AIMS: We sought to identify biochemical predictors that indicate susceptibility to in-stent restenosis (ISR) after coronary artery bare-metal stenting. METHODS: A total of 111 consecutive patients with post-percutaneous coronary intervention (PCI) in-stent restenosis of a target lesion within 12 months were matched for age, sex, vessel diameter, and diabetes with 111 controls without post-PCI ISR. Plasma or serum levels of biochemical markers were measured: matrix metalloproteinases (MMP) 2, 3, 9; myeloperoxidase (MPO); asymmetric dimethylarginine (ADMA); lipoprotein (a) (Lp[a]); apolipoproteins E and D (ApoE and D); and lecitin-cholesterol acyltransferase (LCAT). Multivariable logistic regression association tests were performed. RESULTS: Increased plasma MMP-3 (OR: 1.013; 95% CI: 1.004-1.023; P = 0.005), MMP-9 (OR: 1.014; 95% CI: 1.008-1.020; P < 0.0001) or MPO (OR: 1,003; 95% CI: 1.001-1.005; P = 0.002) was significantly associated with increased risk of ISR. Increased levels of ADMA (OR: 0.212; 95% CI: 0.054-0.827; P = 0.026), ApoE (OR: 0.924; 95% CI: 0.899-0.951; P < 0.0001), ApoD (OR: 0.919; 95% CI: 0.880-0.959; P = 0.0001), or LCAT (OR: 0.927; 95% CI: 0.902-0.952; P < 0.0001) was associated with risk reduction. No correlation was found between plasma MMP-2 or Lp (a) and ISR risk. CONCLUSIONS: Increased levels of MMP-3, MMP-9, and MPO represent predictors of ISR after bare-metal stent implantation. In contrast, increased ADMA, LCAT, and Apo E and D indicate a decreased in-stent restenosis occurrence.

• Klíčová slova
• apolipoproteins D, apolipoproteins E, asymmetric dimethylarginine, in-stent restenosis, lecitin-cholesterol acyltransferase, matrix metalloproteinases, myeloperoxidase,
• MeSH
• apolipoproteiny D metabolismus   MeSH
• apolipoproteiny E metabolismus   MeSH
• arginin analogy a deriváty   metabolismus   MeSH
• biologické markery metabolismus   MeSH
• koronární angioplastika MeSH
• koronární restenóza diagnóza   patofyziologie   MeSH
• lecitincholesterolacyltransferasa metabolismus   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lipoprotein (a) metabolismus   MeSH
• matrixová metaloproteinasa 3 metabolismus   MeSH
• matrixová metaloproteinasa 9 metabolismus   MeSH
• okluze cévního štěpu diagnóza   patofyziologie   MeSH
• peroxidasa metabolismus   MeSH
• průchodnost cév fyziologie   MeSH
• senioři MeSH
• stenty * MeSH
• studie případů a kontrol MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• apolipoproteiny D MeSH
• apolipoproteiny E MeSH
• arginin MeSH
• biologické markery MeSH
• lecitincholesterolacyltransferasa MeSH
• lipoprotein (a) MeSH
• matrixová metaloproteinasa 3 MeSH
• matrixová metaloproteinasa 9 MeSH
• N,N-dimethylarginine MeSH Prohlížeč
• peroxidasa MeSH