. Logistic regression was used to calculate the odds ratio (OR). RESULTS: Two hundred and fifty-eight patients, 135 (52.4%) RRMS, 30 (11.6%) PPMS, and 93 (36%) SPMS, were included from 14 institutions. In total, 84.6% of patients achieved initial pain relief, with a median time of 1 month; 78.7% had some degree of pain recurrence with a median time of 10.2 months for RRMS, 8 months for PPMS, 8.1 months for SPMS ( P = .424). Achieving Barrow National Institute-I after SRS was a predictor for longer periods without recurrence ( P = .028). Analyzing PC at the last available follow-up and comparing with RRMS, PPMS was less likely to have PC (OR = 0.389; 95% CI 0.153-0.986; P = .047) and SPMS was more likely (OR = 2.0; 95% CI 0.967-4.136; P = .062). A subgroup of 149 patients did not have other procedures apart from SRS. The median times to recurrence in this group were 11.1, 9.8, and 19.6 months for RRMS, PPMS, and SPMS, respectively (log-rank, P = .045). CONCLUSION: This study is the first to investigate the relationship between MS subtypes and PC after SRS, and our results provide preliminary evidence that subtypes may influence pain outcomes, with PPMS posing the greatest challenge to pain management.
- MeSH
- bolest etiologie chirurgie MeSH
- lidé MeSH
- lokální recidiva nádoru chirurgie MeSH
- management bolesti metody MeSH
- neuralgie trigeminu * radioterapie chirurgie MeSH
- radiochirurgie * metody MeSH
- retrospektivní studie MeSH
- roztroušená skleróza * chirurgie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND: Percutaneous rhizotomy of the Gasserian ganglion is a well-established intervention for patients suffering from refractory trigeminal pain, not amenable to pharmacological management or microvascular decompression. Traditionally conducted under fluoroscopic guidance using Hartel's technique, this study investigates a modified approach employing low-dose CT guidance to achieve maximal procedural precision and safety with the emphasis on minimizing radiation exposure. METHODS: A retrospective analysis of patients undergoing percutaneous rhizotomy of the Gasserian ganglion at our institution was undertaken. Procedures were divided into fluoroscopy and CT-guided foramen ovale (FO) cannulation cohorts. Radiation doses were assessed, excluding cases with incomplete data. The study included 32 procedures in the fluoroscopy group and 30 in the CT group. RESULTS: In the CT-guided group, the median effective dose was 0.21 mSv. The median number of CT scans per procedure was 4.5, and the median procedure time was 15 min. Successful FO cannulation was achieved in all 30 procedures (100%). In the fluoroscopy group, the median effective dose was 0.022 mSv, and the median procedure time was 15 min. Cannulation of FO was successful in 31 of 32 procedures (96.9%). The only complications in the CT-guided group were three minor cheek hematomas. Immediate pain relief in the CT-guided group was reported in 25 of 30 procedures (83.3%), 22 of 30 (73.3%) provided relief at one month, and 10 of 18 (55.6%) procedures resulting in pain relief at one month continued to provide relief after two years. CONCLUSION: Low-dose CT-guided percutaneous rhizotomy conducted in the radiology suite carries negligible radiation exposure for patients and eliminates it for personnel. This method is fast, simple, precise, and carries a very low risk of complications.
- MeSH
- dávka záření MeSH
- dospělí MeSH
- fluoroskopie metody MeSH
- ganglion trigeminale chirurgie diagnostické zobrazování MeSH
- lidé středního věku MeSH
- lidé MeSH
- neuralgie trigeminu * chirurgie diagnostické zobrazování radioterapie MeSH
- počítačová rentgenová tomografie * metody MeSH
- radiační expozice * prevence a kontrola MeSH
- retrospektivní studie MeSH
- rizotomie * metody MeSH
- senioři MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND AND OBJECTIVES: Trigeminal Neuralgia (TN) is a debilitating facial pain disorder, often necessitating surgical interventions when medication proves insufficient. Stereotactic Radiosurgery (SRS) is an established therapeutic option. Limited studies explored the feasibility of a third SRS procedure. Our study investigates the safety and efficacy of a third SRS procedure for recurrent TN. METHODS: We performed a retrospective analysis across multiple centers using databases collected prospectively. Pain status was evaluated utilizing the BNI Pain Intensity Scales. The Kaplan-Meier method was employed to estimate the time to recurrence, with group comparisons conducted using log-rank tests. Associations were explored using Chi-square and logistic regression models. RESULTS: Ten institutions contributed with a total of 35 patients. A third SRS revealed sustained effectiveness with a pain control rate of 82.7%. The median time to recurrence was 35.5 months. New sensory dysfunction following the third procedure occurred in 22% of patients who had preserved sensory function after the second procedure. When considering those who developed sensory dysfunction after the second procedure, 40% of the entire cohort was affected. There were no significant differences in pain recurrence intervals among the three procedures. A meta-analysis, combining data from previous studies, showed that 89.6% of patients achieved some degree of pain control after a third SRS, with 27.4% experiencing new sensory dysfunction and a median time to recurrence of 31.6 months. CONCLUSION: Our study, the largest on the topic, affirms the sustained effectiveness of a third SRS for TN, providing comparable pain relief to initial procedures. Notably, an extended pain-free interval after the third SRS session was observed. Facial sensory dysfunction emerged as the primary side effect. Larger studies are warranted to explore correlations with demographics and treatment parameters for a comprehensive understanding of repeat SRS in managing recurrent TN.
