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Pracoviště
Department of Basic and Preclinical S... 1 Department of Diagnostics and Clinica... 1 Department of Obstetrics and Gynecolo... 1 Department of Toxicology Poznan Unive... 1 Department of Veterinary Surgery Inst... 1 Division of Anatomy Department of Hum... 1 Physiolgy Graduate Faculty North Caro... 1 Prestage Department of Poultry Scienc... 1
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- Autor
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Pracoviště
Department of Basic and Preclinical S... 1 Department of Diagnostics and Clinica... 1 Department of Obstetrics and Gynecolo... 1 Department of Toxicology Poznan Unive... 1 Department of Veterinary Surgery Inst... 1 Division of Anatomy Department of Hum... 1 Physiolgy Graduate Faculty North Caro... 1 Prestage Department of Poultry Scienc... 1
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- Data, Krzysztof
- Kulus, Magdalena
- Ziemak, Hanna
- Chwarzyński, Mikołaj
- Piotrowska-Kempisty, Hanna
- Bukowska, Dorota
- Antosik, Paweł
- Mozdziak, Paul
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Kempisty, Bartosz
Autor Kempisty, Bartosz Division of Anatomy, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland Physiolgy Graduate Faculty, North Carolina State University, Raleigh, NC 27695, USA Department of Obstetrics and Gynecology, University Hospital and Masaryk University, 601 77 Brno, Czech Republic
PubMed
37759515
PubMed Central
PMC10528602
DOI
10.3390/cells12182293
PII: cells12182293
Knihovny.cz E-zdroje
Healing of dense regular connective tissue, due to a high fiber-to-cell ratio and low metabolic activity and regeneration potential, frequently requires surgical implantation or reconstruction with high risk of reinjury. An alternative to synthetic implants is using bioscaffolds obtained through decellularization, a process where the aim is to extract cells from the tissue while preserving the tissue-specific native molecular structure of the ECM. Proteins, lipids, nucleic acids and other various extracellular molecules are largely involved in differentiation, proliferation, vascularization and collagen fibers deposit, making them the crucial processes in tissue regeneration. Because of the multiple possible forms of cell extraction, there is no standardized protocol in dense regular connective tissue (DRCT). Many modifications of the structure, shape and composition of the bioscaffold have also been described to improve the therapeutic result following the implantation of decellularized connective tissue. The available data provide a valuable source of crucial information. However, the wide spectrum of decellularization makes it important to understand the key aspects of bioscaffolds relative to their potential use in tissue regeneration.
- Klíčová slova
- bioscaffold, extracellular matrix, ligament, tendon,
- MeSH
- buněčná diferenciace MeSH
- implantace embrya MeSH
- lidé MeSH
- nukleové kyseliny * MeSH
- patologická angiogeneze MeSH
- regenerativní lékařství * MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Názvy látek
- nukleové kyseliny * MeSH
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