Amphiphilic gradient copolymers represent a promising alternative to extensively used block copolymers due to their facile one-step synthesis by statistical copolymerization of monomers of different reactivity. Herein, an in-depth analysis is provided of micelles based on amphiphilic gradient poly(2-oxazoline)s with different chain lengths to evaluate their potential for micellar drug delivery systems and compare them to the analogous diblock copolymer micelles. Size, morphology, and stability of self-assembled nanoparticles, loading of hydrophobic drug curcumin, as well as cytotoxicities of the prepared nanoformulations are examined using copoly(2-oxazoline)s with varying chain lengths and comonomer ratios. In addition to several interesting differences between the two copolymer architecture classes, such as more compact self-assembled structures with faster exchange dynamics for the gradient copolymers, it is concluded that gradient copolymers provide stable curcumin nanoformulations with comparable drug loadings to block copolymer systems and benefit from more straightforward copolymer synthesis. The study demonstrates the potential of amphiphilic gradient copolymers as a versatile platform for the synthesis of new polymer therapeutics.

• Klíčová slova
• gradient copolymers, nanomedicine, poly(2-oxazoline)s, self-assembly,
• MeSH
• hydrofobní a hydrofilní interakce MeSH
• kurkumin * chemie   MeSH
• micely * MeSH
• nosiče léků chemie   MeSH
• polymery chemie   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• kurkumin * MeSH
• micely * MeSH
• nosiče léků MeSH
• polymery MeSH

Novel polymer micelles, prepared by self-assembling thermoresponsive poly(N-isopropylacrylamide)-graft-poly[N-(2-hydroxypropyl)methacrylamide] copolymers with hydrolytically degradable N-glycosylamine groups between the polymer blocks are proposed for delivery of diagnostic and therapeutic radionuclides into solid tumors. The micelles are formed by fast heating of an aqueous solution of the copolymer to 37 degrees C. They have a hydrodynamic diameter of 128 nm (measured using dynamic light scattering) and slowly degrade during incubation in aqueous buffer at pH = 7.4. Labeling with both (131)I and (90)Y proceeds with high yields (>85%). The unlabeled polymers are not cytotoxic for any of the tested murine and human cell lines.

• MeSH
• akrylamidy chemie   metabolismus   MeSH
• akrylové pryskyřice MeSH
• biokompatibilní materiály chemie   metabolismus   MeSH
• hydrolýza MeSH
• lidé MeSH
• micely * MeSH
• molekulární struktura MeSH
• nosiče léků * chemická syntéza   chemie   metabolismus   MeSH
• polymery * chemická syntéza   chemie   metabolismus   MeSH
• radionuklidy chemie   metabolismus   MeSH
• systémy cílené aplikace léků MeSH
• teplota * MeSH
• testování materiálů MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• akrylamidy MeSH
• akrylové pryskyřice MeSH
• biokompatibilní materiály MeSH
• micely * MeSH
• N-(2-hydroxypropyl)methacrylamide MeSH Prohlížeč
• nosiče léků * MeSH
• poly-N-isopropylacrylamide MeSH Prohlížeč
• polymery * MeSH
• radionuklidy MeSH