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- neuralgie trigeminu * chirurgie MeSH
- radiochirurgie * metody škodlivé účinky MeSH
- recidiva * MeSH
- reoperace MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
OBJECTIVE: Recent studies have suggested that biologically effective dose (BED) is an important correlate of pain relief and sensory dysfunction after Gamma Knife radiosurgery (GKRS) for trigeminal neuralgia (TN). The goal of this study was to determine if BED is superior to prescription dose in predicting outcomes in TN patients undergoing GKRS as a first procedure. METHODS: This was a retrospective study of 871 patients with type 1 TN from 13 GKRS centers. Patient demographics, pain characteristics, treatment parameters, and outcomes were reviewed. BED was compared with prescription dose and other dosimetric factors for their predictive value. RESULTS: The median age of the patients was 68 years, and 60% were female. Nearly 70% of patients experienced pain in the V2 and/or V3 dermatomes, predominantly on the right side (60%). Most patients had modified BNI Pain Intensity Scale grade IV or V pain (89.2%) and were taking 1 or 2 pain medications (74.1%). The median prescription dose was 80 Gy (range 62.5-95 Gy). The proximal trigeminal nerve was targeted in 77.9% of cases, and the median follow-up was 21 months (range 6-156 months). Initial pain relief (modified BNI Pain Intensity Scale grades I-IIIa) was noted in 81.8% of evaluable patients at a median of 30 days. Of 709 patients who achieved initial pain relief, 42.3% experienced at least one pain recurrence after GKRS at a median of 44 months, with 49.0% of these patients undergoing a second procedure. New-onset facial numbness occurred in 25.3% of patients after a median of 8 months. Age ≥ 63 years was associated with a higher probability of both initial pain relief and maintaining pain relief. A distal target location was associated with a higher probability of initial and long-term pain relief, but also a higher incidence of sensory dysfunction. BED ≥ 2100 Gy2.47 was predictive of pain relief at 30 days and 1 year for the distal target, whereas physical dose ≥ 85 Gy was significant for the proximal target, but the restricted range of BED values in this subgroup could be a confounding factor. A maximum brainstem point dose ≥ 29.5 Gy was associated with a higher probability of bothersome facial numbness. CONCLUSIONS: BED and physical dose were both predictive of pain relief and could be used as treatment planning goals for distal and proximal targets, respectively, while considering maximum brainstem point dose < 29.5 Gy as a potential constraint for bothersome numbness.
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- měření bolesti MeSH
- následné studie MeSH
- neuralgie trigeminu * radioterapie chirurgie MeSH
- radiochirurgie * škodlivé účinky MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
Ablační procedury, které jsou součástí funkční neurochirurgie, prodělávají v posledních letech renesanci. Mezi tyto procedury se řadí i mediální talamotomie jako analgetický výkon u širokého spektra bolestivých stavů. Jednou z možných indikací k mediální talamotomii je refrakterní neural gie trigeminu. Management pacientů s refrakterní neuralgií trigeminu je svízelný a mediální talamotomie pomocí Leksellova gama nože těmto pacientům může pomoci. Následující článek má za cíl stručně a přehledně představit mediální talamotomii pomocí Leksellova gama nože jako bezpečnou a efektivní metodu v léčbě chronické bolesti a naše zkušenosti s touto metodou u pacientů s neuralgií trigeminu, u kterých farmako logická i chirurgická léčba selhala.
Ablative procedures, as an important part of functional neurosurgery, have experienced a renaissance in recent years. These procedures include medial thalamotomy as an analgesic procedure for a wide range of pain syndromes. Refractory trigeminal neuralgia is one of the indications for medial thalamotomy. Management of patients with refractory trigeminal neuralgia is challenging, and medial thalamotomy using the Leksell gamma knife may help these patients. This article aims to briefly and clearly present medial thalamotomy using the Leksell gamma knife as a safe and effective method in the treatment of chronic pain and our experience with this procedure in patients with trigeminal neuralgia in whom pharmacological and surgical treatment has failed.
- Klíčová slova
- radiochirurgická talamotomie,
- MeSH
- lidé MeSH
- neuralgie trigeminu * chirurgie radioterapie MeSH
- radiochirurgie metody MeSH
- thalamus chirurgie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- bolest chirurgie MeSH
- duševní poruchy chirurgie MeSH
- elektrická stimulace * metody MeSH
- epilepsie * chirurgie MeSH
- hluboká mozková stimulace * metody MeSH
- lidé MeSH
- management bolesti MeSH
- neuralgie trigeminu chirurgie MeSH
- Parkinsonova nemoc chirurgie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Trigeminal nerve schwannomas (TS) are uncommon intracranial tumors, frequently presenting with debilitating trigeminal and/or oculomotor nerve dysfunction. While surgical resection has been described, its morbidity and mortality rates are non-negligible. Stereotactic radiosurgery (SRS) has emerged with variable results as a valuable alternative. Here, we aimed at reviewing the medical literature on TS treated with SRS so as to investigate rates of tumor control and symptomatic improvement. We reviewed manuscripts published between January 1990 and December 2019 on PubMed. Tumor control and symptomatic improvement rates were evaluated with separate meta-analyses. This meta-analysis included 18 studies comprising a total of 564 patients. Among them, only one reported the outcomes of linear accelerators (Linac), while the others of GK. Tumor control rates after SRS were 92.3% (range 90.1-94.5; p < 0.001), and tumor decrease rates were 62.7% (range 54.3-71, p < 0.001). Tumor progression rates were 9.4% (range 6.8-11.9, p < 0.001). Clinical improvement rates of trigeminal neuralgia were 63.5% (52.9-74.1, p < 0.001) and of oculomotor nerves were 48.2% (range 36-60.5, p < 0.001). Clinical worsening rate was 10.7% (range 7.6-13.8, p < 0.001). Stereotactic radiosurgery for TS is associated with high tumor control rates and favorable clinical outcomes, especially for trigeminal neuralgia and oculomotor nerves. However, patients should be correctly advised about the risk of tumor progression and potential clinical worsening. Future clinical studies should focus on standard reporting of clinical outcomes.
- MeSH
- lidé MeSH
- nádory kraniálních nervů * MeSH
- následné studie MeSH
- neuralgie trigeminu * chirurgie MeSH
- neurilemom * chirurgie MeSH
- radiochirurgie * MeSH
- retrospektivní studie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- přehledy MeSH
- systematický přehled MeSH
INTRODUCTION: Trigeminal neuralgia (TN) secondary to tumors is encountered in up to 6% of patients with facial pain syndromes and is considered to be associated with tumors affecting the trigeminal nerve pathways. The most frequent are meningiomas and vestibular schwannomas (VS). Stereotactic radiosurgery (SRS) has emerged as a valuable treatment, with heterogeneity of clinical results. We sought to review the medical literature on TN treated with SRS for meningiomas and VS and investigate the rates of improvement of TN symptoms. METHODS: We reviewed articles published between January 1990 and December 2019 in PubMed. Pain relief after SRS, the maintenance of pain relief, and TN recurrence and complications were evaluated with separate meta-analyses, taking into account the data on individual patients. RESULTS: Pain relief after SRS was reported as Barrow Neurological Institute (BNI) pain intensity scores of BNI I in 50.5% (range 36-65.1%) of patients and BNI I-IIIb in 83.8% (range 77.8-89.8%). There was no significant difference in series discussing outcomes for tumor targeting versus tumor and nerve targeting. Recurrences were described in 34.7% (range 21.7-47.6; tumor targeting). Maintenance of BNI I was reported in 36.4% (range 20.1-52.7) and BNI I-IIIb in 41.2% (range 29.8-52.7; tumor targeting series). When both the nerve and the tumor were targeted, only 1 series reported 86.7% with BNI I-IIIb at last follow-up. Complications were encountered in 12.6% (range 6.3-18.8; tumor targeting series) of patients; however, they were much higher, as high as 26.7%, in the only study reporting them after targeting both the nerve and the tumor. The most common complication was facial numbness. CONCLUSION: SRS for TNB secondary to benign tumors, such as meningiomas and VS, is associated with favorable clinical course, but less favorable than in idiopathic TN. There was, however, heterogeneity among reports and targeting approaches. Although targeting both the nerve and the tumor seemed to achieve better long-term results, the rate of complications was much higher and the number of patients treated was limited. Future clinical studies should focus on the standard reporting of clinical outcomes and randomization of targeting methods.
- MeSH
- lidé MeSH
- management bolesti metody MeSH
- meningeální nádory komplikace diagnóza chirurgie MeSH
- meningeom komplikace diagnóza chirurgie MeSH
- neuralgie trigeminu diagnóza etiologie chirurgie MeSH
- radiochirurgie metody trendy MeSH
- retrospektivní studie MeSH
- vestibulární schwannom komplikace diagnóza chirurgie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- systematický přehled MeSH
Cíl: Možnost předoperační detekce v. emissaria mastoidea pomocí HRCT a standardního CT při plánování retrosigmoideální kraniotomie, jenž je využívaná k přístupům do oblasti angulus pontocerebellaris. Metodika: Bylo vyhodnoceno celkem 100 nativních CT (4,5 mm silné řezy) a 100 CT v tenkých řezech - HRCT (1 mm silné řezy). Snímky byly získány z informačního systému PACS Fakultní nemocnice v Olomouci (FNOL). Hodnotili a srovnávali jsme jednotlivé zastoupení vena emissaria mastoidea při zobrazení standardním CT a HRCT na pravé i levé straně a zajímala nás senzitivita vyšetření v závislosti na rozměru kostěného kanálu pro žílu, tedy foramen mastoideum. Výsledky: Při vyšetření nativním CT nebylo ani jedno emissarium zobrazeno v 71 případech na pravé a v 62 případech na levé straně. Jedno emissarium bylo zobrazeno ve 28 případech na pravé a v 36 případech na levé straně. Více než jedno pak bylo poměrně vzácné a tvořily jej významné spojky širší než 3,5 mm. HRCT poskytuje vyšší senzitivitu detekce drobných emissarií, která nebyla ve velké většině na standardním CT patrná, v tomto případě bylo možné detekovat i poměrně vzácně zastoupená foramina mastoidea v počtu 3 až 4. Zatímco při zobrazení emissarií širších než 3 mm není rozdíl statisticky významný, u emissarií se šířkou kanálu menší než 2 mm je již rozdíl statisticky významný. Závěr: Benefit HRCT při plánování retrosigmnoideální kraniotomie je nesporný a pomáhá eliminovat řadu potencionálních komplikací.
Objective: Pre-operative detection of mastoid emissary veins using HRCT and standard CT in retrosigmoid craniotomy planning, which is used to access the cerebel-lopontine angle area. Methods: A total of 100 native CT scans (4.5 mm thick slices) and 100 CT scans in thin slices - HRCT (1 mm thick slices) were evaluated. Images were obtained from the PACS Information System of the Faculty Hospital in Olomouc (FNOL). We evaluated and compared individual occurence of mastoid emissary vein in standard CT and HRCT scans on both sides, left and right, and we were interested in the sensitivity of the examination depending on the size of bone canal for the vein, i.e. mastoid foramen. Results: In the native CT scan, there was no emissary visible in 71 cases on the right and 62 cases on the left. One emissary was visible in 28 cases on the right and 36 cases on the left. More than one was a relatively rare case and it was formed by significant connections wider than 3.5 mm. HRCT provides a higher detection sensitivity for small emissaries, which were mostly invisible in a standard CT scan, in this case it was also possible to detect a relatively rare case of 3-4 mastoid foramina. While the difference is not statistically significant when the emissaries are larger than 3 mm, in emissaries with the width of channel less than 2 mm it already becomes statistically significant. Conclusion: Benefit of HRCT in retrosigmnoid craniotomy planning is indisputable and helps to eliminate many potential complications.
- MeSH
- foramen magnum anatomie a histologie krevní zásobení MeSH
- kraniotomie * metody MeSH
- lidé MeSH
- mostomozečkový úhel chirurgie patologie MeSH
- mozkové žíly anatomie a histologie diagnostické zobrazování MeSH
- neuralgie trigeminu etiologie farmakoterapie chirurgie MeSH
- počítačová rentgenová tomografie metody přístrojové vybavení MeSH
- předoperační vyšetření přístrojové vybavení MeSH
- týlní kost anatomie a histologie krevní zásobení MeSH
- vestibulární schwannom chirurgie MeSH
- Check Tag
- lidé MeSH
